AutismKB 2.0

Annotation Details for SOAT1


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Basic Information Top
Gene Symbol:SOAT1 ( ACACT,ACAT,ACAT1,RP11-215I23.2,SOAT,STAT )
Gene Full Name: sterol O-acyltransferase 1
Band: 1q25.2
Quick LinksEntrez ID:6646; OMIM: 102642; Uniprot ID:SOAT1_HUMAN; ENSEMBL ID: ENSG00000057252; HGNC ID: 11177
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005783IDA-endoplasmic reticulum10623671
GO:0005789IDA-endoplasmic reticulum membrane17412327
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0016020IDA-membrane9756919
GO:0016021IEA-integral component of membrane-
GO ID Evidence Qualifier GO_term References
GO:0000062IDA-fatty-acyl-CoA binding16647063
GO:0004772IDA-sterol O-acyltransferase activity9756919
GO:0004772IMP-sterol O-acyltransferase activity8407899
GO:0005515IPI-protein binding21044950
GO:0015485IDA-cholesterol binding16647063
GO:0034736IDA-cholesterol O-acyltransferase activity16647063
GO:0034736IMP-cholesterol O-acyltransferase activity8407899
GO:0034736TAS-cholesterol O-acyltransferase activity-
GO ID Evidence Qualifier GO_term References
GO:0008203IDA-cholesterol metabolic process9756919
GO:0008203IMP-cholesterol metabolic process8407899
GO:0010742IC-macrophage derived foam cell differentiation8407899
GO:0010742IMP-macrophage derived foam cell differentiation15353128
GO:0010742NAS-macrophage derived foam cell differentiation18971559
GO:0010878IMP-cholesterol storage8407899
GO:0033344IMP-cholesterol efflux15308631
GO:0034379IMP-very-low-density lipoprotein particle assembly15308631
GO:0034383TAS-low-density lipoprotein particle clearance-
GO:0034435IDA-cholesterol esterification16647063
GO:0034435IMP-cholesterol esterification8407899
GO:0042632TAS-cholesterol homeostasis11401500
GO:0042986IMP-positive regulation of amyloid precursor protein biosynthetic process17412327
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SOAT1rs1044925, rs1543876, rs2152318, rs2152320, rs2247071, rs2862616, rs3753526 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:104665
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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