AutismKB 2.0

Annotation Details for SMPD1


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Basic Information Top
Gene Symbol:SMPD1 ( ASM,ASMASE,NPD )
Gene Full Name: sphingomyelin phosphodiesterase 1, acid lysosomal
Band: 11p15.4
Quick LinksEntrez ID:6609; OMIM: 607608; Uniprot ID:ASM_HUMAN; ENSEMBL ID: ENSG00000166311; HGNC ID: 11120
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005615IDA-extracellular space8702487
GO:0005764IDA-lysosome18815062
GO:0005768IDA-endosome20956541
GO:0005886IDA-plasma membrane20956541
GO:0042599IEA-lamellar body-
GO:0043202TAS-lysosomal lumen-
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004767TAS-sphingomyelin phosphodiesterase activity-
GO:0005515IPI-protein binding21157428
GO:0008270IDA-zinc ion binding8702487
GO:0016798IEA-hydrolase activity, acting on glycosyl bonds-
GO:0061750IDA-acid sphingomyelin phosphodiesterase activity8702487
GO ID Evidence Qualifier GO_term References
GO:0006684TAS-sphingomyelin metabolic process7670466
GO:0006685IDA-sphingomyelin catabolic process18815062
GO:0006687TAS-glycosphingolipid metabolic process-
GO:0007165TAS-signal transduction7670466
GO:0007399TAS-nervous system development7670466
GO:0023021IMP-termination of signal transduction19279008
GO:0035307IMP-positive regulation of protein dephosphorylation19279008
GO:0042220IEA-response to cocaine-
GO:0042493IEA-response to drug-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043407IMP-negative regulation of MAP kinase activity19279008
GO:0046513IDA-ceramide biosynthetic process18815062
GO:0046513IMP-ceramide biosynthetic process19279011
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98325
  • Data Attributes: MGI curated and HomoloGene calculated
No data