AutismKB 2.0

Annotation Details for SLC11A1


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Basic Information Top
Gene Symbol:SLC11A1 ( LSH,NRAMP,NRAMP1 )
Gene Full Name: solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1
Band: 2q35
Quick LinksEntrez ID:6556; OMIM: 600266; Uniprot ID:NRAM1_HUMAN; ENSEMBL ID: ENSG00000018280; HGNC ID: 10907
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005764ISS-lysosome-
GO:0005770ISS-late endosome-
GO:0005886IMP-plasma membrane17932044
GO:0005886TAS-plasma membrane-
GO:0005887NAS-integral component of plasma membrane8537108
GO:0030670IDA-phagocytic vesicle membrane12070036
GO:0031902TAS-late endosome membrane-
GO:0070821IDA-tertiary granule membrane12070036
GO:0070821TAS-tertiary granule membrane-
GO:0101003TAS-ficolin-1-rich granule membrane-
GO ID Evidence Qualifier GO_term References
GO:0005384ISS-manganese ion transmembrane transporter activity-
GO:0042803IDA-protein homodimerization activity8537108
GO:0046915IGI-transition metal ion transmembrane transporter activity17932044
GO:0051139IGI-metal ion:proton antiporter activity17932044
GO:0051139TAS-metal ion:proton antiporter activity-
GO ID Evidence Qualifier GO_term References
GO:0001818ISS-negative regulation of cytokine production-
GO:0001819ISS-positive regulation of cytokine production-
GO:0002309ISS-T cell proliferation involved in immune response-
GO:0002369ISS-T cell cytokine production-
GO:0002606ISS-positive regulation of dendritic cell antigen processing and presentation-
GO:0002827ISS-positive regulation of T-helper 1 type immune response-
GO:0006826IMP-iron ion transport16510578
GO:0006828ISS-manganese ion transport-
GO:0006876IGI-cellular cadmium ion homeostasis17932044
GO:0006879IMP-cellular iron ion homeostasis16510578
GO:0006909ISS-phagocytosis-
GO:0006954ISS-inflammatory response-
GO:0007035ISS-vacuolar acidification-
GO:0009617IDA-response to bacterium7717395
GO:0010628ISS-positive regulation of gene expression-
GO:0015707ISS-nitrite transport-
GO:0019730TAS-antimicrobial humoral response-
GO:0032147ISS-activation of protein kinase activity-
GO:0032496ISS-response to lipopolysaccharide-
GO:0032623ISS-interleukin-2 production-
GO:0032632ISS-interleukin-3 production-
GO:0032729ISS-positive regulation of interferon-gamma production-
GO:0034341ISS-response to interferon-gamma-
GO:0042060ISS-wound healing-
GO:0042116ISS-macrophage activation-
GO:0042742ISS-defense response to bacterium-
GO:0042832ISS-defense response to protozoan-
GO:0043091ISS-L-arginine import-
GO:0043312TAS-neutrophil degranulation-
GO:0045342ISS-MHC class II biosynthetic process-
GO:0045454TAS-cell redox homeostasis-
GO:0045730ISS-respiratory burst-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048002ISS-antigen processing and presentation of peptide antigen-
GO:0048255ISS-mRNA stabilization-
GO:0050766ISS-positive regulation of phagocytosis-
GO:0050829ISS-defense response to Gram-negative bacterium-
GO:0055072ISS-iron ion homeostasis-
GO:0060586ISS-multicellular organismal iron ion homeostasis-
GO:0070574IGI-cadmium ion transmembrane transport17932044
GO:0070839ISS-divalent metal ion export17932044
GO:0071421IEA-manganese ion transmembrane transport-
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SLC11A1rs2276631, rs2279015, rs3731865 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1345275
  • Data Attributes: MGI curated and HomoloGene calculated
No data