AutismKB 2.0

Annotation Details for BRCA2


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Basic Information Top
Gene Symbol:BRCA2 ( BRCC2,BROVCA2,FACD,FAD,FAD1,FANCB,FANCD,FANCD1,GLM3,PNCA2 )
Gene Full Name: breast cancer 2, early onset
Band: 13q13.1
Quick LinksEntrez ID:675; OMIM: 600185; Uniprot ID:BRCA2_HUMAN; ENSEMBL ID: ENSG00000139618; HGNC ID: 1101
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000784IDA-nuclear chromosome, telomeric region21076401
GO:0000800IDA-lateral element9774970
GO:0005634IDA-nucleus9560268
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005813IDA-centrosome17286961
GO:0005829IDA-cytosol-
GO:0030141IDA-secretory granule8589722
GO:0033593IDA-BRCA2-MAGE-D1 complex15930293
GO:0043234IDA-protein complex9774970
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding15314155
GO:0003697IDA-single-stranded DNA binding20729832
GO:0004402IDANOThistone acetyltransferase activity9824164
GO:0005515IPI-protein binding9560268
GO:0008022IDA-protein C-terminus binding9774970
GO:0010484IDA-H3 histone acetyltransferase activity9619837
GO:0010485IDA-H4 histone acetyltransferase activity9619837
GO:0043015IPI-gamma-tubulin binding17286961
GO ID Evidence Qualifier GO_term References
GO:0000722IEA-telomere maintenance via recombination-
GO:0000724IDA-double-strand break repair via homologous recombination20729832
GO:0000724IMP-double-strand break repair via homologous recombination21719596
GO:0000731TAS-DNA synthesis involved in DNA repair-
GO:0000732TAS-strand displacement-
GO:0000910IDA-cytokinesis17286961
GO:0001556IEA-oocyte maturation-
GO:0001833IEA-inner cell mass cell proliferation-
GO:0006289IMP-nucleotide-excision repair16845393
GO:0006302IMP-double-strand break repair16845393
GO:0006978IEA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator-
GO:0007141IEA-male meiosis I-
GO:0007283IEA-spermatogenesis-
GO:0007420IEA-brain development-
GO:0007569IEA-cell aging-
GO:0008585IEA-female gonad development-
GO:0010165IEA-response to X-ray-
GO:0010225IEA-response to UV-C-
GO:0010332IEA-response to gamma radiation-
GO:0030097IEA-hemopoiesis-
GO:0032465IEA-regulation of cytokinesis-
GO:0033600IDA-negative regulation of mammary gland epithelial cell proliferation15930293
GO:0042771IEA-intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator-
GO:0043966IDA-histone H3 acetylation9619837
GO:0043967IDA-histone H4 acetylation9619837
GO:0045893IDA-positive regulation of transcription, DNA-templated9126734
GO:0045931IEA-positive regulation of mitotic cell cycle-
GO:0048478IEA-replication fork protection-
GO:0051298IMP-centrosome duplication17286961
GO:0070200IDA-establishment of protein localization to telomere21076401
GO:1990426IMP-mitotic recombination-dependent replication fork processing21076401
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
BRCA2ATM10714215199141 Reconstituted Complex
BRCA2ATM10696215199141 Reconstituted Complex
BRCA2ATR10702710608806 Protein-peptide
BRCA2ATR10714210608806 Protein-peptide
BRCA2BACH110714217664283 Affinity Capture-Western
BRCA2BACH110704717664283 Affinity Capture-Western
BRCA2BARD110705614636569 17664283 19176389 Affinity Capture-Western; Co-purification; Reconstituted Complex
BRCA2BARD110714214636569 17664283 19176389 Affinity Capture-Western; Co-purification; Reconstituted Complex
BRCA2BRCA11071429774970 11477095 14499622 14636569 17664283 21135251 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
BRCA2BRCA11071409774970 11477095 14499622 14636569 17664283 21135251 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
RAD51BRCA21071429126738 9405383 9523196 9560268 9774970 9811893 11313963 11477095 12442171 12815053 14580352 14636569 15065660 15671039 16914443 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
RAD51BRCA21118259126738 9405383 9523196 9560268 9774970 9811893 11313963 11477095 12442171 12815053 14580352 14636569 15065660 15671039 16914443 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex; Two-hybrid
TP53BRCA21130109811893 14636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
TP53BRCA21071429811893 14636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
KAT2BBRCA21143759824164 12815053 Affinity Capture-Western; Reconstituted Complex
