AutismKB 2.0

Annotation Details for BRCA1


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Basic Information Top
Gene Symbol:BRCA1 ( BRCAI,BRCC1,BROVCA1,IRIS,PNCA4,PSCP,RNF53 )
Gene Full Name: breast cancer 1, early onset
Band: 17q21.31
Quick LinksEntrez ID:672; OMIM: 113705; Uniprot ID:BRCA1_HUMAN; ENSEMBL ID: ENSG00000012048; HGNC ID: 1100
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000151NAS-ubiquitin ligase complex14976165
GO:0000800IDA-lateral element9774970
GO:0005634IDA-nucleus17525340
GO:0005654TAS-nucleoplasm-
GO:0005694ISS-chromosome-
GO:0005737IDA-cytoplasm20160719
GO:0005886IDA-plasma membrane21282464
GO:0008274NAS-gamma-tubulin ring complex12214252
GO:0030529IDA-intracellular ribonucleoprotein complex18809582
GO:0031436IDA-BRCA1-BARD1 complex12890688
GO:0043234IDA-protein complex9774970
GO:0070531IDA-BRCA1-A complex17525340
GO ID Evidence Qualifier GO_term References
GO:0003677TAS-DNA binding9662397
GO:0003684IEA-damaged DNA binding-
GO:0003713NAS-transcription coactivator activity15572661
GO:0003723IDA-RNA binding12419249
GO:0004842IDA-ubiquitin-protein transferase activity12890688
GO:0005515IPI-protein binding8944023
GO:0008270IEA-zinc ion binding-
GO:0015631NAS-tubulin binding12214252
GO:0019899IPI-enzyme binding15965487
GO:0031625IPI-ubiquitin protein ligase binding17873885
GO:0044212IDA-transcription regulatory region DNA binding20820192
GO:0050681NAS-androgen receptor binding15572661
GO ID Evidence Qualifier GO_term References
GO:0000724IDA-double-strand break repair via homologous recombination17349954
GO:0000729TAS-DNA double-strand break processing-
GO:0000731TAS-DNA synthesis involved in DNA repair-
GO:0000732TAS-strand displacement-
GO:0006260TAS-DNA replication-
GO:0006301IDA-postreplication repair17349954
GO:0006302IDA-double-strand break repair22186889
GO:0006302IMP-double-strand break repair17525340
GO:0006303TAS-double-strand break repair via nonhomologous end joining-
GO:0006349IEA-regulation of gene expression by genetic imprinting-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter10910365
GO:0006359TAS-regulation of transcription from RNA polymerase III promoter10918303
GO:0006633IEA-fatty acid biosynthetic process-
GO:0006915TAS-apoptotic process10918303
GO:0006974TAS-cellular response to DNA damage stimulus10910365
GO:0006978TAS-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator10918303
GO:0007059IMP-chromosome segregation15965487
GO:0007098IEA-centrosome cycle-
GO:0008630IDA-intrinsic apoptotic signaling pathway in response to DNA damage14654789
GO:0009048IBA-dosage compensation by inactivation of X chromosome-
GO:0010212IMP-response to ionizing radiation17525340
GO:0010575IMP-positive regulation of vascular endothelial growth factor production23415688
GO:0010628IMP-positive regulation of gene expression23415688
GO:0016567IDA-protein ubiquitination17349954
GO:0016579TAS-protein deubiquitination-
GO:0030521NAS-androgen receptor signaling pathway15572661
GO:0031398IDA-positive regulation of protein ubiquitination15965487
GO:0031572IMP-G2 DNA damage checkpoint17525340
GO:0033147IMP-negative regulation of intracellular estrogen receptor signaling pathway17505062
GO:0035066IDA-positive regulation of histone acetylation20820192
GO:0035067IBA-negative regulation of histone acetylation-
GO:0042127TAS-regulation of cell proliferation10918303
GO:0042981TAS-regulation of apoptotic process10918303
GO:0043009IBA-chordate embryonic development-
GO:0043627IDA-response to estrogen8895509
GO:0044030IEA-regulation of DNA methylation-
GO:0044818IEA-mitotic G2/M transition checkpoint-
GO:0045717IMP-negative regulation of fatty acid biosynthetic process16326698
GO:0045739IMP-positive regulation of DNA repair17525340
GO:0045766IMP-positive regulation of angiogenesis23415688
GO:0045892IDA-negative regulation of transcription, DNA-templated16288014
GO:0045893IDA-positive regulation of transcription, DNA-templated20160719
