AutismKB 2.0

Annotation Details for SKP1


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Basic Information Top
Gene Symbol:SKP1 ( EMC19,MGC34403,OCP-II,OCP2,SKP1A,TCEB1L,p19A )
Gene Full Name: S-phase kinase-associated protein 1
Band: 5q31.1
Quick LinksEntrez ID:6500; OMIM: 601434; Uniprot ID:SKP1_HUMAN; ENSEMBL ID: ENSG00000113558; HGNC ID: 10899
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus18929646
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm18929646
GO:0005829TAS-cytosol-
GO:0019005IDA-SCF ubiquitin ligase complex11956208
GO:0031467IDA-Cul7-RING ubiquitin ligase complex18498745
GO:0031519IDAcolocalizes_withPcG protein complex16943429
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004842EXP-ubiquitin-protein transferase activity11158290
GO:0004842IDA-ubiquitin-protein transferase activity20347421
GO:0004842TAS-ubiquitin-protein transferase activity-
GO:0005515IPI-protein binding11099048
GO:0008013IDA-beta-catenin binding12820959
GO:0019904IPI-protein domain specific binding15996101
GO:0061630IDAcontributes_toubiquitin protein ligase activity12820959
GO:0097602IPI-cullin family protein binding18929646
GO ID Evidence Qualifier GO_term References
GO:0000086TAS-G2/M transition of mitotic cell cycle-
GO:0000209TAS-protein polyubiquitination-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0006879TAS-cellular iron ion homeostasis-
GO:0010265TAS-SCF complex assembly-
GO:0010972TAS-negative regulation of G2/M transition of mitotic cell cycle-
GO:0016055TAS-Wnt signaling pathway-
GO:0016567IDA-protein ubiquitination15103331
GO:0031146IDA-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process15103331
GO:0031146TAS-SCF-dependent proteasomal ubiquitin-dependent protein catabolic process-
GO:0035518IDA-histone H2A monoubiquitination16943429
GO:0038061TAS-NIK/NF-kappaB signaling-
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043161TAS-proteasome-mediated ubiquitin-dependent protein catabolic process-
GO:0043687TAS-post-translational protein modification-
GO:0050852TAS-T cell receptor signaling pathway-
GO:0051403TAS-stress-activated MAPK cascade-
GO:0051437TAS-positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition-
GO:0051457IPI-maintenance of protein location in nucleus21378169
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SKP1CDK911239111689688 Affinity Capture-Western; Reconstituted Complex
SKP1CDK910745911689688 Affinity Capture-Western; Reconstituted Complex
SKP1CTNNB111239111389839 Affinity Capture-Western
SKP1CTNNB110788011389839 Affinity Capture-Western
SKP1ETV611239118426905 Affinity Capture-Western
SKP1ETV610842118426905 Affinity Capture-Western
SKP1RBL211186912717421 Affinity Capture-Western
SKP1RBL211239112717421 Affinity Capture-Western
CUL1SKP11140329430629 10230407 11961546 12609982 12628165 15452136 15966899 16357137 16759355 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
CUL1SKP11123919430629 10230407 11961546 12609982 12628165 15452136 15966899 16357137 16759355 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BTRCSKP11144579660940 10531035 10644755 10918611 11483504 12609982 12820959 15070733 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BTRCSKP11123919660940 10531035 10644755 10918611 11483504 12609982 12820959 15070733 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SKP2SKP11123939827542 10531035 10559858 10918611 11099048 12609982 15070733 15342634 15452136 15469821 16880511 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SKP2SKP11123919827542 10531035 10559858 10918611 11099048 12609982 15070733 15342634 15452136 15469821 16880511 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
FBXO4SKP111765610531035 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO4SKP111239110531035 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO7SKP111732610531035 15145941 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO7SKP111239110531035 15145941 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXW2SKP111239110531035 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXW2SKP111760310531035 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXL3SKP111761510531035 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXL3SKP111239110531035 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO5SKP111765510531035 Reconstituted Complex; Two-hybrid
