AutismKB 2.0

Annotation Details for SMARCA4


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Basic Information Top
Gene Symbol:SMARCA4 ( BAF190,BRG1,FLJ39786,RTPS2,SNF2,SNF2-BETA,SNF2L4,SNF2LB,SWI2,hSNF2b )
Gene Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Band: 19p13.2
Quick LinksEntrez ID:6597; OMIM: 603254; Uniprot ID:SMCA4_HUMAN; ENSEMBL ID: ENSG00000127616; HGNC ID: 11100
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin12065415
GO:0005615IDA-extracellular space22664934
GO:0005634IDA-nucleus8232556
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus22368283
GO:0016020IDA-membrane19946888
GO:0016514IDA-SWI/SNF complex8804307
GO:0043234IDA-protein complex16217013
GO:0071564IDA-npBAF complex18816825
GO:0071564ISS-npBAF complex-
GO:0071565ISS-nBAF complex-
GO ID Evidence Qualifier GO_term References
GO:0000978IDAcontributes_toRNA polymerase II core promoter proximal region sequence-specific DNA binding16217013
GO:0000980IDAcontributes_toRNA polymerase II distal enhancer sequence-specific DNA binding16217013
GO:0001105IDA-RNA polymerase II transcription coactivator activity15774904
GO:0001164IDA-RNA polymerase I CORE element sequence-specific DNA binding22368283
GO:0002039IPI-p53 binding11950834
GO:0003713IMP-transcription coactivator activity16687403
GO:0003713NAS-transcription coactivator activity8804307
GO:0003714IDA-transcription corepressor activity18487222
GO:0004386IEA-helicase activity-
GO:0005515IPI-protein binding10078207
GO:0005524IEA-ATP binding-
GO:0008094IGI-DNA-dependent ATPase activity8232556
GO:0008134IPI-transcription factor binding22368283
GO:0030957IPI-Tat protein binding16687403
GO:0031492IDAcontributes_tonucleosomal DNA binding16217013
GO:0047485IPI-protein N-terminus binding12917342
GO:0050681IPI-androgen receptor binding18487222
GO:0070182IPI-DNA polymerase binding19571879
GO:0070577IDA-lysine-acetylated histone binding17582821
GO ID Evidence Qualifier GO_term References
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter17938176
GO:0003407IEP-neural retina development18816825
GO:0006325TAS-chromatin organization-
GO:0006337IDA-nucleosome disassembly8895581
GO:0006338IC-chromatin remodeling18816825
GO:0006338IDA-chromatin remodeling10943845
GO:0006338IMP-chromatin remodeling22368283
GO:0006357NAS-regulation of transcription from RNA polymerase II promoter8804307
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007070TAS-negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle19149898
GO:0007399IEA-nervous system development-
GO:0016569IEA-covalent chromatin modification-
GO:0030177IMP-positive regulation of Wnt signaling pathway19571879
GO:0030308IMP-negative regulation of cell growth12065415
GO:0043044IDA-ATP-dependent chromatin remodeling16217013
GO:0043923IMP-positive regulation by host of viral transcription16687403
GO:0045892IDA-negative regulation of transcription, DNA-templated12065415
GO:0045892IMP-negative regulation of transcription, DNA-templated18487222
GO:0045893IMP-positive regulation of transcription, DNA-templated8208605
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15774904
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter8232556
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity11950834
GO:0060766IMP-negative regulation of androgen receptor signaling pathway18487222
GO:1901838IMP-positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter22368283
GO:1902661IDA-positive regulation of glucose mediated signaling pathway22368283
GO:1902895IMP-positive regulation of pri-miRNA transcription from RNA polymerase II promoter25569094
GO:1904837TAS-beta-catenin-TCF complex assembly-
GO:2000134TAS-negative regulation of G1/S transition of mitotic cell cycle19149898