GO:0045893NAS-positive regulation of transcription, DNA-templated15572661
GO:0045893TAS-positive regulation of transcription, DNA-templated10918303
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16331276
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter20820192
GO:0046600NAS-negative regulation of centriole replication12214252
GO:0051571IDA-positive regulation of histone H3-K4 methylation20820192
GO:0051572IEA-negative regulation of histone H3-K4 methylation-
GO:0051573IDA-negative regulation of histone H3-K9 methylation20820192
GO:0051574IEA-positive regulation of histone H3-K9 methylation-
GO:0051865IDA-protein autoubiquitination12890688
GO:0070512IDA-positive regulation of histone H4-K20 methylation20820192
GO:0071158IDA-positive regulation of cell cycle arrest21102443
GO:0071356IMP-cellular response to tumor necrosis factor23415688
GO:0071681IDA-cellular response to indole-3-methanol10868478
GO:0085020IDA-protein K6-linked ubiquitination12890688
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1902042IMP-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors23415688
GO:2000378IMP-negative regulation of reactive oxygen species metabolic process23415688
GO:2000617IDA-positive regulation of histone H3-K9 acetylation20820192
GO:2000620IDA-positive regulation of histone H4-K16 acetylation20820192
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BRCA1ABL110654312024016 Affinity Capture-Western
BRCA1ABL110714012024016 Affinity Capture-Western
BRCA1ACACA10654912360400 16326698 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BRCA1ACACA10714012360400 16326698 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BRCA1AKT110671010542266 19074868 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BRCA1AKT110714010542266 19074868 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BRCA1APLP210683111746496 Far Western
BRCA1APLP210714011746496 Far Western
BRCA1AR10714011016951 11085509 Reconstituted Complex; Two-hybrid
BRCA1AR10686211016951 11085509 Reconstituted Complex; Two-hybrid
BRCA1ARNT10689816567799 Affinity Capture-Western; Reconstituted Complex
BRCA1ARNT10714016567799 Affinity Capture-Western; Reconstituted Complex
BRCA1ATF110695610945975 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BRCA1ATF110714010945975 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BRCA1ATM10714010550055 10608806 10783165 10866324 11016625 11114888 11278964 17478428 18344987 Affinity Capture-Western; Co-purification; Protein-peptide; Reconstituted Complex
BRCA1ATM10696210550055 10608806 10783165 10866324 11016625 11114888 11278964 17478428 18344987 Affinity Capture-Western; Co-purification; Protein-peptide; Reconstituted Complex
BRCA1ATR10702710608806 11016625 11114888 11278964 17478428 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
BRCA1ATR10714010608806 11016625 11114888 11278964 17478428 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
BRCA1BACH110714011301010 17664283 Affinity Capture-Western; Reconstituted Complex
BRCA1BARD11070568944023 9342365 9738006 9788437 10026184 10477523 10635334 11257228 11278247 11301010 11498787 11504724 11526114 11573085 11773071 11925436 11927591 12431996 12438698 12485996 12700228 12732733 12890688 12951069 14636569 14638690 14647430 15159397 16489000 17525341 17664283 18936166 19117993 19176389 20215511 Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; FRET; Reconstituted Complex; Two-hybrid
BRCA1BARD11071408944023 9342365 9738006 9788437 10026184 10477523 10635334 11257228 11278247 11301010 11498787 11504724 11526114 11573085 11773071 11925436 11927591 12431996 12438698 12485996 12700228 12732733 12890688 12951069 14636569 14638690 14647430 15159397 16489000 17525341 17664283 18936166 19117993 19176389 20215511 Affinity Capture-Western; Co-crystal Structure; Co-localization; Co-purification; FRET; Reconstituted Complex; Two-hybrid
BRCA1CCND11070679244350 Reconstituted Complex
BRCA1CCND11071409244350 Reconstituted Complex
BRCA1BLM10711010783165 Co-purification
