AutismKB 2.0

Annotation Details for SOX4


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Basic Information Top
Gene Symbol:SOX4 ( EVI16 )
Gene Full Name: SRY (sex determining region Y)-box 4
Band: 6p22.3
Quick LinksEntrez ID:6659; OMIM: 184430; Uniprot ID:SOX4_HUMAN; ENSEMBL ID: ENSG00000124766; HGNC ID: 11200
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16631117
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm17875931
GO:0005739IDA-mitochondrion-
GO:0044798IEA-nuclear transcription factor complex-
GO ID Evidence Qualifier GO_term References
GO:0000976ISS-transcription regulatory region sequence-specific DNA binding-
GO:0001046IDA-core promoter sequence-specific DNA binding20049565
GO:0001071IMP-nucleic acid binding transcription factor activity20049565
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding19147588
GO:0001105ISS-RNA polymerase II transcription coactivator activity-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding7706298
GO:0005515IPI-protein binding16631117
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0001501ISS-skeletal system development-
GO:0001841ISS-neural tube formation-
GO:0002328ISS-pro-B cell differentiation-
GO:0003183ISS-mitral valve morphogenesis-
GO:0003211ISS-cardiac ventricle formation-
GO:0003215ISS-cardiac right ventricle morphogenesis-
GO:0003289ISS-atrial septum primum morphogenesis-
GO:0003357ISS-noradrenergic neuron differentiation-
GO:0006355IDA-regulation of transcription, DNA-templated7706298
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006977IMP-DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest19234109
GO:0007507ISS-heart development-
GO:0008284IMP-positive regulation of cell proliferation17875931
GO:0008285IMP-negative regulation of cell proliferation19234109
GO:0014009ISS-glial cell proliferation-
GO:0021510ISS-spinal cord development-
GO:0021522ISS-spinal cord motor neuron differentiation-
GO:0021782ISS-glial cell development-
GO:0030177ISS-positive regulation of Wnt signaling pathway-
GO:0030217ISS-T cell differentiation-
GO:0031018IEA-endocrine pancreas development-
GO:0031397IMP-negative regulation of protein ubiquitination19234109
GO:0031647IMP-regulation of protein stability19234109
GO:0032024ISS-positive regulation of insulin secretion-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035910ISS-ascending aorta morphogenesis-
GO:0042593ISS-glucose homeostasis-
GO:0042769IDA-DNA damage response, detection of DNA damage19234109
GO:0043065IMP-positive regulation of apoptotic process15522200
GO:0045727IMP-positive regulation of translation19234109
GO:0045893IDA-positive regulation of transcription, DNA-templated16631117
GO:0045893IMP-positive regulation of transcription, DNA-templated19234109
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter19147588
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter20049565
GO:0046826IMP-negative regulation of protein export from nucleus19234109
GO:0048485ISS-sympathetic nervous system development-
GO:0050821IMP-protein stabilization17875931
GO:0060070ISS-canonical Wnt signaling pathway-
GO:0060174ISS-limb bud formation-
GO:0060412ISS-ventricular septum morphogenesis-
GO:0060548ISS-negative regulation of cell death-
GO:0060563ISS-neuroepithelial cell differentiation-
GO:0060993ISS-kidney morphogenesis-
GO:0071333ISS-cellular response to glucose stimulus-
GO:0090263ISS-positive regulation of canonical Wnt signaling pathway-
GO:2000761IDA-positive regulation of N-terminal peptidyl-lysine acetylation19234109
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SOX4SDCBP11254211498591 Affinity Capture-Western; Reconstituted Complex
SOX4SDCBP11228711498591 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98366
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8290'