AutismKB 2.0

Annotation Details for SH3BP2


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Basic Information Top
Gene Symbol:SH3BP2 ( 3BP2,CRBM,CRPM,FLJ42079,FLJ54978 )
Gene Full Name: SH3-domain binding protein 2
Band: 4p16.3
Quick LinksEntrez ID:6452; OMIM: 602104; Uniprot ID:3BP2_HUMAN; ENSEMBL ID: ENSG00000087266; HGNC ID: 10825
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
No data
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0005070TAS-SH3/SH2 adaptor activity9299232
GO:0005515IPI-protein binding11390470
GO:0017124IEA-SH3 domain binding-
GO ID Evidence Qualifier GO_term References
GO:0007165TAS-signal transduction9299232
GO:0009967IEA-positive regulation of signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SH3BP2CBL1073159846481 Reconstituted Complex
SH3BP2CBL1123509846481 Reconstituted Complex
SH3BP2FYN1088109846481 Two-hybrid
SH3BP2FYN1123509846481 Two-hybrid
SH3BP2GRB21091429846481 Reconstituted Complex
SH3BP2GRB21123509846481 Reconstituted Complex
SH3BP2PLCG11113519846481 11390470 Far Western; Reconstituted Complex
SH3BP2PLCG11123509846481 11390470 Far Western; Reconstituted Complex
LATSH3BP21179719846481 11390470 Affinity Capture-Western; Reconstituted Complex
LATSH3BP21123509846481 11390470 Affinity Capture-Western; Reconstituted Complex
ZAP70SH3BP21133679846481 Affinity Capture-Western; Reconstituted Complex
ZAP70SH3BP21123509846481 Affinity Capture-Western; Reconstituted Complex
SYKSH3BP21123509846481 Two-hybrid
SYKSH3BP21127179846481 Two-hybrid
VAV1SH3BP211325211390470 Affinity Capture-Western; Far Western
VAV1SH3BP211235011390470 Affinity Capture-Western; Far Western
Gene Symbol Interactant Interaction ID References Description
SH3BP2FGFR125964915117958 An unspecified isoform of FGFR1 interacts with SH3BP2. This interaction was modeled on a demonstrated interaction between FGFR1 from an unspecified species and human SH3BP2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346349
  • Data Attributes: HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018