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SMARCA4ACTB1124819845365 Affinity Capture-Western
SMARCA4ACTB1065759845365 Affinity Capture-Western
SMARCA4ACTL6A1124818895581 9845365 14559996 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCA4ACTL6A1066018895581 9845365 14559996 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCA4ADD111248117074803 Affinity Capture-Western
SMARCA4ADD110663117074803 Affinity Capture-Western
SMARCA4AHR10669911805098 Reconstituted Complex
SMARCA4AHR11248111805098 Reconstituted Complex
SMARCA4AR11248114966121 18487222 19762545 Affinity Capture-Western; Two-hybrid
SMARCA4AR10686214966121 18487222 19762545 Affinity Capture-Western; Two-hybrid
SMARCA4ATF310695714673171 Affinity Capture-Western
SMARCA4ATF311248114673171 Affinity Capture-Western
SMARCA4BRCA111248110943845 15034933 Affinity Capture-Western; Co-purification; Reconstituted Complex
SMARCA4BRCA110714010943845 15034933 Affinity Capture-Western; Co-purification; Reconstituted Complex
SMARCA4CCNE11124819891079 11085541 Affinity Capture-Western
SMARCA4CCNE11073389891079 11085541 Affinity Capture-Western
SMARCA4CDKN2A11248119149898 Affinity Capture-Western; Two-hybrid
SMARCA4CDKN2A10746319149898 Affinity Capture-Western; Two-hybrid
SMARCA4CDX211248119371634 Reconstituted Complex
SMARCA4CDX210747519371634 Reconstituted Complex
SMARCA4CEBPA11248116452305 Affinity Capture-Western; Reconstituted Complex
SMARCA4CEBPA10747916452305 Affinity Capture-Western; Reconstituted Complex
SMARCA4CEBPB11248117387179 Affinity Capture-Western
SMARCA4CEBPB10748017387179 Affinity Capture-Western
SMARCA4CHD411248111003653 14530259 16217013 Affinity Capture-Western; Two-hybrid
SMARCA4CHD410753311003653 14530259 16217013 Affinity Capture-Western; Two-hybrid
SMARCA4CREB111248116675956 Affinity Capture-Western
SMARCA4CREB110777516675956 Affinity Capture-Western
SMARCA4CREBBP1124819443979 9584200 11003650 Affinity Capture-Western; Co-fractionation; Phenotypic Enhancement
SMARCA4CREBBP1077779443979 9584200 11003650 Affinity Capture-Western; Co-fractionation; Phenotypic Enhancement
SMARCA4CTNNB111248111532957 Affinity Capture-Western; Two-hybrid
SMARCA4CTNNB110788011532957 Affinity Capture-Western; Two-hybrid
SMARCA4DDX511248117011493 Affinity Capture-Western
SMARCA4DDX510802117011493 Affinity Capture-Western
SMARCA4ESR11124819099865 11003650 Reconstituted Complex; Two-hybrid
SMARCA4ESR11084039099865 11003650 Reconstituted Complex; Two-hybrid
SMARCA4FANCA10847211726552 14499622 Affinity Capture-Western; Two-hybrid
SMARCA4FANCA11248111726552 14499622 Affinity Capture-Western; Two-hybrid
SMARCA4GATA111248111018012 Reconstituted Complex
SMARCA4GATA110889311018012 Reconstituted Complex
SMARCA4NR3C11124819128241 10688647 12917342 17387179 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
SMARCA4NR3C11091659128241 10688647 12917342 17387179 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
SMARCA4H2AFX11248116932743 Affinity Capture-Western
SMARCA4H2AFX10926816932743 Affinity Capture-Western
SMARCA4HDAC111248112192000 19081374 Affinity Capture-Western
SMARCA4HDAC110931512192000 19081374 Affinity Capture-Western
SMARCA4HDAC210931611238380 12192000 14559996 16800816 19081374 Affinity Capture-Western; Co-purification
SMARCA4HDAC211248111238380 12192000 14559996 16800816 19081374 Affinity Capture-Western; Co-purification
SMARCA4HIC111248119015639 Affinity Capture-Western; Reconstituted Complex
SMARCA4HIC110933719015639 Affinity Capture-Western; Reconstituted Complex
SMARCA4HIF1A11248115347669 Co-localization
SMARCA4HIF1A10933815347669 Co-localization
SMARCA4HNRNPC11248116217013 Affinity Capture-Western
SMARCA4HNRNPC10942416217013 Affinity Capture-Western
SMARCA4HSF110953011486022 Affinity Capture-Western
SMARCA4HSF111248111486022 Affinity Capture-Western