BRCA1BLM10714010783165 Co-purification
CDK2BRCA11074528764100 9244350 10373534 Affinity Capture-Western; Reconstituted Complex
CDK2BRCA11071408764100 9244350 10373534 Affinity Capture-Western; Reconstituted Complex
BRAPBRCA11071408955125 9497340 Reconstituted Complex; Two-hybrid
BRAPBRCA11139128955125 9497340 Reconstituted Complex; Two-hybrid
KPNA2BRCA11071408955125 Two-hybrid
KPNA2BRCA11100368955125 Two-hybrid
RAD51BRCA11071409008167 9774970 11498787 14636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
RAD51BRCA11118259008167 9774970 11498787 14636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
POLR2ABRCA11071409159119 11504724 12955082 14506230 15886201 Affinity Capture-Western; Biochemical Activity; Co-purification
POLR2ABRCA11114269159119 11504724 12955082 14506230 15886201 Affinity Capture-Western; Biochemical Activity; Co-purification
MED21BRCA11071409159119 Affinity Capture-Western; Co-purification
MED21BRCA11148079159119 Affinity Capture-Western; Co-purification
CDK8BRCA11074589159119 Co-purification
CDK8BRCA11071409159119 Co-purification
GTF2E1BRCA11071409159119 Co-purification
GTF2E1BRCA11092159159119 Co-purification
GTF2F1BRCA11092179159119 Co-purification
GTF2F1BRCA11071409159119 Co-purification
GTF2H4BRCA11071409159119 Co-purification
GTF2H4BRCA11092239159119 Co-purification
CDK4BRCA11074549244350 Reconstituted Complex
CDK4BRCA11071409244350 Reconstituted Complex
CDK5BRCA11074559244350 Reconstituted Complex
CDK5BRCA11071409244350 Reconstituted Complex
E2F4BRCA11082069244350 Reconstituted Complex
E2F4BRCA11071409244350 Reconstituted Complex
CCNA1BRCA11144179244350 Reconstituted Complex
CCNA1BRCA11071409244350 Reconstituted Complex
CCNB1BRCA11073329244350 Reconstituted Complex
CCNB1BRCA11071409244350 Reconstituted Complex
CDK1BRCA11071409244350 Reconstituted Complex
CDK1BRCA11074209244350 Reconstituted Complex
CREBBPBRCA11071409443979 9926942 10655477 11782371 12700228 16860316 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
CREBBPBRCA11077779443979 9926942 10655477 11782371 12700228 16860316 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
TP53BRCA11130109482880 9582019 9926942 14636569 14710355 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
TP53BRCA11071409482880 9582019 9926942 14636569 14710355 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex
BRCA1BRCA11071409525870 11573086 14578343 16818604 Biochemical Activity; Co-crystal Structure; Protein-peptide; Reconstituted Complex
DHX9BRCA11080259662397 12592385 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DHX9BRCA11071409662397 12592385 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RBBP8BRCA11071409738006 9811458 10196224 10764811 10910365 11689934 14578343 16818604 17525342 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Protein-peptide; Reconstituted Complex; Two-hybrid
RBBP8BRCA11118679738006 9811458 10196224 10764811 10910365 11689934 14578343 16818604 17525342 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Co-localization; Protein-peptide; Reconstituted Complex; Two-hybrid
HSPA8BRCA11071409738006 Two-hybrid
HSPA8BRCA11095449738006 Two-hybrid
CDK16BRCA11111549738006 Two-hybrid
CDK16BRCA11071409738006 Two-hybrid
BRCA2BRCA11071429774970 11477095 14499622 14636569 17664283 21135251 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
BRCA2BRCA11071409774970 11477095 14499622 14636569 17664283 21135251 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
MYCBRCA11106949788437 11916966 12646176 14612409 20215511 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
MYCBRCA11071409788437 11916966 12646176 14612409 20215511 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
TUBG1BRCA11131349789027 11691781 15367667 Affinity Capture-Western; Biochemical Activity; Co-localization; Co-purification; Reconstituted Complex
TUBG1BRCA11071409789027 11691781 15367667 Affinity Capture-Western; Biochemical Activity; Co-localization; Co-purification; Reconstituted Complex
