AutismKB 2.0

Annotation Details for SP100


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Basic Information Top
Gene Symbol:SP100 ( DKFZp686E07254,FLJ00340,FLJ34579 )
Gene Full Name: SP100 nuclear antigen
Band: 2q37.1
Quick LinksEntrez ID:6672; OMIM: 604585; Uniprot ID:SP100_HUMAN; ENSEMBL ID: ENSG00000067066; HGNC ID: 11206
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region19135898
GO:0005634IDA-nucleus8810287
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm17245429
GO:0016604IDA-nuclear body-
GO:0016605IDA-PML body9230084
GO:0030870IDAcolocalizes_withMre11 complex15767676
GO ID Evidence Qualifier GO_term References
GO:0003677IEA-DNA binding-
GO:0003713IDA-transcription coactivator activity14647468
GO:0003714IDA-transcription corepressor activity15247905
GO:0005515IPI-protein binding9636147
GO:0019900IPI-kinase binding14647468
GO:0019904IPI-protein domain specific binding9636147
GO:0042803IPI-protein homodimerization activity9636146
GO:0070087IPI-chromo shadow domain binding15882967
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15247905
GO:0000723IMP-telomere maintenance15767676
GO:0006351IEA-transcription, DNA-templated-
GO:0006978IDA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator14647468
GO:0010596IMP-negative regulation of endothelial cell migration15592518
GO:0016032IEA-viral process-
GO:0034340IDA-response to type I interferon9230084
GO:0034340IMP-response to type I interferon8810287
GO:0034341IDA-response to interferon-gamma9230084
GO:0034341IMP-response to interferon-gamma8810287
GO:0043392IDA-negative regulation of DNA binding15247905
GO:0043433IDA-negative regulation of sequence-specific DNA binding transcription factor activity15247905
GO:0045185IDA-maintenance of protein location12470659
GO:0045765IMP-regulation of angiogenesis15592518
GO:0045893IMP-positive regulation of transcription, DNA-templated14647468
GO:0046826IMP-negative regulation of protein export from nucleus17245429
GO:0051271IMP-negative regulation of cellular component movement15247905
GO:0060333IC-interferon-gamma-mediated signaling pathway8810287
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060337IC-type I interferon signaling pathway8810287
GO:1902041IMP-regulation of extrinsic apoptotic signaling pathway via death domain receptors17245429
GO:1902044IMP-regulation of Fas signaling pathway17245429
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SP100MX111068411716541 Two-hybrid
SP100MX111255511716541 Two-hybrid
SP100MYB11255520211142 Two-hybrid
SP100MYB11068720211142 Two-hybrid
CBX5SP1001170309636146 11313457 15882967 Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
CBX5SP1001125559636146 11313457 15882967 Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
CBX3SP1001164639636146 9636147 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CBX3SP1001125559636146 9636147 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CBX1SP1001125559636146 Two-hybrid
CBX1SP1001161519636146 Two-hybrid
UBA2SP10011536511792325 Biochemical Activity
UBA2SP10011255511792325 Biochemical Activity
SAE1SP10011536611792325 Biochemical Activity
SAE1SP10011255511792325 Biochemical Activity
HIPK2SP10011881514647468 Affinity Capture-Western
HIPK2SP10011255514647468 Affinity Capture-Western
NIPBLSP10011255515882967 Reconstituted Complex
NIPBLSP10011736315882967 Reconstituted Complex
SUMO1SP10011318816189514 Two-hybrid
SUMO1SP10011255516189514 Two-hybrid
UBE2ISP10011317718691969 20936779 Biochemical Activity; Reconstituted Complex; Two-hybrid
UBE2ISP10011255518691969 20936779 Biochemical Activity; Reconstituted Complex; Two-hybrid
TRIM29SP10011717720211142 Two-hybrid
TRIM29SP10011255520211142 Two-hybrid
LZTR1SP10011255520211142 Two-hybrid
LZTR1SP10011385220211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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