SMARCA4HSF410953216552721 Affinity Capture-Western; Reconstituted Complex
SMARCA4HSF411248116552721 Affinity Capture-Western; Reconstituted Complex
SMARCA4ING111248111784859 Affinity Capture-MS; Affinity Capture-Western
SMARCA4ING110983311784859 Affinity Capture-MS; Affinity Capture-Western
SMARCA4IRF111248116195385 Co-localization
SMARCA4IRF110986716195385 Co-localization
SMARCA4JUNB1124819128241 14673171 Affinity Capture-Western; Co-fractionation
SMARCA4JUNB1099299128241 14673171 Affinity Capture-Western; Co-fractionation
SMARCA4LMNB11124819128241 Co-fractionation
SMARCA4LMNB11101879128241 Co-fractionation
SMARCA4SMAD211248118003620 Affinity Capture-MS; Affinity Capture-Western
SMARCA4SMAD211026218003620 Affinity Capture-MS; Affinity Capture-Western
SMARCA4SMAD311248118003620 Affinity Capture-MS; Affinity Capture-Western
SMARCA4SMAD311026318003620 Affinity Capture-MS; Affinity Capture-Western
SMARCA4CIITA11248112077331 Reconstituted Complex
SMARCA4CIITA11041612077331 Reconstituted Complex
SMARCA4MYC11248111839798 14559996 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SMARCA4MYC11069411839798 14559996 17353931 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SMARCA4MYOD111248115870273 20195544 Affinity Capture-MS; Affinity Capture-Western
SMARCA4MYOD111073715870273 20195544 Affinity Capture-MS; Affinity Capture-Western
SMARCA4MYOG11248116424906 Affinity Capture-Western; Co-localization
SMARCA4MYOG11073916424906 Affinity Capture-Western; Co-localization
SMARCA4NEUROD111248116024661 Affinity Capture-Western
SMARCA4NEUROD111083316024661 Affinity Capture-Western
SMARCA4NF111248115999204 Affinity Capture-Western
SMARCA4NF111083615999204 Affinity Capture-Western
SMARCA4NFE2L211248116923960 Affinity Capture-Western
SMARCA4NFE2L211085216923960 Affinity Capture-Western
SMARCA4NONO11248118042045 Affinity Capture-Western; Reconstituted Complex
SMARCA4NONO11090418042045 Affinity Capture-Western; Reconstituted Complex
SMARCA4NR4A211248117043312 Affinity Capture-Western; Reconstituted Complex
SMARCA4NR4A211098317043312 Affinity Capture-Western; Reconstituted Complex
SMARCA4PAX611248116675956 Affinity Capture-Western
SMARCA4PAX611111416675956 Affinity Capture-Western
SMARCA4PBX111248115870273 Affinity Capture-Western
SMARCA4PBX111112015870273 Affinity Capture-Western
SMARCA4PCNA1124819443979 Co-fractionation
SMARCA4PCNA1111429443979 Co-fractionation
SMARCA4PHB11126412065415 15141164 Affinity Capture-Western
SMARCA4PHB11248112065415 15141164 Affinity Capture-Western
SMARCA4PMS211248117148452 Affinity Capture-MS
SMARCA4PMS211140417148452 Affinity Capture-MS
SMARCA4POLR2A1124818895581 9128241 9845365 11238380 15999204 16195385 Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification
SMARCA4POLR2A1114268895581 9128241 9845365 11238380 15999204 16195385 Affinity Capture-Western; Co-fractionation; Co-localization; Co-purification
SMARCA4RB11124817923370 9128241 10778858 15485920 17666433 19081374 Affinity Capture-Western; Co-fractionation
SMARCA4RB11118607923370 9128241 10778858 15485920 17666433 19081374 Affinity Capture-Western; Co-fractionation
SMARCA4RBBP411186311238380 Co-purification
SMARCA4RBBP411248111238380 Co-purification
SMARCA4RELB11190314743216 Affinity Capture-MS
SMARCA4RELB11248114743216 Affinity Capture-MS
SMARCA4REST11191012192000 17023429 Affinity Capture-Western
SMARCA4REST11248112192000 17023429 Affinity Capture-Western
SMARCA4RFC11119139443979 Co-fractionation
SMARCA4RFC11124819443979 Co-fractionation
SMARCA4RPA11124819443979 Co-fractionation
SMARCA4RPA11120379443979 Co-fractionation
SMARCA4RXRA11248115774904 Affinity Capture-Western
SMARCA4RXRA11216815774904 Affinity Capture-Western
SMARCA4SMARCA21124799128241 14559996 18042045 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