CTBP1BRCA110786910196224 Affinity Capture-Western
CTBP1BRCA110714010196224 Affinity Capture-Western
RB1BRCA110714010220405 10518542 11521194 Affinity Capture-Western; Co-localization; Reconstituted Complex
RB1BRCA111186010220405 10518542 11521194 Affinity Capture-Western; Co-localization; Reconstituted Complex
RBBP7BRCA110714010220405 11394910 11746496 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
RBBP7BRCA111186610220405 11394910 11746496 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
RBBP4BRCA110714010220405 Affinity Capture-Western; Reconstituted Complex
RBBP4BRCA111186310220405 Affinity Capture-Western; Reconstituted Complex
HDAC1BRCA110714010220405 Reconstituted Complex
HDAC1BRCA110931510220405 Reconstituted Complex
HDAC2BRCA110714010220405 Reconstituted Complex
HDAC2BRCA110931610220405 Reconstituted Complex
CCNA2BRCA110733110373534 Affinity Capture-Western
CCNA2BRCA110714010373534 Affinity Capture-Western
CSNK2A1BRCA110784110403822 Reconstituted Complex
CSNK2A1BRCA110714010403822 Reconstituted Complex
CSNK2BBRCA110784310403822 Reconstituted Complex; Two-hybrid
CSNK2BBRCA110714010403822 Reconstituted Complex; Two-hybrid
MRE11ABRCA110714010426999 10783165 11353843 11504724 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
MRE11ABRCA111050110426999 10783165 11353843 11504724 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
RAD50BRCA110714010426999 10783165 11504724 16260778 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
RAD50BRCA111541710426999 10783165 11504724 16260778 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
NBNBRCA110714010426999 10783165 11504724 Co-localization; Co-purification
NBNBRCA111076310426999 10783165 11504724 Co-localization; Co-purification
CSTF2BRCA110714010477523 11257228 Affinity Capture-Western; Co-purification
CSTF2BRCA110786010477523 11257228 Affinity Capture-Western; Co-purification
PRKDCBRCA110714010608806 Protein-peptide
PRKDCBRCA111157710608806 Protein-peptide
EP300BRCA110834710655477 11782371 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
EP300BRCA110714010655477 11782371 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
CHEK2BRCA110714010724175 18804494 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
CHEK2BRCA111636910724175 18804494 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MLH1BRCA110714010783165 17148452 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-purification
MLH1BRCA111043810783165 17148452 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-purification
MSH2BRCA111057310783165 11498787 15886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
MSH2BRCA110714010783165 11498787 15886699 16260778 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
MSH6BRCA110921110783165 11498787 16260778 Affinity Capture-MS; Co-purification; Reconstituted Complex; Two-hybrid
MSH6BRCA110714010783165 11498787 16260778 Affinity Capture-MS; Co-purification; Reconstituted Complex; Two-hybrid
RFC1BRCA110714010783165 Co-purification
RFC1BRCA111191310783165 Co-purification
STAT1BRCA110714010792030 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT1BRCA111264910792030 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VCPBRCA111325810855792 Affinity Capture-Western; Reconstituted Complex
VCPBRCA110714010855792 Affinity Capture-Western; Reconstituted Complex
SMARCA4BRCA111248110943845 15034933 Affinity Capture-Western; Co-purification; Reconstituted Complex
SMARCA4BRCA110714010943845 15034933 Affinity Capture-Western; Co-purification; Reconstituted Complex
SMARCB1BRCA110714010943845 Co-purification
SMARCB1BRCA111248210943845 Co-purification
SMARCC1BRCA110714010943845 Co-purification
SMARCC1BRCA111248310943845 Co-purification
SMARCC2BRCA110714010943845 Co-purification
SMARCC2BRCA111248510943845 Co-purification
SMARCD2BRCA110714010943845 Co-purification
SMARCD2BRCA111248710943845 Co-purification
CREB1BRCA110777510945975 Phenotypic Enhancement
CREB1BRCA110714010945975 Phenotypic Enhancement
