AutismKB 2.0

Annotation Details for SPI1


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Basic Information Top
Gene Symbol:SPI1 ( OF,PU.1,SFPI1,SPI-1,SPI-A )
Gene Full Name: spleen focus forming virus (SFFV) proviral integration oncogene spi1
Band: 11p11.2
Quick LinksEntrez ID:6688; OMIM: 165170; Uniprot ID:SPI1_HUMAN; ENSEMBL ID: ENSG00000066336; HGNC ID: 11241
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin15304486
GO:0005654IDA-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0000979IEA-RNA polymerase II core promoter sequence-specific DNA binding-
GO:0000980ISS-RNA polymerase II distal enhancer sequence-specific DNA binding-
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0001047IDA-core promoter binding20139074
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001078IEA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001085ISS-RNA polymerase II transcription factor binding-
GO:0001205IEA-transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding12833137
GO:0003705ISS-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding-
GO:0003723IEA-RNA binding-
GO:0005515IPI-protein binding10207087
GO:0051525ISS-NFAT protein binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0002320IEA-lymphoid progenitor cell differentiation-
GO:0006357IBA-regulation of transcription from RNA polymerase II promoter-
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0030098IEA-lymphocyte differentiation-
GO:0030218IEA-erythrocyte differentiation-
GO:0030225IEA-macrophage differentiation-
GO:0030851IEA-granulocyte differentiation-
GO:0035019IEA-somatic stem cell population maintenance-
GO:0043011IEA-myeloid dendritic cell differentiation-
GO:0043966IMP-histone H3 acetylation20139074
GO:0044027IDA-hypermethylation of CpG island20139074
GO:0045347IEA-negative regulation of MHC class II biosynthetic process-
GO:0045646IMP-regulation of erythrocyte differentiation12833137
GO:0045814IDA-negative regulation of gene expression, epigenetic20139074
GO:0045892IDA-negative regulation of transcription, DNA-templated20139074
GO:0045893IDA-positive regulation of transcription, DNA-templated12833137
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0060033IEA-anatomical structure regression-
GO:0071361IEA-cellular response to ethanol-
GO:0090241IMP-negative regulation of histone H4 acetylation20139074
GO:1902262IEA-apoptotic process involved in blood vessel morphogenesis-
GO:1902895ISS-positive regulation of pri-miRNA transcription from RNA polymerase II promoter-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPI1ATF11069567730336 Reconstituted Complex
SPI1ATF11125667730336 Reconstituted Complex
SPI1BCL610707619564417 Affinity Capture-Western; Reconstituted Complex
SPI1BCL611256619564417 Affinity Capture-Western; Reconstituted Complex
SPI1CEBPA11256612091339 16983342 Affinity Capture-Western; Reconstituted Complex
SPI1CEBPA10747912091339 16983342 Affinity Capture-Western; Reconstituted Complex
SPI1CEBPB1125667594592 Reconstituted Complex
SPI1CEBPB1074807594592 Reconstituted Complex
SPI1CREM1125667730336 Reconstituted Complex
SPI1CREM1077807730336 Reconstituted Complex
SPI1CSNK2A11078418632909 Biochemical Activity
SPI1CSNK2A11125668632909 Biochemical Activity
SPI1DNMT3A10812516331260 Affinity Capture-Western; Reconstituted Complex
SPI1DNMT3A11256616331260 Affinity Capture-Western; Reconstituted Complex
SPI1DNMT3B10812616331260 Affinity Capture-Western; Reconstituted Complex
SPI1DNMT3B11256616331260 Affinity Capture-Western; Reconstituted Complex
SPI1ETS11084149681824 Reconstituted Complex
SPI1ETS11125669681824 Reconstituted Complex
SPI1ETS21125669681824 Reconstituted Complex
SPI1ETS21084159681824 Reconstituted Complex
SPI1ETV11125669681824 Reconstituted Complex
SPI1ETV11084169681824 Reconstituted Complex
SPI1FOS1086369681824 Reconstituted Complex
SPI1FOS1125669681824 Reconstituted Complex
SPI1FUS1087979478924 Affinity Capture-Western; Co-purification; Reconstituted Complex
SPI1FUS1125669478924 Affinity Capture-Western; Co-purification; Reconstituted Complex
SPI1GATA210889410411939 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPI1GATA211256610411939 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPI1HDAC110931511593411 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1HDAC111256611593411 14647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1IRF410987010022840 12372320 Co-crystal Structure; Reconstituted Complex
SPI1IRF411256610022840 12372320 Co-crystal Structure; Reconstituted Complex
SPI1JUN1099289681824 Reconstituted Complex
SPI1JUN1125669681824 Reconstituted Complex
SPI1MECP211036814647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1MECP211256614647463 16331260 Affinity Capture-Western; Reconstituted Complex
SPI1MITF1104329918847 Reconstituted Complex
SPI1MITF1125669918847 Reconstituted Complex
SPI1NFYA1108669668064 Reconstituted Complex
SPI1NFYA1125669668064 Reconstituted Complex
SPI1NONO1109048626664 Affinity Capture-Western; Reconstituted Complex
SPI1NONO1125668626664 Affinity Capture-Western; Reconstituted Complex
SPI1MAPK81115858632909 Biochemical Activity
SPI1MAPK81125668632909 Biochemical Activity
SPI1SKI11238817621263 Affinity Capture-Western; Reconstituted Complex
SPI1SKI11256617621263 Affinity Capture-Western; Reconstituted Complex
SPIBSPI111256710196196 Reconstituted Complex
SPIBSPI111256610196196 Reconstituted Complex
TBPSPI111277111593411 Affinity Capture-Western
TBPSPI111256611593411 Affinity Capture-Western
SIN3ASPI111743911593411 Affinity Capture-Western; Reconstituted Complex
SIN3ASPI111256611593411 Affinity Capture-Western; Reconstituted Complex
HDAC3SPI111436817621263 Affinity Capture-Western
HDAC3SPI111256617621263 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98282
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-980526-164'