AutismKB 2.0

Annotation Details for SP3


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Basic Information Top
Gene Symbol:SP3 ( DKFZp686O1631,SPR2 )
Gene Full Name: Sp3 transcription factor
Band: 2q31.1
Quick LinksEntrez ID:6670; OMIM: 601804; Uniprot ID:SP3_HUMAN; ENSEMBL ID: ENSG00000172845; HGNC ID: 11208
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005634IC-nucleus12560508
GO:0005654TAS-nucleoplasm-
GO:0016605IEA-PML body-
GO:0017053IEA-transcriptional repressor complex-
GO ID Evidence Qualifier GO_term References
GO:0000977IDA-RNA polymerase II regulatory region sequence-specific DNA binding14979875
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0000987IEA-core promoter proximal region sequence-specific DNA binding-
GO:0001078IEA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003682IEA-chromatin binding-
GO:0005515IPI-protein binding10391891
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001503IEA-ossification-
GO:0001779IEA-natural killer cell differentiation-
GO:0001829IEA-trophectodermal cell differentiation-
GO:0001889IEA-liver development-
GO:0001892IEA-embryonic placenta development-
GO:0006351IEA-transcription, DNA-templated-
GO:0006355IDA-regulation of transcription, DNA-templated12560508
GO:0016925TAS-protein sumoylation-
GO:0030183IEA-B cell differentiation-
GO:0030217IEA-T cell differentiation-
GO:0030219IEA-megakaryocyte differentiation-
GO:0030224IEA-monocyte differentiation-
GO:0030324IEA-lung development-
GO:0030851IEA-granulocyte differentiation-
GO:0043353IEA-enucleate erythrocyte differentiation-
GO:0045892IMP-negative regulation of transcription, DNA-templated20091743
GO:0045892NAS-negative regulation of transcription, DNA-templated9278495
GO:0045893IDA-positive regulation of transcription, DNA-templated12771217
GO:0045893NAS-positive regulation of transcription, DNA-templated9278495
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter14979875
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter14979875
GO:0048596IEA-embryonic camera-type eye morphogenesis-
GO:0048706IEA-embryonic skeletal system development-
GO:0060136IEA-embryonic process involved in female pregnancy-
GO:0060216IEA-definitive hemopoiesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SP3CEBPB11255316651265 Affinity Capture-Western
SP3CEBPB10748016651265 Affinity Capture-Western
SP3CREBBP11255316734381 Affinity Capture-Western
SP3CREBBP10777716734381 Affinity Capture-Western
SP3CRX10779615781457 Affinity Capture-Western
SP3CRX11255315781457 Affinity Capture-Western
SP3DNMT111255317124180 Affinity Capture-Western
SP3DNMT110812317124180 Affinity Capture-Western
SP3E2F110820110547281 Affinity Capture-Western; Reconstituted Complex
SP3E2F111255310547281 Affinity Capture-Western; Reconstituted Complex
SP3EP30011255311517158 12200149 16734381 Affinity Capture-Western
SP3EP30010834711517158 12200149 16734381 Affinity Capture-Western
SP3ESR111255316651265 Affinity Capture-Western
SP3ESR110840316651265 Affinity Capture-Western
SP3GABPA11255311237613 Affinity Capture-Western; Reconstituted Complex
SP3GABPA10882611237613 Affinity Capture-Western; Reconstituted Complex
SP3HDAC111255311517158 12176973 12200149 16734381 17906119 Affinity Capture-Western
SP3HDAC110931511517158 12176973 12200149 16734381 17906119 Affinity Capture-Western
SP3HDAC210931612151407 12176973 Affinity Capture-Western
SP3HDAC211255312151407 12176973 Affinity Capture-Western
SP3NKX3-111255316201967 Two-hybrid
SP3NKX3-111088816201967 Two-hybrid
SP3RBBP411255312091390 Affinity Capture-Western
SP3RBBP411186312091390 Affinity Capture-Western
SP3SFPQ11255319339282 Affinity Capture-Western
SP3SFPQ11231919339282 Affinity Capture-Western
SP3SP111255011517158 12200149 16734381 Affinity Capture-Western
SP3SP111255311517158 12200149 16734381 Affinity Capture-Western
SP4SP31125537559627 Phenotypic Suppression
SP4SP31125547559627 Phenotypic Suppression
PIAS1SP311412412356736 Reconstituted Complex; Two-hybrid
PIAS1SP311255312356736 Reconstituted Complex; Two-hybrid
TP53SP311255312665570 Affinity Capture-Western
TP53SP311301012665570 Affinity Capture-Western
STK19SP311255314667819 Two-hybrid
STK19SP311438314667819 Two-hybrid
ZBTB7BSP311924217698844 Affinity Capture-Western
ZBTB7BSP311255317698844 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1277166
  • Data Attributes: MGI curated and HomoloGene calculated
No data