AutismKB 2.0

Annotation Details for SPAST


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Basic Information Top
Gene Symbol:SPAST ( ADPSP,FSP2,KIAA1083,SPG4 )
Gene Full Name: spastin
Band: 2p22.3
Quick LinksEntrez ID:6683; OMIM: 604277; Uniprot ID:SPAST_HUMAN; ENSEMBL ID: ENSG00000021574; HGNC ID: 11233
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000815TAScolocalizes_withESCRT III complex28242692
GO:0005634IDA-nucleus16026783
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm16026783
GO:0005768IDAcolocalizes_withendosome19000169
GO:0005783IDAcolocalizes_withendoplasmic reticulum19000169
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005811IEA-lipid particle-
GO:0005815IEA-microtubule organizing center-
GO:0005819IEA-spindle-
GO:0005829IDA-cytosol-
GO:0005874IEA-microtubule-
GO:0015630IDAcolocalizes_withmicrotubule cytoskeleton15716377
GO:0030496IDA-midbody21310966
GO:0030496IDAcolocalizes_withmidbody19000169
GO:0030496IMP-midbody18997780
GO:0031410IDA-cytoplasmic vesicle21545838
GO:0031965IMP-nuclear membrane26040712
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO:1904115IEA-axon cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding16815977
GO:0005524IEA-ATP binding-
GO:0008017IDA-microtubule binding15716377
GO:0008568IDA-microtubule-severing ATPase activity15716377
GO:0043014IPI-alpha-tubulin binding17389232
GO:0048487IDA-beta-tubulin binding26875866
GO:0048487IPI-beta-tubulin binding17389232
GO ID Evidence Qualifier GO_term References
GO:0000281IMP-mitotic cytokinesis21310966
GO:0001578IDA-microtubule bundle formation16219033
GO:0006888IMP-ER to Golgi vesicle-mediated transport19000169
GO:0006998TAS-nuclear envelope organization28242692
GO:0007399IEA-nervous system development-
GO:0008089ISS-anterograde axonal transport-
GO:0008152IEA-metabolic process-
GO:0010458IMP-exit from mitosis26040712
GO:0019896ISS-axonal transport of mitochondrion-
GO:0030154IEA-cell differentiation-
GO:0031122IBA-cytoplasmic microtubule organization-
GO:0031468IMP-nuclear envelope reassembly26040712
GO:0032467IMP-positive regulation of cytokinesis18997780
GO:0032506IMP-cytokinetic process19000169
GO:0034214IDA-protein hexamerization17389232
GO:0051013IDA-microtubule severing15716377
GO:0051013IMP-microtubule severing21310966
GO:0051228IMP-mitotic spindle disassembly26040712
GO:0051230TAS-spindle disassembly28242692
GO:0051260IDA-protein homooligomerization17389232
GO:0061640TAS-cytoskeleton-dependent cytokinesis28242692
GO:0090148IMP-membrane fission21310966
Protein-Protein Interaction Top
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1858896
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-2331'