AutismKB 2.0

Annotation Details for BRAF


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Basic Information Top
Gene Symbol:BRAF ( B-RAF1,BRAF1,FLJ95109,MGC126806,MGC138284,RAFB1 )
Gene Full Name: v-raf murine sarcoma viral oncogene homolog B1
Band: 7q34
Quick LinksEntrez ID:673; OMIM: 164757; Uniprot ID:BRAF_HUMAN; ENSEMBL ID: ENSG00000157764; HGNC ID: 1097
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IBA-intracellular-
GO:0005634IEA-nucleus-
GO:0005739IEA-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IBA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0043005IEA-neuron projection-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0044297IEA-cell body-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity17563371
GO:0004674IDA-protein serine/threonine kinase activity19667065
GO:0004709IBA-MAP kinase kinase kinase activity-
GO:0005509IDA-calcium ion binding18567582
GO:0005515IPI-protein binding12620389
GO:0005524IEA-ATP binding-
GO:0031267IPINOTsmall GTPase binding12194967
GO:0031434IBA-mitogen-activated protein kinase kinase binding-
GO:0042802IPI-identical protein binding16858395
GO:0046982IEA-protein heterodimerization activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000186IEA-activation of MAPKK activity-
GO:0002318IEA-myeloid progenitor cell differentiation-
GO:0006468IDA-protein phosphorylation17563371
GO:0008542IEA-visual learning-
GO:0009887TAS-animal organ morphogenesis9207797
GO:0009968IBA-negative regulation of signal transduction-
GO:0010628IMP-positive regulation of gene expression22065586
GO:0010764IEA-negative regulation of fibroblast migration-
GO:0015758IDA-glucose transport23010278
GO:0030154IBA-cell differentiation-
GO:0030878IEA-thyroid gland development-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19667065
GO:0035019IEA-somatic stem cell population maintenance-
GO:0035690IEA-cellular response to drug-
GO:0042127IEA-regulation of cell proliferation-
GO:0043066IDA-negative regulation of apoptotic process19667065
GO:0043367IEA-CD4-positive, alpha-beta T cell differentiation-
GO:0043369IEA-CD4-positive or CD8-positive, alpha-beta T cell lineage commitment-
GO:0043434IEA-response to peptide hormone-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045580IEA-regulation of T cell differentiation-
GO:0048538IEA-thymus development-
GO:0048680IEA-positive regulation of axon regeneration-
GO:0050772IEA-positive regulation of axonogenesis-
GO:0050852IEA-T cell receptor signaling pathway-
GO:0051291IEA-protein heterooligomerization-
GO:0051496IEA-positive regulation of stress fiber assembly-
GO:0051591IEA-response to cAMP-
GO:0060291IEA-long-term synaptic potentiation-
GO:0060323IEA-head morphogenesis-
GO:0060324IEA-face development-
GO:0070374IDA-positive regulation of ERK1 and ERK2 cascade22065586
GO:0071277IDA-cellular response to calcium ion18567582
GO:0090150IDA-establishment of protein localization to membrane23010278
GO:1900026IEA-positive regulation of substrate adhesion-dependent cell spreading-
GO:1990090IEA-cellular response to nerve growth factor stimulus-
GO:2000301IEA-negative regulation of synaptic vesicle exocytosis-
GO:2000352IEA-negative regulation of endothelial cell apoptotic process-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BRAFAKT110671010869359 Affinity Capture-Western; Biochemical Activity
BRAFAKT110714110869359 Affinity Capture-Western; Biochemical Activity
HRASBRAF1095017706312 9154803 Reconstituted Complex; Two-hybrid
HRASBRAF1071417706312 9154803 Reconstituted Complex; Two-hybrid
RAP1ABRAF10714110454553 Reconstituted Complex
RAP1ABRAF11184110454553 Reconstituted Complex
MAPK3BRAF11158110869359 Phenotypic Enhancement
MAPK3BRAF10714110869359 Phenotypic Enhancement
YWHABBRAF10714110931830 17353931 Affinity Capture-MS; Affinity Capture-Western
YWHABBRAF11336110931830 17353931 Affinity Capture-MS; Affinity Capture-Western
RAP1GAPBRAF10714111278445 Reconstituted Complex
RAP1GAPBRAF11184411278445 Reconstituted Complex
RAF1BRAF10714111325826 Affinity Capture-Western
RAF1BRAF11183111325826 Affinity Capture-Western
MRASBRAF11648612138204 Affinity Capture-Western
MRASBRAF10714112138204 Affinity Capture-Western
SFNBRAF10907215778465 Affinity Capture-MS
SFNBRAF10714115778465 Affinity Capture-MS
YWHAQBRAF11616817353931 Affinity Capture-MS
YWHAQBRAF10714117353931 Affinity Capture-MS
YWHAGBRAF11336417353931 Affinity Capture-MS
YWHAGBRAF10714117353931 Affinity Capture-MS
YWHAZBRAF10714117353931 Affinity Capture-MS
YWHAZBRAF11336617353931 Affinity Capture-MS
PAK2BRAF11109820936779 Two-hybrid
PAK2BRAF10714120936779 Two-hybrid
CCDC88ABRAF12082920936779 Two-hybrid
CCDC88ABRAF10714120936779 Two-hybrid
TERF1BRAF10714120936779 Two-hybrid
TERF1BRAF11287220936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:88190
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040805-1'