AutismKB 2.0

Annotation Details for SREBF2


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Basic Information Top
Gene Symbol:SREBF2 ( SREBP2,bHLHd2 )
Gene Full Name: sterol regulatory element binding transcription factor 2
Band: 22q13.2
Quick LinksEntrez ID:6721; OMIM: 600481; Uniprot ID:SRBP2_HUMAN; ENSEMBL ID: ENSG00000198911; HGNC ID: 11290
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0005634IDA-nucleus12202038
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm12941800
GO:0005739IDA-mitochondrion-
GO:0005783IDA-endoplasmic reticulum12202038
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005829TAS-cytosol-
GO:0012507IEA-ER to Golgi transport vesicle membrane-
GO:0032937IDA-SREBP-SCAP-Insig complex12242332
GO:0043231IDA-intracellular membrane-bounded organelle-
GO ID Evidence Qualifier GO_term References
GO:0000247IDANOTC-8 sterol isomerase activity12941800
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding15358760
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding15358760
GO:0005515IPI-protein binding10976766
GO:0008022IPI-protein C-terminus binding9242699
GO:0046983IEA-protein dimerization activity-
GO:0070888IDA-E-box binding15358760
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15358760
GO:0006351IEA-transcription, DNA-templated-
GO:0006629TAS-lipid metabolic process7903453
GO:0008203IEA-cholesterol metabolic process-
GO:0009267IMP-cellular response to starvation25339898
GO:0010886IDA-positive regulation of cholesterol storage15358760
GO:0045540TAS-regulation of cholesterol biosynthetic process-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter12242332
GO:0055098IEP-response to low-density lipoprotein particle15358760
GO:0071499NAS-cellular response to laminar fluid shear stress15358760
GO:0072368IDA-regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter15358760
GO:0090370IDA-negative regulation of cholesterol efflux15358760
GO:1903146IMP-regulation of mitophagy24912190
GO:1903955IMP-positive regulation of protein targeting to mitochondrion24912190
GO:2000188IEA-regulation of cholesterol homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SREBF2ARRB111259920936779 Two-hybrid
SREBF2ARRB110690120936779 Two-hybrid
SREBF2CASP31125998605870 Biochemical Activity
SREBF2CASP31072868605870 Biochemical Activity
SREBF2CREB111259920936779 Two-hybrid
SREBF2CREB110777520936779 Two-hybrid
SREBF2CREBBP1125998918891 Affinity Capture-Western; Far Western
SREBF2CREBBP1077778918891 Affinity Capture-Western; Far Western
SREBF2EGR111259920936779 Two-hybrid
SREBF2EGR110827820936779 Two-hybrid
SREBF2EP3001125998918891 Far Western
SREBF2EP3001083478918891 Far Western
SREBF2FHL311259920936779 Two-hybrid
SREBF2FHL310856620936779 Two-hybrid
SREBF2GOLGB111259920936779 Two-hybrid
SREBF2GOLGB110906620936779 Two-hybrid
SREBF2HSPA511259920936779 Two-hybrid
SREBF2HSPA510954120936779 Two-hybrid
SREBF2INSIG111259912202038 12842885 Affinity Capture-Western
SREBF2INSIG110985012202038 12842885 Affinity Capture-Western
SREBF2ITGB411259920936779 Two-hybrid
SREBF2ITGB410989720936779 Two-hybrid
SREBF2KPNB111259911283257 Reconstituted Complex
SREBF2KPNB111003511283257 Reconstituted Complex
SREBF2ABLIM111259920936779 Two-hybrid
SREBF2ABLIM111017120936779 Two-hybrid
SREBF2NFYA11259920936779 Two-hybrid
SREBF2NFYA11086620936779 Two-hybrid
SREBF2NFYC11259920936779 Two-hybrid
SREBF2NFYC11086820936779 Two-hybrid
SREBF2MAPK111259910627507 Biochemical Activity
SREBF2MAPK111158010627507 Biochemical Activity
SREBF2MAPK311259910627507 Biochemical Activity
SREBF2MAPK311158110627507 Biochemical Activity
SREBF2PSMD411259920936779 Two-hybrid
SREBF2PSMD411168320936779 Two-hybrid
SREBF2ATXN111259920936779 Two-hybrid
SREBF2ATXN111221720936779 Two-hybrid
SREBF2SP111259910976766 20936779 Reconstituted Complex; Two-hybrid
SREBF2SP111255010976766 20936779 Reconstituted Complex; Two-hybrid
SREBF2SPTBN111259920936779 Two-hybrid
SREBF2SPTBN111258920936779 Two-hybrid
SREBF2SREBF211259911283257 Reconstituted Complex
UBE2ISREBF211259912615929 20936779 Affinity Capture-Western; Two-hybrid
UBE2ISREBF211317712615929 20936779 Affinity Capture-Western; Two-hybrid
ATF6SREBF211658614765107 Affinity Capture-Western; Reconstituted Complex
ATF6SREBF211259914765107 Affinity Capture-Western; Reconstituted Complex
KLF13SREBF211964216303770 Reconstituted Complex
KLF13SREBF211259916303770 Reconstituted Complex
SUMO1SREBF211259918403372 Reconstituted Complex
SUMO1SREBF211318818403372 Reconstituted Complex
HDAC3SREBF211259918403372 Reconstituted Complex
HDAC3SREBF211436818403372 Reconstituted Complex
LZTR1SREBF211259920211142 Two-hybrid
LZTR1SREBF211385220211142 Two-hybrid
PIAS3SREBF211259920936779 Two-hybrid
PIAS3SREBF211567320936779 Two-hybrid
OS9SREBF211259920936779 Two-hybrid
OS9SREBF211615620936779 Two-hybrid
COPS5SREBF211618320936779 Two-hybrid
COPS5SREBF211259920936779 Two-hybrid
ZDHHC17SREBF211696520936779 Two-hybrid
ZDHHC17SREBF211259920936779 Two-hybrid
ATF7IPSREBF212084920936779 Two-hybrid
ATF7IPSREBF211259920936779 Two-hybrid
TTC1SREBF211259920936779 Two-hybrid
TTC1SREBF211311620936779 Two-hybrid
ZMYM2SREBF211259920936779 Two-hybrid
ZMYM2SREBF211353420936779 Two-hybrid
ZYXSREBF211259920936779 Two-hybrid
ZYXSREBF211356920936779 Two-hybrid
ABLIM2SREBF211259920936779 Two-hybrid
ABLIM2SREBF212408620936779 Two-hybrid
PIAS1SREBF211259920936779 Two-hybrid
PIAS1SREBF211412420936779 Two-hybrid
SLC4A4SREBF211259920936779 Two-hybrid
SLC4A4SREBF211421920936779 Two-hybrid
PIAS2SREBF211452320936779 Two-hybrid
PIAS2SREBF211259920936779 Two-hybrid
ARHGEF1SREBF211259920936779 Two-hybrid
ARHGEF1SREBF211458520936779 Two-hybrid
CASP8AP2SREBF211531520936779 Two-hybrid
CASP8AP2SREBF211259920936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
SREBF2rs1009544, rs10483213, rs1052717, rs11702960, rs12157312, rs12165579, rs13055841, rs133280, rs1569451, rs17002706, rs17002737, rs2006638, rs2229442, rs2267443, rs2269657, rs2269658, rs2269660, rs4822063, rs4822064, rs4822066, rs5751174, rs5996078, rs6002521, rs6002524, rs6002548, rs7290134, rs7364180, rs9623465 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:107585
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070410-8'