AutismKB 2.0

Annotation Details for SLC9A1


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Basic Information Top
Gene Symbol:SLC9A1 ( APNH,FLJ42224,NHE1 )
Gene Full Name: solute carrier family 9 (sodium/hydrogen exchanger), member 1
Band: 1p36.11
Quick LinksEntrez ID:6548; OMIM: 107310; Uniprot ID:SL9A1_HUMAN; ENSEMBL ID: ENSG00000090020; HGNC ID: 11071
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm21553168
GO:0005739IEA-mitochondrion-
GO:0005783ISS-endoplasmic reticulum-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane15035633
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane24840010
GO:0005925IDA-focal adhesion21423176
GO:0009986IEA-cell surface-
GO:0014704IEA-intercalated disc-
GO:0016021TAS-integral component of membrane8283968
GO:0016323IEA-basolateral plasma membrane-
GO:0016324IEA-apical plasma membrane-
GO:0030027TAS-lamellipodium17565280
GO:0030315IEA-T-tubule-
GO:0045121IDA-membrane raft22688515
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19199708
GO:0090533IDA-cation-transporting ATPase complex24840010
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding8901634
GO:0005516IEA-calmodulin binding-
GO:0005546TAS-phosphatidylinositol-4,5-bisphosphate binding17565280
GO:0015299TAS-solute:proton antiporter activity2536298
GO:0015385IDA-sodium:proton antiporter activity8901634
GO:0015385ISS-sodium:proton antiporter activity-
GO:0015385TAS-sodium:proton antiporter activity-
GO:0015386IBA-potassium:proton antiporter activity-
GO:0030346IDA-protein phosphatase 2B binding22688515
GO:0030346IPI-protein phosphatase 2B binding22688515
GO:0030674TAS-protein binding, bridging17565280
GO:0032947TAS-protein complex scaffold17565280
GO:0048306IDA-calcium-dependent protein binding15035633
GO:0086040TAS-sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential24840010
GO ID Evidence Qualifier GO_term References
GO:0006811TAS-ion transport-
GO:0006883IDA-cellular sodium ion homeostasis24840010
GO:0006885IDA-regulation of pH8901634
GO:0006885TAS-regulation of pH8283968
GO:0010447IDA-response to acidic pH8901634
GO:0010613IMP-positive regulation of cardiac muscle hypertrophy21359875
GO:0010882IMP-regulation of cardiac muscle contraction by calcium ion signaling15105296
GO:0016049IEA-cell growth-
GO:0016477TAS-cell migration17565280
GO:0030011TAS-maintenance of cell polarity17565280
GO:0030214TAS-hyaluronan catabolic process-
GO:0030307IEA-positive regulation of cell growth-
GO:0032869IEA-cellular response to insulin stimulus-
GO:0035794IEA-positive regulation of mitochondrial membrane permeability-
GO:0035994IMP-response to muscle stretch15105296
GO:0042493IEA-response to drug-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0045760IEA-positive regulation of action potential-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22688515
GO:0051259ISS-protein oligomerization-
GO:0051453IDA-regulation of intracellular pH15035633
GO:0051492TAS-regulation of stress fiber assembly17565280
GO:0051533IDA-positive regulation of NFAT protein import into nucleus22688515
GO:0051893TAS-regulation of focal adhesion assembly17565280
GO:0051930IEA-regulation of sensory perception of pain-
GO:0055007IEA-cardiac muscle cell differentiation-
GO:0070886IDA-positive regulation of calcineurin-NFAT signaling cascade22688515
GO:0070997IEA-neuron death-
GO:0071236IEA-cellular response to antibiotic-
GO:0071257IEA-cellular response to electrical stimulus-
GO:0071260TAS-cellular response to mechanical stimulus17565280
GO:0071436ISS-sodium ion export-
GO:0071456IEA-cellular response to hypoxia-
GO:0071468IDA-cellular response to acidic pH24840010
GO:0071468ISS-cellular response to acidic pH-
GO:0071805IBA-potassium ion transmembrane transport-
GO:0071872IMP-cellular response to epinephrine stimulus21359875
GO:0086003IEA-cardiac muscle cell contraction-
GO:0086036TAS-regulation of cardiac muscle cell membrane potential24840010
GO:0086092IMP-regulation of the force of heart contraction by cardiac conduction21359875
GO:0098719IDA-sodium ion import across plasma membrane24840010
GO:0098735IMP-positive regulation of the force of heart contraction15105296
GO:1902600IDA-hydrogen ion transmembrane transport24840010
GO:1903281IMP-positive regulation of calcium:sodium antiporter activity15105296
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SLC9A1CA210721512138085 Affinity Capture-Western; Reconstituted Complex
SLC9A1CA211243812138085 Affinity Capture-Western; Reconstituted Complex
SLC9A1CALM111243812809501 Far Western
SLC9A1CALM110725212809501 Far Western
SLC9A1MDFI11243816189514 Two-hybrid
SLC9A1MDFI11035316189514 Two-hybrid
CHPSLC9A11124388901634 11350981 12576672 Affinity Capture-Western; Far Western; Reconstituted Complex
CHPSLC9A11164218901634 11350981 12576672 Affinity Capture-Western; Far Western; Reconstituted Complex
TNIKSLC9A111243811369779 Reconstituted Complex
TNIKSLC9A111668211369779 Reconstituted Complex
TESCSLC9A111243811696366 12809501 Affinity Capture-Western; Far Western; Reconstituted Complex
TESCSLC9A112033011696366 12809501 Affinity Capture-Western; Far Western; Reconstituted Complex
CHP2SLC9A112199612576672 Affinity Capture-Western; Reconstituted Complex
CHP2SLC9A111243812576672 Affinity Capture-Western; Reconstituted Complex
WNK1SLC9A111243820936779 Two-hybrid
WNK1SLC9A112240320936779 Two-hybrid
MAP4K4SLC9A111483820936779 Two-hybrid
MAP4K4SLC9A111243820936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:102462
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080225-42'