AutismKB 2.0

Annotation Details for SOS2


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Basic Information Top
Gene Symbol:SOS2 ( FLJ25596 )
Gene Full Name: son of sevenless homolog 2 (Drosophila)
Band: 14q21.3
Quick LinksEntrez ID:6655; OMIM: 601247; Uniprot ID:SOS2_HUMAN; ENSEMBL ID: ENSG00000100485; HGNC ID: 11188
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding7629138
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051057IEA-positive regulation of small GTPase mediated signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOS2EGFR11253810675333 Affinity Capture-Western
SOS2EGFR10827610675333 Affinity Capture-Western
SOS2GRB21125387629138 10940929 20936779 Affinity Capture-Western; Two-hybrid
SOS2GRB21091427629138 10940929 20936779 Affinity Capture-Western; Two-hybrid
SOS2PLCG111253810940929 Affinity Capture-Western; Two-hybrid
SOS2PLCG111135110940929 Affinity Capture-Western; Two-hybrid
SOS2SHC111236110675333 Affinity Capture-Western
SOS2SHC111253810675333 Affinity Capture-Western
GRAP2SOS211253810820259 Reconstituted Complex
GRAP2SOS211479910820259 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
SOS2rs2227276, rs8192699 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:98355
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090319-5'