AutismKB 2.0

Annotation Details for ITSN1


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Basic Information Top
Gene Symbol:ITSN1 ( ITSN,MGC134948,MGC134949,SH3D1A,SH3P17 )
Gene Full Name: intersectin 1 (SH3 domain protein)
Band: 21q22.11
Quick LinksEntrez ID:6453; OMIM: 602442; Uniprot ID:ITSN1_HUMAN; ENSEMBL ID: ENSG00000205726; HGNC ID: 6183
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane20946875
GO:0005905IDA-clathrin-coated pit20946875
GO:0030027IEA-lamellipodium-
GO:0030054IEA-cell junction-
GO:0030139IEA-endocytic vesicle-
GO:0043005IEA-neuron projection-
GO:0045202IEA-synapse-
GO ID Evidence Qualifier GO_term References
GO:0005085NAS-guanyl-nucleotide exchange factor activity9799604
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005509NAS-calcium ion binding9799604
GO:0005515IPI-protein binding10064583
GO:0019209IEA-kinase activator activity-
GO:0032947IDA-protein complex scaffold20946875
GO:0070064IPI-proline-rich region binding20946875
GO ID Evidence Qualifier GO_term References
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0016032IEA-viral process-
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0042327IEA-positive regulation of phosphorylation-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0048013TAS-ephrin receptor signaling pathway-
GO:0048488TAS-synaptic vesicle endocytosis9799604
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051897IEA-positive regulation of protein kinase B signaling-
GO:0061024TAS-membrane organization-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ITSN1CBL10731516914641 Far Western
ITSN1CBL11235116914641 Far Western
ITSN1CDC4210743311584276 12006984 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
ITSN1CDC4211235111584276 12006984 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
ITSN1EEF1A110823716169070 Two-hybrid
ITSN1EEF1A111235116169070 Two-hybrid
ITSN1EPHB210836212389031 Affinity Capture-Western
ITSN1EPHB211235112389031 Affinity Capture-Western
ITSN1KIF5A11235116169070 Two-hybrid
ITSN1KIF5A10999916169070 Two-hybrid
SNAP23ITSN111430310373452 Reconstituted Complex
SNAP23ITSN111235110373452 Reconstituted Complex
SNAP25ITSN111250010373452 Reconstituted Complex; Two-hybrid
SNAP25ITSN111235110373452 Reconstituted Complex; Two-hybrid
SOS1ITSN111253710716926 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SOS1ITSN111235110716926 20936779 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SCAMP1ITSN111489910777571 Reconstituted Complex; Two-hybrid
SCAMP1ITSN111235110777571 Reconstituted Complex; Two-hybrid
STON2ITSN112452611381094 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STON2ITSN111235111381094 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
WASLITSN111446611584276 Reconstituted Complex
WASLITSN111235111584276 Reconstituted Complex
DISC1ITSN111806112812986 Two-hybrid
DISC1ITSN111235112812986 Two-hybrid
TSG101ITSN111310215256501 Two-hybrid
TSG101ITSN111235115256501 Two-hybrid
SNX5ITSN111802216169070 Two-hybrid
SNX5ITSN111235116169070 Two-hybrid
MRPL20ITSN112037416169070 Two-hybrid
MRPL20ITSN111235116169070 Two-hybrid
SMARCC2ITSN111248516169070 Two-hybrid
SMARCC2ITSN111235116169070 Two-hybrid
UNC119ITSN111454816169070 Two-hybrid
UNC119ITSN111235116169070 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
ASAP2ITSN121791415719014 DDEF2 (AMAP2) interacts with an unspecified isoform of ITSN1 (Intersectin1).
ASAP1ITSN121791115719014 DDEF1 (AMAP1) interacts with an unspecified isoform of ITSN1 (Intersectin1).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1338069
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-226'