AutismKB 2.0

Annotation Details for SIPA1


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Basic Information Top
Gene Symbol:SIPA1 ( MGC102688,MGC17037,SPA1 )
Gene Full Name: signal-induced proliferation-associated 1
Band: 11q13.1
Quick LinksEntrez ID:6494; OMIM: 602180; Uniprot ID:SIPA1_HUMAN; ENSEMBL ID: ENSG00000213445; HGNC ID: 10885
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus9183624
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0030133IEA-transport vesicle-
GO:0043234IEA-protein complex-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005096EXP-GTPase activator activity16076873
GO:0005096NAS-GTPase activator activity9346962
GO:0005515IPI-protein binding21988832
GO:0008022IEA-protein C-terminus binding-
GO ID Evidence Qualifier GO_term References
GO:0007010NAS-cytoskeleton organization12059963
GO:0007162NAS-negative regulation of cell adhesion10373454
GO:0007165TAS-signal transduction9346962
GO:0008283TAS-cell proliferation9346962
GO:0030308NAS-negative regulation of cell growth9183624
GO:0035556NAS-intracellular signal transduction9346962
GO:0042631IEA-cellular response to water deprivation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045786NAS-negative regulation of cell cycle7799964
GO:0051056IEA-regulation of small GTPase mediated signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
RFWD2SIPA112213611461903 Two-hybrid
RFWD2SIPA111238511461903 Two-hybrid
BRD4SIPA111703615456879 Affinity Capture-Western; Reconstituted Complex
BRD4SIPA111238515456879 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107576
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018