H2AFXBRCA110714010959836 11927591 12485996 18344987 19805520 Affinity Capture-Western; Co-localization; Reconstituted Complex
H2AFXBRCA110926810959836 11927591 12485996 18344987 19805520 Affinity Capture-Western; Co-localization; Reconstituted Complex
NCOA2BRCA110714011085509 14578343 16860316 Protein-peptide; Reconstituted Complex
NCOA2BRCA111576111085509 14578343 16860316 Protein-peptide; Reconstituted Complex
ZNF350BRCA112188911090615 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZNF350BRCA110714011090615 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JAK1BRCA110714011163768 Affinity Capture-Western
JAK1BRCA110991911163768 Affinity Capture-Western
JAK2BRCA110714011163768 Affinity Capture-Western
JAK2BRCA110992011163768 Affinity Capture-Western
ESR1BRCA110714011244506 11493692 11782371 12400015 16061635 16260778 16860316 Affinity Capture-Western; Co-localization; Reconstituted Complex
ESR1BRCA110840311244506 11493692 11782371 12400015 16061635 16260778 16860316 Affinity Capture-Western; Co-localization; Reconstituted Complex
CSTF1BRCA110714011257228 Reconstituted Complex
CSTF1BRCA110785911257228 Reconstituted Complex
UBA1BRCA111316511278247 11927591 12438698 12485996 14638690 Reconstituted Complex
UBA1BRCA110714011278247 11927591 12438698 12485996 14638690 Reconstituted Complex
UBE2D1BRCA110714011278247 11927591 12438698 12485996 12732733 12890688 14636569 14638690 Reconstituted Complex
UBE2D1BRCA111316911278247 11927591 12438698 12485996 12732733 12890688 14636569 14638690 Reconstituted Complex
ELK4BRCA110832011313879 Affinity Capture-Western; Reconstituted Complex
ELK4BRCA110714011313879 Affinity Capture-Western; Reconstituted Complex
ETS1BRCA110714011313879 Reconstituted Complex
ETS1BRCA110841411313879 Reconstituted Complex
FLI1BRCA110714011313879 Reconstituted Complex
FLI1BRCA110860211313879 Reconstituted Complex
MSH3BRCA110714011498787 14578343 Protein-peptide; Reconstituted Complex
MSH3BRCA111057411498787 14578343 Protein-peptide; Reconstituted Complex
MED17BRCA110714011504724 12154023 15208681 Affinity Capture-MS; Co-purification
MED17BRCA111483011504724 12154023 15208681 Affinity Capture-MS; Co-purification
RBL1BRCA110714011521194 Co-localization; Reconstituted Complex
RBL1BRCA111186811521194 Co-localization; Reconstituted Complex
RBL2BRCA110714011521194 Co-localization; Reconstituted Complex
RBL2BRCA111186911521194 Co-localization; Reconstituted Complex
COBRA1BRCA111742111739404 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
COBRA1BRCA110714011739404 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PEG3BRCA111120411746496 Far Western
PEG3BRCA110714011746496 Far Western
WNT2BBRCA111331911746496 Far Western
WNT2BBRCA110714011746496 Far Western
RPL31BRCA110714011746496 Far Western; Reconstituted Complex
RPL31BRCA111207911746496 Far Western; Reconstituted Complex
LMO4BRCA111411311751867 12925972 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
LMO4BRCA110714011751867 12925972 Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
NFYABRCA110714011777930 Affinity Capture-Western
NFYABRCA111086611777930 Affinity Capture-Western
POU2F1BRCA111144711777930 18000219 Affinity Capture-Western
POU2F1BRCA110714011777930 18000219 Affinity Capture-Western
BRIP1BRCA112384111877378 14576433 14578343 15133502 15208681 15242590 17525341 17525342 20173781 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex
BRIP1BRCA110714011877378 14576433 14578343 15133502 15208681 15242590 17525341 17525342 20173781 21240188 Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Protein-peptide; Reconstituted Complex
NMIBRCA111456111916966 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NMIBRCA110714011916966 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIST2H2ACBRCA110714011927591 Reconstituted Complex
HIST2H2ACBRCA111393411927591 Reconstituted Complex
JUNBRCA110992812080089 Affinity Capture-Western; Reconstituted Complex
JUNBRCA110714012080089 Affinity Capture-Western; Reconstituted Complex
