AutismKB 2.0

Annotation Details for SLC8A1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SLC8A1 ( DKFZp779F0871,FLJ37694,FLJ43417,MGC119581,NCX1 )
Gene Full Name: solute carrier family 8 (sodium/calcium exchanger), member 1
Band: 2p22.1
Quick LinksEntrez ID:6546; OMIM: 182305; Uniprot ID:NAC1_HUMAN; ENSEMBL ID: ENSG00000183023; HGNC ID: 11068
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005739IEA-mitochondrion-
GO:0005874IEA-microtubule-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane19095005
GO:0005887IDA-integral component of plasma membrane1374913
GO:0014704ISS-intercalated disc-
GO:0014704TAS-intercalated disc17614935
GO:0030018ISS-Z disc-
GO:0030315ISS-T-tubule-
GO:0030315TAS-T-tubule17614935
GO:0042383ISS-sarcolemma-
GO:0043197IEA-dendritic spine-
GO:0043198IEA-dendritic shaft-
GO:0045211IEA-postsynaptic membrane-
GO ID Evidence Qualifier GO_term References
GO:0005432IDA-calcium:sodium antiporter activity1374913
GO:0005432IMP-calcium:sodium antiporter activity25589784
GO:0005432TAS-calcium:sodium antiporter activity-
GO:0005509ISS-calcium ion binding-
GO:0005515IPI-protein binding25589784
GO:0005516IEA-calmodulin binding-
GO:0008092IDA-cytoskeletal protein binding16292983
GO:0030506IPI-ankyrin binding17178715
GO:0030506ISS-ankyrin binding-
GO:0044325ISS-ion channel binding-
GO:0099580IEA-ion antiporter activity involved in regulation of postsynaptic membrane potential-
GO ID Evidence Qualifier GO_term References
GO:0002026IC-regulation of the force of heart contraction19481548
GO:0002026ISS-regulation of the force of heart contraction-
GO:0002027ISS-regulation of heart rate-
GO:0002028IEA-regulation of sodium ion transport-
GO:0006811TAS-ion transport-
GO:0006883IDA-cellular sodium ion homeostasis1374913
GO:0006936TAS-muscle contraction1374913
GO:0007584IEA-response to nutrient-
GO:0009749IEA-response to glucose-
GO:0010649TAS-regulation of cell communication by electrical coupling17614935
GO:0010763IEA-positive regulation of fibroblast migration-
GO:0010881ISS-regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion-
GO:0010881TAS-regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion23608603
GO:0010882TAS-regulation of cardiac muscle contraction by calcium ion signaling23224879
GO:0014829ISS-vascular smooth muscle contraction-
GO:0021537IEA-telencephalon development-
GO:0030501IMP-positive regulation of bone mineralization25589784
GO:0033198IEA-response to ATP-
GO:0035725IGI-sodium ion transmembrane transport25589784
GO:0035725IMP-sodium ion transmembrane transport25589784
GO:0035902IEA-response to immobilization stress-
GO:0035994IMP-response to muscle stretch15105296
GO:0042493IEA-response to drug-
GO:0042542IEA-response to hydrogen peroxide-
GO:0044557ISS-relaxation of smooth muscle-
GO:0051481ISS-negative regulation of cytosolic calcium ion concentration-
GO:0055013ISS-cardiac muscle cell development-
GO:0055074ISS-calcium ion homeostasis-
GO:0055119IC-relaxation of cardiac muscle19481548
GO:0055119TAS-relaxation of cardiac muscle23224879
GO:0060048TAS-cardiac muscle contraction23224879
GO:0060078IEA-regulation of postsynaptic membrane potential-
GO:0060401TAS-cytosolic calcium ion transport19095005
GO:0060402ISS-calcium ion transport into cytosol-
GO:0070509IDA-calcium ion import1374913
GO:0070588IGI-calcium ion transmembrane transport25589784
GO:0071313ISS-cellular response to caffeine-
GO:0071320IEA-cellular response to cAMP-
GO:0071436IEA-sodium ion export-
GO:0071456IEA-cellular response to hypoxia-
GO:0086012TAS-membrane depolarization during cardiac muscle cell action potential23608603
GO:0086064ISS-cell communication by electrical coupling involved in cardiac conduction-
GO:0097369IDA-sodium ion import1374913
GO:0098735IMP-positive regulation of the force of heart contraction15105296
GO:1903779TAS-regulation of cardiac conduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SLC8A1CAV311243611821059 Affinity Capture-Western
SLC8A1CAV310730711821059 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107956
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050809-1'