AutismKB 2.0

Annotation Details for SMO


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Basic Information Top
Gene Symbol:SMO ( Gx,SMOH )
Gene Full Name: smoothened homolog (Drosophila)
Band: 7q32.1
Quick LinksEntrez ID:6608; OMIM: 601500; Uniprot ID:SMO_HUMAN; ENSEMBL ID: ENSG00000128602; HGNC ID: 11119
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005794IDAcolocalizes_withGolgi apparatus11278759
GO:0005886IDA-plasma membrane19304771
GO:0005901IDAcolocalizes_withcaveola11278759
GO:0005929ISS-cilium-
GO:0005929TAS-cilium21931618
GO:0016021IEA-integral component of membrane-
GO:0030666TAS-endocytic vesicle membrane-
GO:0043231IDA-intracellular membrane-bounded organelle11278759
GO:0060170TAS-ciliary membrane-
GO:0070062IDA-extracellular exosome19056867
GO:0097542TAS-ciliary tip-
GO ID Evidence Qualifier GO_term References
GO:0004930IEA-G-protein coupled receptor activity-
GO:0005113IPI-patched binding9811851
GO:0005515IPI-protein binding19592253
GO:0008144IDA-drug binding19304771
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001570IEA-vasculogenesis-
GO:0001649IEA-osteoblast differentiation-
GO:0001701IEA-in utero embryonic development-
GO:0001708IEA-cell fate specification-
GO:0001755IEA-neural crest cell migration-
GO:0001947ISS-heart looping-
GO:0002052IEA-positive regulation of neuroblast proliferation-
GO:0002053IEA-positive regulation of mesenchymal cell proliferation-
GO:0003140ISS-determination of left/right asymmetry in lateral mesoderm-
GO:0003323IEA-type B pancreatic cell development-
GO:0007186IEA-G-protein coupled receptor signaling pathway-
GO:0007224IEP-smoothened signaling pathway17850284
GO:0007224IMP-smoothened signaling pathway9422511
GO:0007228ISS-positive regulation of hh target transcription factor activity-
GO:0007371ISS-ventral midline determination-
GO:0007494ISS-midgut development-
GO:0009952IEA-anterior/posterior pattern specification-
GO:0010628ISS-positive regulation of gene expression-
GO:0010629ISS-negative regulation of gene expression-
GO:0021542IEA-dentate gyrus development-
GO:0021696IEA-cerebellar cortex morphogenesis-
GO:0021794IEA-thalamus development-
GO:0021904IEA-dorsal/ventral neural tube patterning-
GO:0021910IEA-smoothened signaling pathway involved in ventral spinal cord patterning-
GO:0021938IEA-smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation-
GO:0021953IEA-central nervous system neuron differentiation-
GO:0021987IEA-cerebral cortex development-
GO:0030857IEA-negative regulation of epithelial cell differentiation-
GO:0031069IEA-hair follicle morphogenesis-
GO:0034504IEA-protein localization to nucleus-
GO:0035264IEA-multicellular organism growth-
GO:0040018IEA-positive regulation of multicellular organism growth-
GO:0042307IEA-positive regulation of protein import into nucleus-
GO:0042475IEA-odontogenesis of dentin-containing tooth-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043392ISS-negative regulation of DNA binding-
GO:0045880IEA-positive regulation of smoothened signaling pathway-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046622IEA-positive regulation of organ growth-
GO:0048143IEA-astrocyte activation-
GO:0048741IEA-skeletal muscle fiber development-
GO:0048853ISS-forebrain morphogenesis-
GO:0048873IEA-homeostasis of number of cells within a tissue-
GO:0050679IEA-positive regulation of epithelial cell proliferation-
GO:0050821IEA-protein stabilization-
GO:0051451IEA-myoblast migration-
GO:0051799IEA-negative regulation of hair follicle development-
GO:0060248IMP-detection of cell density by contact stimulus involved in contact inhibition9422511
GO:0060413IEA-atrial septum morphogenesis-
GO:0060644IEA-mammary gland epithelial cell differentiation-
GO:0060684IEA-epithelial-mesenchymal cell signaling-
GO:0061053ISS-somite development-
GO:0061113IEA-pancreas morphogenesis-
GO:0070986IEA-left/right axis specification-
GO:0071397ISS-cellular response to cholesterol-
GO:0072001IEP-renal system development17850284
GO:0072285ISS-mesenchymal to epithelial transition involved in metanephric renal vesicle formation-
GO:0090190ISS-positive regulation of branching involved in ureteric bud morphogenesis-
GO:2000036IEA-regulation of stem cell population maintenance-
GO:2000826ISS-regulation of heart morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SMOPTCH11124929811851 Affinity Capture-Western
SMOPTCH11116999811851 Affinity Capture-Western
PTCH2SMO1124929811851 Affinity Capture-Western
PTCH2SMO1141959811851 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
SMOARRB218281615618519 Beta-arr2 interacts with Smo. This interaction was modeled on a demonstrated interaction between Beta-arr2 and Smo both from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:108075
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-89'