JUNBBRCA110714012080089 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNBBRCA110992912080089 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNDBRCA110714012080089 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNDBRCA110993012080089 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FANCABRCA110847212354784 21240188 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FANCABRCA110714012354784 21240188 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TP53BP1BRCA111301112364621 17525332 Affinity Capture-Western
TP53BP1BRCA110714012364621 17525332 Affinity Capture-Western
HIST2H3CBRCA112602512419249 Co-localization
HIST2H3CBRCA110714012419249 Co-localization
XISTBRCA111334012419249 15065664 Co-localization
XISTBRCA110714012419249 15065664 Co-localization
H2AFYBRCA111492712419249 Co-localization
H2AFYBRCA110714012419249 Co-localization
PPP1CABRCA110714012438214 17511879 Affinity Capture-Western; Reconstituted Complex
PPP1CABRCA111149312438214 17511879 Affinity Capture-Western; Reconstituted Complex
CDS1BRCA110714012438214 Reconstituted Complex
CDS1BRCA110747112438214 Reconstituted Complex
STAT5ABRCA111265312459499 Affinity Capture-Western
STAT5ABRCA110714012459499 Affinity Capture-Western
RELABRCA111190212700228 Affinity Capture-Western; Reconstituted Complex
RELABRCA110714012700228 Affinity Capture-Western; Reconstituted Complex
SP1BRCA111255012706836 Affinity Capture-Western
SP1BRCA110714012706836 Affinity Capture-Western
UBE2L3BRCA111318012732733 Reconstituted Complex
UBE2L3BRCA110714012732733 Reconstituted Complex
FANCD2BRCA110714012887909 14499622 Biochemical Activity; Two-hybrid
FANCD2BRCA110847412887909 14499622 Biochemical Activity; Two-hybrid
UBE3ABRCA111318512890688 Reconstituted Complex
UBE3ABRCA110714012890688 Reconstituted Complex
USF2BRCA111323814502648 Affinity Capture-Western
USF2BRCA110714014502648 Affinity Capture-Western
FHL2BRCA110856514550570 14986435 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FHL2BRCA110714014550570 14986435 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCOA3BRCA111384114578343 16860316 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
NCOA3BRCA110714014578343 16860316 Affinity Capture-Western; Protein-peptide; Reconstituted Complex
CTCFLBRCA112665314578343 Protein-peptide
CTCFLBRCA110714014578343 Protein-peptide
KIF1BBRCA111672314578343 Protein-peptide
KIF1BBRCA110714014578343 Protein-peptide
DNAJA3BRCA110714014578343 Protein-peptide
DNAJA3BRCA111454714578343 Protein-peptide
MAP4K4BRCA111483814578343 Protein-peptide
MAP4K4BRCA110714014578343 Protein-peptide
NUP153BRCA111529714578343 Protein-peptide
NUP153BRCA110714014578343 Protein-peptide
BRCC3BRCA110714014636569 17664283 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BRCC3BRCA112259914636569 17664283 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BREBRCA110714014636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BREBRCA111494614636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
AURKABRCA111266614990569 Affinity Capture-Western; Reconstituted Complex
AURKABRCA110714014990569 Affinity Capture-Western; Reconstituted Complex
SMARCA2BRCA110714015034933 Affinity Capture-Western
SMARCA2BRCA111247915034933 Affinity Capture-Western
CLSPNBRCA110714015096610 Affinity Capture-Western
CLSPNBRCA112201515096610 Affinity Capture-Western
NUFIP1BRCA111780715107825 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NUFIP1BRCA110714015107825 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NPM1BRCA110714015184379 Affinity Capture-Western
NPM1BRCA111092915184379 Affinity Capture-Western
MAP3K3BRCA111037915205325 Affinity Capture-Western; Two-hybrid
MAP3K3BRCA110714015205325 Affinity Capture-Western; Two-hybrid
MED23BRCA110714015208681 Affinity Capture-MS
MED23BRCA111482915208681 Affinity Capture-MS
MED13BRCA111529415208681 Affinity Capture-MS
MED13BRCA110714015208681 Affinity Capture-MS
