AutismKB 2.0

Annotation Details for NSD1


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Basic Information Top
Gene Symbol:NSD1 ( ARA267,DKFZp666C163,FLJ10684,FLJ22263,FLJ44628,KMT3B,SOTOS,STO )
Gene Full Name: nuclear receptor binding SET domain protein 1
Band: 5q35.3
Quick LinksEntrez ID:64324; OMIM: 606681; Uniprot ID:NSD1_HUMAN; ENSEMBL ID: ENSG00000165671; HGNC ID: 14234
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005694IEA-chromosome-
GO ID Evidence Qualifier GO_term References
GO:0000979IDA-RNA polymerase II core promoter sequence-specific DNA binding20837538
GO:0003682ISS-chromatin binding-
GO:0003712IDA-transcription cofactor activity11509567
GO:0003714ISS-transcription corepressor activity-
GO:0008270IDA-zinc ion binding21196496
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0030331ISS-estrogen receptor binding-
GO:0042799ISS-histone methyltransferase activity (H4-K20 specific)-
GO:0042974ISS-retinoic acid receptor binding-
GO:0046965ISS-retinoid X receptor binding-
GO:0046966ISS-thyroid hormone receptor binding-
GO:0046975IDA-histone methyltransferase activity (H3-K36 specific)21196496
GO:0046975ISS-histone methyltransferase activity (H3-K36 specific)-
GO:0050681IDA-androgen receptor binding11509567
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0000414IMP-regulation of histone H3-K36 methylation20837538
GO:0006351IEA-transcription, DNA-templated-
GO:0010452IEA-histone H3-K36 methylation-
GO:0016571ISS-histone methylation-
GO:0033135IMP-regulation of peptidyl-serine phosphorylation20837538
GO:0034770IEA-histone H4-K20 methylation-
GO:0045893IDA-positive regulation of transcription, DNA-templated11509567
GO:1903025IMP-regulation of RNA polymerase II regulatory region sequence-specific DNA binding20837538
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NSD1AR10686211509567 Reconstituted Complex; Two-hybrid
NSD1AR12213511509567 Reconstituted Complex; Two-hybrid
NSD1RELA12213520080798 Affinity Capture-Western
NSD1RELA11190220080798 Affinity Capture-Western
ZNF496NSD112429115169884 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZNF496NSD112213515169884 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1276545
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080519-2'