AutismKB 2.0

Annotation Details for BMPR2


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Basic Information Top
Gene Symbol:BMPR2 ( BMPR-II,BMPR3,BMR2,BRK-3,FLJ41585,FLJ76945,PPH1,T-ALK )
Gene Full Name: bone morphogenetic protein receptor, type II (serine/threonine kinase)
Band: 2q33.1-q33.2
Quick LinksEntrez ID:659; OMIM: 600799; Uniprot ID:BMPR2_HUMAN; ENSEMBL ID: ENSG00000204217; HGNC ID: 1078
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space22664934
GO:0005654IDA-nucleoplasm-
GO:0005737IEA-cytoplasm-
GO:0005886IDA-plasma membrane15657086
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane12045205
GO:0005901IMPcolocalizes_withcaveola15657086
GO:0005913IDA-cell-cell adherens junction25468996
GO:0009925IEA-basal plasma membrane-
GO:0009986IEA-cell surface-
GO:0014069IEA-postsynaptic density-
GO:0016324IEA-apical plasma membrane-
GO:0030425IEA-dendrite-
GO:0043025IEA-neuronal cell body-
GO:0044214TAS-spanning component of plasma membrane9442116
GO ID Evidence Qualifier GO_term References
GO:0004702IEA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005515IPI-protein binding12045205
GO:0005524IEA-ATP binding-
GO:0016362TAS-activin receptor activity, type II-
GO:0019838IEA-growth factor binding-
GO:0036122IPI-BMP binding21976273
GO:0046872IEA-metal ion binding-
GO:0098821ISS-BMP receptor activity-
GO ID Evidence Qualifier GO_term References
GO:0001707ISS-mesoderm formation-
GO:0001893IEA-maternal placenta development-
GO:0001935IMP-endothelial cell proliferation25187962
GO:0001938IMP-positive regulation of endothelial cell proliferation17992660
GO:0001946ISS-lymphangiogenesis-
GO:0001974ISS-blood vessel remodeling-
GO:0002063IMP-chondrocyte development9442116
GO:0003085IMP-negative regulation of systemic arterial blood pressure18364108
GO:0003148ISS-outflow tract septum morphogenesis-
GO:0003148ISSNOToutflow tract septum morphogenesis-
GO:0003151ISS-outflow tract morphogenesis-
GO:0003181ISSNOTatrioventricular valve morphogenesis-
GO:0003183ISS-mitral valve morphogenesis-
GO:0003186ISS-tricuspid valve morphogenesis-
GO:0003197ISS-endocardial cushion development-
GO:0003252ISS-negative regulation of cell proliferation involved in heart valve morphogenesis-
GO:0006366IMP-transcription from RNA polymerase II promoter12045205
GO:0007178IDA-transmembrane receptor protein serine/threonine kinase signaling pathway12045205
GO:0007420IEA-brain development-
GO:0009267IEP-cellular response to starvation15657086
GO:0009952ISS-anterior/posterior pattern specification-
GO:0010595IMP-positive regulation of endothelial cell migration17992660
GO:0010634IDA-positive regulation of epithelial cell migration12819188
GO:0010862IMP-positive regulation of pathway-restricted SMAD protein phosphorylation17992660
GO:0014916IMP-regulation of lung blood pressure18364108
GO:0014916ISS-regulation of lung blood pressure-
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030166ISS-proteoglycan biosynthetic process-
GO:0030308IDA-negative regulation of cell growth12819188
GO:0030501IMP-positive regulation of bone mineralization18436533
GO:0030509IDA-BMP signaling pathway18436533
GO:0030509IMP-BMP signaling pathway9442116
GO:0030509ISS-BMP signaling pathway-
GO:0030509TAS-BMP signaling pathway-
GO:0030513IMP-positive regulation of BMP signaling pathway17992660
GO:0032924IEA-activin receptor signaling pathway-
GO:0042127IMP-regulation of cell proliferation11502704
GO:0045669IMP-positive regulation of osteoblast differentiation18436533
