AutismKB 2.0

Annotation Details for WNK2


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Basic Information Top
Gene Symbol:WNK2 ( KIAA1760,NY-CO-43,P/OKcl.13,PRKWNK2,SDCCAG43 )
Gene Full Name: WNK lysine deficient protein kinase 2
Band: 9q22.31
Quick LinksEntrez ID:65268; OMIM: 606249; Uniprot ID:WNK2_HUMAN; ENSEMBL ID: ENSG00000165238; HGNC ID: 14542
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm17667937
GO:0005829IBA-cytosol-
GO:0005829IDA-cytosol-
GO:0005886IEA-plasma membrane-
GO ID Evidence Qualifier GO_term References
GO:0004674IBA-protein serine/threonine kinase activity-
GO:0004674ISS-protein serine/threonine kinase activity-
GO:0005524ISS-ATP binding-
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation21733846
GO:0008285IMP-negative regulation of cell proliferation17667937
GO:0035556ISS-intracellular signal transduction-
GO:0046777IDA-protein autophosphorylation17667937
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade17667937
GO:2000021IMP-regulation of ion homeostasis21733846
GO:2000651IMP-positive regulation of sodium ion transmembrane transporter activity21733846
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
WNK2YWHAZ11336620936779 Two-hybrid
WNK2YWHAZ12242320936779 Two-hybrid
WNK2WNK112240320936779 Two-hybrid
WNK2WNK112242320936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1922857
  • Data Attributes: HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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