AutismKB 2.0

Annotation Details for SOX2


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Basic Information Top
Gene Symbol:SOX2 ( ANOP3,MCOPS3,MGC2413 )
Gene Full Name: SRY (sex determining region Y)-box 2
Band: 3q26.33
Quick LinksEntrez ID:6657; OMIM: 184429; Uniprot ID:SOX2_HUMAN; ENSEMBL ID: ENSG00000181449; HGNC ID: 11195
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus16153702
GO:0005634IDA-nucleus17291498
GO:0005634NAS-nucleus7849401
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667TAS-transcription factor complex19736317
GO:0005737IDA-cytoplasm18027866
GO:0005829IDA-cytosol18000303
GO ID Evidence Qualifier GO_term References
GO:0000976IEA-transcription regulatory region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677IDA-DNA binding16153702
GO:0003677NAS-DNA binding7849401
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding16153702
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding7849401
GO:0005515IPI-protein binding18456656
GO:0035198IDA-miRNA binding18710938
GO:0043565IDA-sequence-specific DNA binding20713518
GO:0044212IDA-transcription regulatory region DNA binding18407919
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001649IDA-osteoblast differentiation18187129
GO:0001654IEP-eye development18285410
GO:0001714IDA-endodermal cell fate specification21245162
GO:0006325NAS-chromatin organization7849401
GO:0006355IDA-regulation of transcription, DNA-templated16153702
GO:0006355NAS-regulation of transcription, DNA-templated7849401
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0007050IDA-cell cycle arrest18268498
GO:0009611IEP-response to wounding17982423
GO:0010468IMP-regulation of gene expression18388306
GO:0021781NAS-glial cell fate commitment17291498
GO:0021983IEP-pituitary gland development18285410
GO:0021984IEA-adenohypophysis development-
GO:0022409IEA-positive regulation of cell-cell adhesion-
GO:0030900IEP-forebrain development18285410
GO:0035019IDA-somatic stem cell population maintenance19409607
GO:0035019IMP-somatic stem cell population maintenance18388306
GO:0035019TAS-somatic stem cell population maintenance-
GO:0042246IEA-tissue regeneration-
GO:0043281IDA-regulation of cysteine-type endopeptidase activity involved in apoptotic process18268498
GO:0043410IDA-positive regulation of MAPK cascade18187129
GO:0045597IEA-positive regulation of cell differentiation-
GO:0045665ISS-negative regulation of neuron differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated18407919
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter18027866
GO:0048839IEP-inner ear development18407919
GO:0050680IDA-negative regulation of epithelial cell proliferation18268498
GO:0070848IDA-response to growth factor18187129
GO:0090090IDA-negative regulation of canonical Wnt signaling pathway18285410
GO:0097150ISS-neuronal stem cell population maintenance-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOX2PAX611254012710953 Affinity Capture-Western
SOX2PAX611111412710953 Affinity Capture-Western
SOX2POU5F111254012923055 Reconstituted Complex
SOX2POU5F111145612923055 Reconstituted Complex
ALX4SOX211254020211142 Two-hybrid
ALX4SOX212193820211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98364
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030909-1'