MED24BRCA111519615208681 Affinity Capture-MS; Affinity Capture-Western
MED24BRCA110714015208681 Affinity Capture-MS; Affinity Capture-Western
MED1BRCA110714015208681 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
MED1BRCA111146515208681 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
UBCBRCA111316415665273 17185394 17525341 Affinity Capture-Western; Reconstituted Complex
UBCBRCA110714015665273 17185394 17525341 Affinity Capture-Western; Reconstituted Complex
SMAD3BRCA110714015735739 Affinity Capture-Western; Reconstituted Complex
SMAD3BRCA111026315735739 Affinity Capture-Western; Reconstituted Complex
TOP2ABRCA111300615965487 Affinity Capture-Western; Reconstituted Complex
TOP2ABRCA110714015965487 Affinity Capture-Western; Reconstituted Complex
TRRAPBRCA111390016260778 Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex
TRRAPBRCA110714016260778 Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex
KAT2ABRCA110714016260778 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
KAT2ABRCA110891816260778 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
SRCBRCA111259216860316 Affinity Capture-Western; Reconstituted Complex
SRCBRCA110714016860316 Affinity Capture-Western; Reconstituted Complex
PPP1R3ABRCA110714017511879 Affinity Capture-Western
PPP1R3ABRCA111149917511879 Affinity Capture-Western
PPP1CBBRCA110714017511879 Affinity Capture-Western; Reconstituted Complex
PPP1CBBRCA111149417511879 Affinity Capture-Western; Reconstituted Complex
ORC3BRCA111713017525332 Affinity Capture-Western
ORC3BRCA110714017525332 Affinity Capture-Western
ORC2BRCA110714017525332 Affinity Capture-Western
ORC2BRCA111104117525332 Affinity Capture-Western
ZCCHC8BRCA110714017525332 Affinity Capture-Western
ZCCHC8BRCA112073917525332 Affinity Capture-Western
CCNE1BRCA110733817525332 Affinity Capture-Western
CCNE1BRCA110714017525332 Affinity Capture-Western
MDC1BRCA110714017525332 Affinity Capture-Western
MDC1BRCA111501417525332 Affinity Capture-Western
UIMC1BRCA111969717525341 17525342 19615732 Affinity Capture-MS; Affinity Capture-Western
UIMC1BRCA110714017525341 17525342 19615732 Affinity Capture-MS; Affinity Capture-Western
SUMO1BRCA111318818025037 20016594 Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid
SUMO1BRCA110714018025037 20016594 Affinity Capture-Western; FRET; Reconstituted Complex; Two-hybrid
FOXO3BRCA110714018344987 Affinity Capture-Western
FOXO3BRCA110859818344987 Affinity Capture-Western
XRCC5BRCA111335318936166 Affinity Capture-Western; Reconstituted Complex
XRCC5BRCA110714018936166 Affinity Capture-Western; Reconstituted Complex
WDR48BRCA112164919615732 Affinity Capture-MS
WDR48BRCA110714019615732 Affinity Capture-MS
UBE2J1BRCA111955519690564 Two-hybrid
UBE2J1BRCA110714019690564 Two-hybrid
TERF1BRCA110714019797051 Affinity Capture-Western
TERF1BRCA111287219797051 Affinity Capture-Western
TERF2BRCA110714019797051 Affinity Capture-Western
TERF2BRCA111287319797051 Affinity Capture-Western
SUMO2BRCA110714020016594 Affinity Capture-Western
SUMO2BRCA111249720016594 Affinity Capture-Western
PIAS4BRCA110714020016594 20016603 Biochemical Activity; Co-localization
PIAS4BRCA111962420016594 20016603 Biochemical Activity; Co-localization
PIAS1BRCA110714020016594 20016603 Biochemical Activity; Co-localization
PIAS1BRCA111412420016594 20016603 Biochemical Activity; Co-localization
UBE2IBRCA111317720016594 Biochemical Activity; FRET
UBE2IBRCA110714020016594 Biochemical Activity; FRET
BRD7BRCA111888320215511 Affinity Capture-Western; Co-localization; Two-hybrid
BRD7BRCA110714020215511 Affinity Capture-Western; Co-localization; Two-hybrid
RPA1BRCA110714021240188 Affinity Capture-Western
RPA1BRCA111203721240188 Affinity Capture-Western
Gene Symbol Interactant Interaction ID References Description
TOP2ABRCA129556915965487 TOP2A (Topo II) interacts with BRCA1
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:104537
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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