AutismKB 2.0

Annotation Details for SLC1A1


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Basic Information Top
Gene Symbol:SLC1A1 ( EAAC1,EAAT3 )
Gene Full Name: solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Band: 9p24.2
Quick LinksEntrez ID:6505; OMIM: 133550; Uniprot ID:EAA3_HUMAN; ENSEMBL ID: ENSG00000106688; HGNC ID: 10939
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane21123949
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane7521911
GO:0016020TAS-membrane7521911
GO:0016324IDA-apical plasma membrane21123949
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0005313IDA-L-glutamate transmembrane transporter activity7521911
GO:0005314TAS-high-affinity glutamate transmembrane transporter activity-
GO:0005515IPI-protein binding25416956
GO:0015171TAS-amino acid transmembrane transporter activity-
GO:0015501IEA-glutamate:sodium symporter activity-
GO:0016595IEA-glutamate binding-
GO:0033229IDA-cysteine transmembrane transporter activity21123949
GO ID Evidence Qualifier GO_term References
GO:0006811TAS-ion transport-
GO:0007268TAS-chemical synaptic transmission7521911
GO:0010460IEA-positive regulation of heart rate-
GO:0014047TAS-glutamate secretion-
GO:0042883IDA-cysteine transport21123949
GO:0051260IEA-protein homooligomerization-
GO:0051938IDA-L-glutamate import7521911
GO:0070779IDA-D-aspartate import7521911
GO:0089711IDA-L-glutamate transmembrane transport21123949
GO:1903712IEA-cysteine transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SLC1A1EWSR110843116189514 Two-hybrid
SLC1A1EWSR111239616189514 Two-hybrid
SLC1A1PRKCA11239612843260 Affinity Capture-Western
SLC1A1PRKCA11156412843260 Affinity Capture-Western
ARL6IP5SLC1A111239611242046 Affinity Capture-Western; Reconstituted Complex
ARL6IP5SLC1A111580111242046 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
SLC1A1rs2094806, rs2228622, rs2381122, rs301430, rs3087879, rs3780412, rs3780414, rs928209 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:105083
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040718-414'