AutismKB 2.0

Annotation Details for SPTBN1


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Basic Information Top
Gene Symbol:SPTBN1 ( ELF,SPTB2,betaSpII )
Gene Full Name: spectrin, beta, non-erythrocytic 1
Band: 2p16.2
Quick LinksEntrez ID:6711; OMIM: 182790; Uniprot ID:SPTB2_HUMAN; ENSEMBL ID: ENSG00000115306; HGNC ID: 11275
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005730IDA-nucleolus9537418
GO:0005737IDA-cytoplasm9537418
GO:0005829TAS-cytosol-
GO:0008091IEA-spectrin-
GO:0014069IEA-postsynaptic density-
GO:0014731NAS-spectrin-associated cytoskeleton17620337
GO:0030673ISS-axolemma-
GO:0031430IEA-M band-
GO:0032437IEA-cuticular plate-
GO:0043234IEA-protein complex-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22681889
GO:0003779IEA-actin binding-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005200IMP-structural constituent of cytoskeleton17620337
GO:0005515IPI-protein binding9537418
GO:0005516IEA-calmodulin binding-
GO:0005543IEA-phospholipid binding-
GO:0030506IPI-ankyrin binding15262991
GO:0030506NAS-ankyrin binding17620337
GO:0032403IEA-protein complex binding-
GO:0045296IDA-cadherin binding25468996
GO:0051020IPI-GTPase binding24337748
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000281IMP-mitotic cytokinesis17620337
GO:0006888TAS-ER to Golgi vesicle-mediated transport-
GO:0007009IMP-plasma membrane organization17620337
GO:0007010IEA-cytoskeleton organization-
GO:0007182IEA-common-partner SMAD protein phosphorylation-
GO:0007184IEA-SMAD protein import into nucleus-
GO:0007411TAS-axon guidance-
GO:0043001IMP-Golgi to plasma membrane protein transport17620337
GO:0043547IEA-positive regulation of GTPase activity-
GO:0051693IEA-actin filament capping-
GO:0071709IMP-membrane assembly17620337
GO:0072661IMP-protein targeting to plasma membrane17620337
GO:1900042IMP-positive regulation of interleukin-2 secretion24337748
GO:1903076IGI-regulation of protein localization to plasma membrane24337748
GO:1903078IMP-positive regulation of protein localization to plasma membrane24337748
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SPTBN1APC10682120936779 Two-hybrid
SPTBN1APC11258920936779 Two-hybrid
SPTBN1CEBPA11258917082780 Affinity Capture-MS
SPTBN1CEBPA10747917082780 Affinity Capture-MS
SPTBN1MAPK1410781920936779 Two-hybrid
SPTBN1MAPK1411258920936779 Two-hybrid
SPTBN1CTNNA110787611069925 Reconstituted Complex
SPTBN1CTNNA111258911069925 Reconstituted Complex
SPTBN1DCTN11080078991093 Affinity Capture-Western
SPTBN1DCTN11125898991093 Affinity Capture-Western
SPTBN1GRB210914220936779 Two-hybrid
SPTBN1GRB211258920936779 Two-hybrid
SPTBN1GRIA211258910576550 Far Western
SPTBN1GRIA210914810576550 Far Western
SPTBN1MEF2C11037220936779 Two-hybrid
SPTBN1MEF2C11258920936779 Two-hybrid
SPTBN1NF211258911535133 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPTBN1NF211084411535133 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SPTBN1SNCA11250618614564 Affinity Capture-Western
SPTBN1SNCA11258918614564 Affinity Capture-Western
EPB41L3SPTBN111675315116094 Reconstituted Complex
EPB41L3SPTBN111258915116094 Reconstituted Complex
SRRM2SPTBN111707116159877 Affinity Capture-MS
SRRM2SPTBN111258916159877 Affinity Capture-MS
UBCSPTBN111316416247473 Affinity Capture-Western
UBCSPTBN111258916247473 Affinity Capture-Western
PJA1SPTBN112210916247473 Affinity Capture-Western; Reconstituted Complex
PJA1SPTBN111258916247473 Affinity Capture-Western; Reconstituted Complex
PLCB1SPTBN111684120936779 Two-hybrid
PLCB1SPTBN111258920936779 Two-hybrid
PYGO1SPTBN111258920936779 Two-hybrid
PYGO1SPTBN111755720936779 Two-hybrid
PACSIN1SPTBN111258920936779 Two-hybrid
PACSIN1SPTBN111901820936779 Two-hybrid
PLEKHA5SPTBN111258920936779 Two-hybrid
PLEKHA5SPTBN111998220936779 Two-hybrid
SREBF2SPTBN111259920936779 Two-hybrid
SREBF2SPTBN111258920936779 Two-hybrid
STAT1SPTBN111264920936779 Two-hybrid
STAT1SPTBN111258920936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
EPB41L3SPTBN121773215688033 EPB41L3 (DAL-1) interacts with an unspecified isoform of SPTBN1 (beta-II-spectrin).
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98388
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-031006-3'