GO:0045778ISS-positive regulation of ossification-
GO:0045906ISS-negative regulation of vasoconstriction-
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18326817
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048010ISS-vascular endothelial growth factor receptor signaling pathway-
GO:0048286ISS-lung alveolus development-
GO:0048738ISSNOTcardiac muscle tissue development-
GO:0048842IEA-positive regulation of axon extension involved in axon guidance-
GO:0060173IEA-limb development-
GO:0060350ISS-endochondral bone morphogenesis-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060413ISS-atrial septum morphogenesis-
GO:0060836ISS-lymphatic endothelial cell differentiation-
GO:0060840ISS-artery development-
GO:0060841ISS-venous blood vessel development-
GO:0061036ISS-positive regulation of cartilage development-
GO:0061298ISS-retina vasculature development in camera-type eye-
GO:0061626ISS-pharyngeal arch artery morphogenesis-
GO:0061626ISSNOTpharyngeal arch artery morphogenesis-
GO:0071773IMP-cellular response to BMP stimulus18326817
GO:0072577IMP-endothelial cell apoptotic process25187962
GO:1902731IMP-negative regulation of chondrocyte proliferation9442116
GO:1905314ISS-semi-lunar valve development-
GO:2000279IMP-negative regulation of DNA biosynthetic process19366699
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BMPR2ACVR11071277791754 7890683 Affinity Capture-Western; Two-hybrid
BMPR2ACVR11066057791754 7890683 Affinity Capture-Western; Two-hybrid
BMPR2ACVR1B1071277791754 Two-hybrid
BMPR2ACVR1B1066067791754 Two-hybrid
BMPR2BMP21071277791754 10712517 10880444 Affinity Capture-Western; Reconstituted Complex
BMPR2BMP21071187791754 10712517 10880444 Affinity Capture-Western; Reconstituted Complex
BMPR2BMP41071277644468 Affinity Capture-Western
BMPR2BMP41071207644468 Affinity Capture-Western
BMPR2BMP610712710504300 Affinity Capture-Western
BMPR2BMP610712210504300 Affinity Capture-Western
BMPR2BMP71071277791754 Affinity Capture-Western
BMPR2BMP71071237791754 Affinity Capture-Western
BMPR2BMPR1A1071277791754 10712517 Affinity Capture-Western; Co-localization
BMPR2BMPR1A1071257791754 10712517 Affinity Capture-Western; Co-localization
BMPR2BMPR1B1071277791754 10712517 Affinity Capture-Western; Co-localization
BMPR2BMPR1B1071267791754 10712517 Affinity Capture-Western; Co-localization
TSR1BMPR21071277791754 Two-hybrid
TSR1BMPR21208427791754 Two-hybrid
TGFBR1BMPR21071277791754 7890683 Two-hybrid
TGFBR1BMPR21129047791754 7890683 Two-hybrid
GDF6BMPR21071279525338 Reconstituted Complex
GDF6BMPR21341479525338 Reconstituted Complex
GDF5BMPR21071279525338 Reconstituted Complex
GDF5BMPR21138399525338 Reconstituted Complex
BMPR2BMPR210712710712517 Affinity Capture-Western
GDF9BMPR210712712135884 Reconstituted Complex
GDF9BMPR210893012135884 Reconstituted Complex
LIMK1BMPR210712712963706 Affinity Capture-Western; Two-hybrid
LIMK1BMPR211017212963706 Affinity Capture-Western; Two-hybrid
FRS3BMPR210712715188402 Affinity Capture-MS
FRS3BMPR211603015188402 Affinity Capture-MS
CRYABBMPR210712715188402 Affinity Capture-MS
CRYABBMPR210780015188402 Affinity Capture-MS
CES3BMPR211704315188402 Affinity Capture-MS
CES3BMPR210712715188402 Affinity Capture-MS
GCGRBMPR210712715188402 Affinity Capture-MS
GCGRBMPR210891215188402 Affinity Capture-MS
FHL2BMPR210712719265191 Affinity Capture-Western; Two-hybrid
FHL2BMPR210856519265191 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1095407
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070618-1'