SMARCA4SMARCA21124819128241 14559996 18042045 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
SMARCB1SMARCA41124828895581 9128241 9584200 9744861 9845365 11238380 11486022 11726552 14559996 15150092 16287714 18042045 18414052 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification
SMARCB1SMARCA41124818895581 9128241 9584200 9744861 9845365 11238380 11486022 11726552 14559996 15150092 16287714 18042045 18414052 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Co-purification
SMARCC1SMARCA41124838895581 9584200 9845365 11238380 11726552 14559996 16217013 16230384 16287714 16452305 18086889 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCC1SMARCA41124818895581 9584200 9845365 11238380 11726552 14559996 16217013 16230384 16287714 16452305 18086889 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCC2SMARCA41124858895581 9845365 11726552 14559996 18086889 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCC2SMARCA41124818895581 9845365 11726552 14559996 18086889 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCE1SMARCA41124898895581 9845365 11003653 12192000 14559996 16287714 16940996 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
SMARCE1SMARCA41124818895581 9845365 11003653 12192000 14559996 16287714 16940996 18809673 Affinity Capture-MS; Affinity Capture-Western; Co-purification
ARID1ASMARCA41124818895581 9845365 14559996 15170388 16287714 18086889 Affinity Capture-MS; Affinity Capture-Western; Co-purification
ARID1ASMARCA41138948895581 9845365 14559996 15170388 16287714 18086889 Affinity Capture-MS; Affinity Capture-Western; Co-purification
NCOR2SMARCA411497410944117 Co-fractionation
NCOR2SMARCA411248110944117 Co-fractionation
NCOA1SMARCA411420011003650 Phenotypic Enhancement
NCOA1SMARCA411248111003650 Phenotypic Enhancement
NCOR1SMARCA411248111013263 Co-purification
NCOR1SMARCA411497311013263 Co-purification
SP1SMARCA411255011018012 12192045 15317818 Affinity Capture-Western; Reconstituted Complex
SP1SMARCA411248111018012 12192045 15317818 Affinity Capture-Western; Reconstituted Complex
KLF1SMARCA411590411018012 Reconstituted Complex
KLF1SMARCA411248111018012 Reconstituted Complex
SIN3ASMARCA411743911238380 11784859 14559996 16800816 19081374 Affinity Capture-Western; Co-purification; Reconstituted Complex
SIN3ASMARCA411248111238380 11784859 14559996 16800816 19081374 Affinity Capture-Western; Co-purification; Reconstituted Complex
PABPN1SMARCA411377711371506 Two-hybrid
PABPN1SMARCA411248111371506 Two-hybrid
STK11SMARCA411267011445556 Affinity Capture-Western; Reconstituted Complex
STK11SMARCA411248111445556 Affinity Capture-Western; Reconstituted Complex
HSP90B1SMARCA411303611726552 Affinity Capture-Western
HSP90B1SMARCA411248111726552 Affinity Capture-Western
TP53SMARCA411248111950834 17666433 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
TP53SMARCA411301011950834 17666433 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
ARID1BSMARCA411248111988099 12200431 15170388 20086098 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ARID1BSMARCA412155911988099 12200431 15170388 20086098 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MED17SMARCA411483012154023 Co-purification
MED17SMARCA411248112154023 Co-purification
RCOR1SMARCA411679612192000 Affinity Capture-Western
RCOR1SMARCA411248112192000 Affinity Capture-Western
STAT2SMARCA411265012244326 Affinity Capture-Western; Reconstituted Complex
STAT2SMARCA411248112244326 Affinity Capture-Western; Reconstituted Complex
CBX5SMARCA411703012411497 15882967 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CBX5SMARCA411248112411497 15882967 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VDRSMARCA411248112837248 16252006 Affinity Capture-Western