KAT2BBRCA21071429824164 12815053 Affinity Capture-Western; Reconstituted Complex
SHFM1BRCA210714210373512 12228710 Affinity Capture-Western; Co-crystal Structure; Two-hybrid
SHFM1BRCA211369210373512 12228710 Affinity Capture-Western; Co-crystal Structure; Two-hybrid
BUB1BBRCA210714210749118 Reconstituted Complex; Two-hybrid
BUB1BBRCA210716610749118 Reconstituted Complex; Two-hybrid
HMG20BBRCA211564211207365 12032298 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
HMG20BBRCA210714211207365 12032298 Affinity Capture-MS; Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
BCCIPBRCA210714211313963 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BCCIPBRCA212116111313963 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNABRCA210714211602572 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FLNABRCA210860511602572 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SMAD2BRCA211026212165866 Affinity Capture-Western
SMAD2BRCA210714212165866 Affinity Capture-Western
SMAD3BRCA210714212165866 Affinity Capture-Western; Reconstituted Complex
SMAD3BRCA211026312165866 Affinity Capture-Western; Reconstituted Complex
STAT5ABRCA210714212459499 Affinity Capture-Western
STAT5ABRCA211265312459499 Affinity Capture-Western
RPA1BRCA210714212527904 Affinity Capture-Western; Reconstituted Complex
RPA1BRCA211203712527904 Affinity Capture-Western; Reconstituted Complex
PLK1BRCA211136212815053 14647413 Affinity Capture-Western; Reconstituted Complex
PLK1BRCA210714212815053 14647413 Affinity Capture-Western; Reconstituted Complex
FANCGBRCA210714212915460 20450923 Affinity Capture-Western; Two-hybrid
FANCGBRCA210848412915460 20450923 Affinity Capture-Western; Two-hybrid
BRCC3BRCA212259914636569 17664283 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BRCC3BRCA210714214636569 17664283 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BREBRCA210714214636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
BREBRCA211494614636569 Affinity Capture-MS; Affinity Capture-Western; Co-purification
C11orf30BRCA212127014651845 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
C11orf30BRCA210714214651845 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
FANCD2BRCA210714215115758 15199141 18263878 20450923 Affinity Capture-Western; Co-localization; Two-hybrid
FANCD2BRCA210847415115758 15199141 18263878 20450923 Affinity Capture-Western; Co-localization; Two-hybrid
FANCEBRCA210714215199141 Affinity Capture-Western
FANCEBRCA210847515199141 Affinity Capture-Western
USP11BRCA211386615314155 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
USP11BRCA210714215314155 Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity
UBCBRCA211316415314155 15805113 16754685 Affinity Capture-Western
UBCBRCA210714215314155 15805113 16754685 Affinity Capture-Western
SKP2BRCA210714216754685 Affinity Capture-Western
SKP2BRCA211239316754685 Affinity Capture-Western
PMS2BRCA210714217148452 Affinity Capture-MS
PMS2BRCA211140417148452 Affinity Capture-MS
PMS1BRCA211139117148452 Affinity Capture-Western
PMS1BRCA210714217148452 Affinity Capture-Western
CHEK2BRCA211636917525332 Affinity Capture-Western
CHEK2BRCA210714217525332 Affinity Capture-Western
H2AFXBRCA210926818406329 Affinity Capture-MS; Affinity Capture-Western
H2AFXBRCA210714218406329 Affinity Capture-MS; Affinity Capture-Western
KIF4ABRCA211728818604178 Affinity Capture-Western
KIF4ABRCA210714218604178 Affinity Capture-Western
SP1BRCA211255018769160 Affinity Capture-Western
SP1BRCA210714218769160 Affinity Capture-Western
AURKBBRCA211464619176389 Affinity Capture-Western
AURKBBRCA210714219176389 Affinity Capture-Western
MCPH1BRCA212277619549900 20107607 Affinity Capture-Western; Co-localization
MCPH1BRCA210714219549900 20107607 Affinity Capture-Western; Co-localization
UQCCBRCA212053619578754 Reconstituted Complex
UQCCBRCA210714219578754 Reconstituted Complex
SERPINH1BRCA210714219578754 Reconstituted Complex
SERPINH1BRCA210731819578754 Reconstituted Complex
XRCC3BRCA211335120450923 Affinity Capture-Western
XRCC3BRCA210714220450923 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
BRCA2rs9567552 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109337
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-060510-3'