AutismKB 2.0

Annotation Details for SPARC


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Basic Information Top
Gene Symbol:SPARC ( ON )
Gene Full Name: secreted protein, acidic, cysteine-rich (osteonectin)
Band: 5q33.1
Quick LinksEntrez ID:6678; OMIM: 182120; Uniprot ID:SPRC_HUMAN; ENSEMBL ID: ENSG00000113140; HGNC ID: 11219
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005604IEA-basement membrane-
GO:0005615IBA-extracellular space-
GO:0005737IDA-cytoplasm3400777
GO:0005737IDANOTcytoplasm1737102
GO:0005739IDANOTmitochondrion1737102
GO:0005886IDANOTplasma membrane1737102
GO:0009986IDA-cell surface3400777
GO:0016363IDA-nuclear matrix15389586
GO:0031091IDA-platelet alpha granule1737102
GO:0031092IDA-platelet alpha granule membrane1737102
GO:0031093TAS-platelet alpha granule lumen-
GO:0071682TAS-endocytic vesicle lumen-
GO ID Evidence Qualifier GO_term References
GO:0005509IDA-calcium ion binding7034958
GO:0005515IPI-protein binding3402455
GO:0005518IDA-collagen binding7034958
GO:0050840IBA-extracellular matrix binding-
GO ID Evidence Qualifier GO_term References
GO:0001503IEA-ossification-
GO:0001937IDA-negative regulation of endothelial cell proliferation12867428
GO:0002576TAS-platelet degranulation-
GO:0006898TAS-receptor-mediated endocytosis-
GO:0007165IEA-signal transduction-
GO:0007507IEA-heart development-
GO:0009629IEA-response to gravity-
GO:0010288IEA-response to lead ion-
GO:0010595IDA-positive regulation of endothelial cell migration12867428
GO:0016525IDA-negative regulation of angiogenesis12867428
GO:0022604IDA-regulation of cell morphogenesis15389586
GO:0030198TAS-extracellular matrix organization-
GO:0030324IEA-lung development-
GO:0032496IEA-response to lipopolysaccharide-
GO:0033591IEA-response to L-ascorbic acid-
GO:0034097IEA-response to cytokine-
GO:0042060IEA-wound healing-
GO:0043434IEA-response to peptide hormone-
GO:0043473IEA-pigmentation-
GO:0045471IEA-response to ethanol-
GO:0046686IEA-response to cadmium ion-
GO:0048839IEA-inner ear development-
GO:0051384IEA-response to glucocorticoid-
GO:0051591IEA-response to cAMP-
GO:0051592IEA-response to calcium ion-
GO:0060348IEA-bone development-
GO:0071363IEA-cellular response to growth factor stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPARCCOL1A11125602745554 Reconstituted Complex
SPARCCOL1A11076742745554 Reconstituted Complex
SPARCCOL3A11125602745554 Reconstituted Complex
SPARCCOL3A11076782745554 Reconstituted Complex
SPARCCOL5A11076862745554 Reconstituted Complex
SPARCCOL5A11125602745554 Reconstituted Complex
SPARCPDGFB1125601311092 Reconstituted Complex
SPARCPDGFB1111811311092 Reconstituted Complex
SPARCPLG1113567982919 Reconstituted Complex
SPARCPLG1125607982919 Reconstituted Complex
VEGFASPARC1132659792673 Far Western
VEGFASPARC1125609792673 Far Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98373
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-9'