VDRSMARCA411326412837248 16252006 Affinity Capture-Western
BRWD1SMARCA411982812889071 Affinity Capture-Western
BRWD1SMARCA411248112889071 Affinity Capture-Western
SMARCD1SMARCA411248612917342 14559996 18042045 Affinity Capture-MS; Affinity Capture-Western
SMARCD1SMARCA411248112917342 14559996 18042045 Affinity Capture-MS; Affinity Capture-Western
SMARCD2SMARCA411248714559996 Affinity Capture-MS
SMARCD2SMARCA411248114559996 Affinity Capture-MS
PRMT5SMARCA411568814559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
PRMT5SMARCA411248114559996 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SIN3BSMARCA411248114559996 Reconstituted Complex
SIN3BSMARCA411690114559996 Reconstituted Complex
CARM1SMARCA411576014729568 Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex
CARM1SMARCA411248114729568 Affinity Capture-Western; Co-purification; Far Western; Reconstituted Complex
MPP6SMARCA411967515231747 Two-hybrid
MPP6SMARCA411248115231747 Two-hybrid
STAT3SMARCA411265115286705 Affinity Capture-Western; Reconstituted Complex
STAT3SMARCA411248115286705 Affinity Capture-Western; Reconstituted Complex
NR1H2SMARCA411248115774904 Affinity Capture-Western
NR1H2SMARCA411322215774904 Affinity Capture-Western
MYEF2SMARCA411912415870273 16424906 Affinity Capture-Western; Co-localization
MYEF2SMARCA411248115870273 16424906 Affinity Capture-Western; Co-localization
NEUROG2SMARCA412202016024661 Affinity Capture-Western
NEUROG2SMARCA411248116024661 Affinity Capture-Western
GMNNSMARCA411924616024661 Affinity Capture-Western; Reconstituted Complex
GMNNSMARCA411248116024661 Affinity Capture-Western; Reconstituted Complex
ZMIZ2SMARCA411248116051670 Affinity Capture-Western
ZMIZ2SMARCA412370116051670 Affinity Capture-Western
STAT1SMARCA411264916195385 Co-localization
STAT1SMARCA411248116195385 Co-localization
USF1SMARCA411323716195385 Co-localization
USF1SMARCA411248116195385 Co-localization
TCF3SMARCA411279116252006 Affinity Capture-Western; Co-localization
TCF3SMARCA411248116252006 Affinity Capture-Western; Co-localization
BAZ1BSMARCA411449716252006 Affinity Capture-Western; Co-localization
BAZ1BSMARCA411248116252006 Affinity Capture-Western; Co-localization
ZMYND8SMARCA411714616565076 Affinity Capture-Western
ZMYND8SMARCA411248116565076 Affinity Capture-Western
STAT5ASMARCA411265317387179 Affinity Capture-Western
STAT5ASMARCA411248117387179 Affinity Capture-Western
TAF10SMARCA411274417643375 Affinity Capture-MS
TAF10SMARCA411248117643375 Affinity Capture-MS
ADNPSMARCA411696717878164 Affinity Capture-MS; Affinity Capture-Western
ADNPSMARCA411248117878164 Affinity Capture-MS; Affinity Capture-Western
BCL7CSMARCA411469118809673 Affinity Capture-MS
BCL7CSMARCA411248118809673 Affinity Capture-MS
BRD7SMARCA411888318809673 Affinity Capture-Western
BRD7SMARCA411248118809673 Affinity Capture-Western
CDYLSMARCA411481819061646 Affinity Capture-MS
CDYLSMARCA411248119061646 Affinity Capture-MS
HDAC3SMARCA411248119081374 Affinity Capture-Western
HDAC3SMARCA411436819081374 Affinity Capture-Western
SS18L1SMARCA411750519081374 Affinity Capture-Western; Reconstituted Complex
SS18L1SMARCA411248119081374 Affinity Capture-Western; Reconstituted Complex
SRFSMARCA411260019342595 Affinity Capture-Western
SRFSMARCA411248119342595 Affinity Capture-Western
MYOCDSMARCA412504419342595 Affinity Capture-Western; Reconstituted Complex
MYOCDSMARCA411248119342595 Affinity Capture-Western; Reconstituted Complex
MCPH1SMARCA412277619525936 Affinity Capture-MS; Affinity Capture-Western
MCPH1SMARCA411248119525936 Affinity Capture-MS; Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
SMARCA4PHB5491212065415 Prohibitin interacts with Brg-1
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88192
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030605-1'