FBXO5SKP111239110531035 Reconstituted Complex; Two-hybrid
FBXO44SKP112503810531035 Reconstituted Complex; Two-hybrid
FBXO44SKP111239110531035 Reconstituted Complex; Two-hybrid
FBXL5SKP111762510531037 Reconstituted Complex
FBXL5SKP111239110531037 Reconstituted Complex
FBXL4SKP111762610531037 Reconstituted Complex
FBXL4SKP111239110531037 Reconstituted Complex
FBXW11SKP111688710644755 15070733 19615732 Affinity Capture-MS; Affinity Capture-Western
FBXW11SKP111239110644755 15070733 19615732 Affinity Capture-MS; Affinity Capture-Western
TBL1XSKP111239111389839 Affinity Capture-Western
TBL1XSKP111277011389839 Affinity Capture-Western
CACYBPSKP111800111389839 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CACYBPSKP111239111389839 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXW7SKP112058111585921 12628165 17434132 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
FBXW7SKP111239111585921 12628165 17434132 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
FBXO32SKP112539511717410 Reconstituted Complex
FBXO32SKP111239111717410 Reconstituted Complex
SNRNP70SKP111250911850407 Affinity Capture-Western
SNRNP70SKP111239111850407 Affinity Capture-Western
FBXO18SKP112433311956208 15118074 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXO18SKP111239111956208 15118074 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FBXW8SKP111764512481031 Affinity Capture-Western
FBXW8SKP111239112481031 Affinity Capture-Western
CUL7SKP111239112481031 Affinity Capture-Western
CUL7SKP111515912481031 Affinity Capture-Western
RBX1SKP111530112628165 15452136 16357137 Affinity Capture-Western; Reconstituted Complex
RBX1SKP111239112628165 15452136 16357137 Affinity Capture-Western; Reconstituted Complex
CDCA3SKP111239112679038 Affinity Capture-Western; Reconstituted Complex
CDCA3SKP112365712679038 Affinity Capture-Western; Reconstituted Complex
SUGT1SKP111239112746458 Reconstituted Complex
SUGT1SKP111611512746458 Reconstituted Complex
TBK1SKP111239114743216 Affinity Capture-MS
TBK1SKP111887814743216 Affinity Capture-MS
GCM1SKP111409315640526 Affinity Capture-Western
GCM1SKP111239115640526 Affinity Capture-Western
ZC3HC1SKP111959216009132 17389604 Affinity Capture-Western; Reconstituted Complex
ZC3HC1SKP111239116009132 17389604 Affinity Capture-Western; Reconstituted Complex
FBXO34SKP112035916169070 Two-hybrid
FBXO34SKP111239116169070 Two-hybrid
FBXO31SKP112289016357137 Affinity Capture-Western
FBXO31SKP111239116357137 Affinity Capture-Western
TRIM21SKP111239116880511 Affinity Capture-Western; Co-fractionation
TRIM21SKP111261516880511 Affinity Capture-Western; Co-fractionation
BCORSKP112022816943429 Affinity Capture-MS
BCORSKP111239116943429 Affinity Capture-MS
PCGF1SKP112424316943429 Affinity Capture-MS
PCGF1SKP111239116943429 Affinity Capture-MS
KDM2BSKP112419716943429 Reconstituted Complex
KDM2BSKP111239116943429 Reconstituted Complex
FBXO11SKP111239117098746 Affinity Capture-Western
FBXO11SKP112317317098746 Affinity Capture-Western
FBXO2SKP111762317389369 Co-crystal Structure
FBXO2SKP111239117389369 Co-crystal Structure
C13orf34SKP112295418378770 Affinity Capture-Western
C13orf34SKP111239118378770 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
FBXL2SKP118370610531037 Skp1 interacts with Fbl2.
FBXL4SKP118370710531037 Skp1 interacts with Fbl4.
FBXL5SKP118370810531037 Skp1 interacts with Fbl5.
FBXO3SKP118370310531037 Skp1 interacts with Fbx3.
FBXW2SKP118370410531037 Skp1 interacts with Fbw2.
FBXW2SKP121608615070733 An unspecified isoform of SKP1 interacts with FBW2.
FBXO7SKP118371010531037 Skp1 interacts with Fbx7.
FBXL7SKP121544715070733 An unspecified isoform of SKP1 interacts with FBL7.
KDM2ASKP121609015070733 An unspecified isoform of SKP1 interacts with FBL11.
ZC3HC1SKP131593316009132 NIPA interacts with an unspecified isoform Skp1.
FBXW8SKP121608715070733 An unspecified isoform of SKP1 interacts with an unspecified isoform of FBW6.
FBXO41SKP121608915070733 An unspecified isoform of SKP1 interacts with KIAA1940.
FBXW4P1SKP121608515070733 An unspecified isoform of SKP1 interacts with FBW3.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103575
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1707'