Gene Symbol:	SLC6A4 ( 5-HTT,5-HTTLPR,5HTT,HTT,OCD1,SERT,hSERT )
Gene Full Name:	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Band:	17q11.2
Quick Links	Entrez ID:6532; OMIM: 182138; Uniprot ID:SC6A4_HUMAN; ENSEMBL ID: ENSG00000108576; HGNC ID: 11050
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005829	IDA	-	cytosol	19270731
GO:0005886	IDA	-	plasma membrane	16870614
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	IBA	-	integral component of plasma membrane	-
GO:0005887	IC	-	integral component of plasma membrane	19270731
GO:0010008	IEA	-	endosome membrane	-
GO:0012505	IDA	-	endomembrane system	17506858
GO:0043005	IBA	-	neuron projection	-
GO:0045121	IDA	-	membrane raft	16870614
GO:0098793	IEA	-	presynapse	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0005330	IBA	-	dopamine:sodium symporter activity	-
GO:0005335	IDA	-	serotonin:sodium symporter activity	8987735
GO:0005335	IMP	-	serotonin:sodium symporter activity	19270731
GO:0005335	TAS	-	serotonin:sodium symporter activity	-
GO:0005515	IPI	-	protein binding	11343649
GO:0008504	IDA	-	monoamine transmembrane transporter activity	16024787
GO:0015222	IDA	-	serotonin transmembrane transporter activity	8987735
GO:0015222	IMP	-	serotonin transmembrane transporter activity	19270731
GO:0017022	IEA	-	myosin binding	-
GO:0017075	IEA	-	syntaxin-1 binding	-
GO:0017137	IPI	-	Rab GTPase binding	18227069
GO:0019811	IEA	-	cocaine binding	-
GO:0042803	IEA	-	protein homodimerization activity	-
GO:0046872	IEA	-	metal ion binding	-
GO:0050998	IEA	-	nitric-oxide synthase binding	-
GO:0051015	ISS	-	actin filament binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001666	IEA	-	response to hypoxia	-
GO:0006837	IDA	-	serotonin transport	19270731
GO:0007584	IEA	-	response to nutrient	-
GO:0007613	IEA	-	memory	-
GO:0007623	IEA	-	circadian rhythm	-
GO:0009636	IDA	-	response to toxic substance	17575980
GO:0010628	IEA	-	positive regulation of gene expression	-
GO:0014064	IEA	-	positive regulation of serotonin secretion	-
GO:0015844	IDA	-	monoamine transport	16024787
GO:0021794	IMP	-	thalamus development	18378990
GO:0021941	IEA	-	negative regulation of cerebellar granule cell precursor proliferation	-
GO:0032227	IEA	-	negative regulation of synaptic transmission, dopaminergic	-
GO:0032355	IEA	-	response to estradiol	-
GO:0035176	ISS	-	social behavior	-
GO:0042136	TAS	-	neurotransmitter biosynthetic process	-
GO:0042310	IEA	-	vasoconstriction	-
GO:0042493	IEA	-	response to drug	-
GO:0042713	IEA	-	sperm ejaculation	-
GO:0045665	IEA	-	negative regulation of neuron differentiation	-
GO:0045787	IEA	-	positive regulation of cell cycle	-
GO:0046621	ISS	-	negative regulation of organ growth	-
GO:0048854	ISS	-	brain morphogenesis	-
GO:0051259	ISS	-	protein oligomerization	-
GO:0051260	IEA	-	protein homooligomerization	-
GO:0051583	IBA	-	dopamine uptake involved in synaptic transmission	-
GO:0051610	IDA	-	serotonin uptake	8987735
GO:0051610	IMP	-	serotonin uptake	7681602
GO:0071300	IEA	-	cellular response to retinoic acid	-
GO:0071321	IEA	-	cellular response to cGMP	-
GO:0072488	IEA	-	ammonium transmembrane transport	-

Gene Symbol	Interactant	Interaction ID	References	Description
SLC6A4	CALR	112423	10364189	Reconstituted Complex
SLC6A4	CALR	107262	10364189	Reconstituted Complex
SLC6A4	CANX	112423	10364189	Reconstituted Complex
SLC6A4	CANX	107271	10364189	Reconstituted Complex
STX1A	SLC6A4	112676	12175857	Affinity Capture-Western
STX1A	SLC6A4	112423	12175857	Affinity Capture-Western

AutismKB 2.0

Annotation Details for SLC6A4