AutismKB 2.0

Annotation Details for SHB


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Basic Information Top
Gene Symbol:SHB ( RP11-3J10.8,bA3J10.2 )
Gene Full Name: Src homology 2 domain containing adaptor protein B
Band: 9p13.1
Quick LinksEntrez ID:6461; OMIM: 600314; Uniprot ID:SHB_HUMAN; ENSEMBL ID: ENSG00000107338; HGNC ID: 10838
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body-
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0001784IPI-phosphotyrosine residue binding20624904
GO:0001948IEA-glycoprotein binding-
GO:0005070IEA-SH3/SH2 adaptor activity-
GO:0005515IPI-protein binding17112510
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0006469IEA-negative regulation of protein kinase activity-
GO:0006915IEA-apoptotic process-
GO:0007165TAS-signal transduction8302579
GO:0009967IEA-positive regulation of signal transduction-
GO:0030154IEA-cell differentiation-
GO:0042100IEA-B cell proliferation-
GO:0045624IEA-positive regulation of T-helper cell differentiation-
GO:0045931IEA-positive regulation of mitotic cell cycle-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0050852IEA-T cell receptor signaling pathway-
GO:0071425IEA-hematopoietic stem cell proliferation-
GO:1900194IEA-negative regulation of oocyte maturation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SHBCRK11235810964504 Affinity Capture-Western
SHBCRK10778810964504 Affinity Capture-Western
SHBEPS81123587537362 Affinity Capture-Western; Reconstituted Complex
SHBEPS81083737537362 Affinity Capture-Western; Reconstituted Complex
SHBFGFR11123587537362 Affinity Capture-Western; Reconstituted Complex
SHBFGFR11085517537362 Affinity Capture-Western; Reconstituted Complex
SHBGRB21123589484780 Affinity Capture-Western
SHBGRB21091429484780 Affinity Capture-Western
SHBIL2RB11235812200137 Reconstituted Complex
SHBIL2RB10977512200137 Reconstituted Complex
SHBIL2RG11235812200137 Reconstituted Complex
SHBIL2RG10977612200137 Reconstituted Complex
SHBJAK111235812200137 Reconstituted Complex
SHBJAK110991912200137 Reconstituted Complex
SHBJAK311235812200137 Reconstituted Complex
SHBJAK310992112200137 Reconstituted Complex
SHBKDR11235815026417 Affinity Capture-Western
SHBKDR10999215026417 Affinity Capture-Western
SHBLCP211235812084069 Affinity Capture-Western; Reconstituted Complex
SHBLCP211012912084069 Affinity Capture-Western; Reconstituted Complex
SHBPIK3R11123587537362 Affinity Capture-Western; Reconstituted Complex
SHBPIK3R11113137537362 Affinity Capture-Western; Reconstituted Complex
SHBPLCG111235810488157 Affinity Capture-Western
SHBPLCG111135110488157 Affinity Capture-Western
SRCSHB1123587537362 Affinity Capture-Western; Reconstituted Complex
SRCSHB1125927537362 Affinity Capture-Western; Reconstituted Complex
LATSHB11235810488157 12084069 Affinity Capture-Western
LATSHB11797110488157 12084069 Affinity Capture-Western
VAV1SHB11235812084069 Affinity Capture-Western; Reconstituted Complex
VAV1SHB11325212084069 Affinity Capture-Western; Reconstituted Complex
ZAP70SHB11235812084069 Affinity Capture-Western; Reconstituted Complex
ZAP70SHB11336712084069 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98294
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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