AutismKB 2.0

Annotation Details for WNK3


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Basic Information Top
Gene Symbol:WNK3 ( FLJ30437,FLJ42662,KIAA1566,PRKWNK3 )
Gene Full Name: WNK lysine deficient protein kinase 3
Band: Xp11.22
Quick LinksEntrez ID:65267; OMIM: 300358; Uniprot ID:WNK3_HUMAN; ENSEMBL ID: ENSG00000196632; HGNC ID: 14543
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm16501604
GO:0005829IBA-cytosol-
GO:0005912ISS-adherens junction-
GO:0005923ISS-bicellular tight junction-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity16275913
GO:0004674IDA-protein serine/threonine kinase activity17975670
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0005515IPI-protein binding16501604
GO:0005524ISS-ATP binding-
GO:0019869IDA-chloride channel inhibitor activity17673510
GO ID Evidence Qualifier GO_term References
GO:0006468ISS-protein phosphorylation-
GO:0010765IDA-positive regulation of sodium ion transport16275913
GO:0010800IDA-positive regulation of peptidyl-threonine phosphorylation16275913
GO:0032414IDA-positive regulation of ion transmembrane transporter activity16275913
GO:0035556IBA-intracellular signal transduction-
GO:0035556ISS-intracellular signal transduction-
GO:0043066IMP-negative regulation of apoptotic process16501604
GO:0046777IDA-protein autophosphorylation16275913
GO:0051928IMP-positive regulation of calcium ion transport18768590
GO:0072661IMP-protein targeting to plasma membrane18768590
GO:0090004IDA-positive regulation of establishment of protein localization to plasma membrane16275913
GO:0090188IEA-negative regulation of pancreatic juice secretion-
GO:0090279IMP-regulation of calcium ion import18768590
GO:2000021IMP-regulation of ion homeostasis21613606
GO:2000651IDA-positive regulation of sodium ion transmembrane transporter activity16275913
GO:2000651IMP-positive regulation of sodium ion transmembrane transporter activity21613606
GO:2000682IDA-positive regulation of rubidium ion transport16275913
GO:2000688IDA-positive regulation of rubidium ion transmembrane transporter activity16275913
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2652875
  • Data Attributes: MGI curated and HomoloGene calculated
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018