AutismKB 2.0

Annotation Details for STAT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:STAT1 ( DKFZp686B04100,ISGF-3,STAT91 )
Gene Full Name: signal transducer and activator of transcription 1, 91kDa
Band: 2q32.2
Quick LinksEntrez ID:6772; OMIM: 600555; Uniprot ID:STAT1_HUMAN; ENSEMBL ID: ENSG00000115415; HGNC ID: 11362
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin18035482
GO:0005634IDA-nucleus10692450
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus-
GO:0005737IDA-cytoplasm10692450
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0030424ISS-axon-
GO:0030425ISS-dendrite-
GO:0048471IDA-perinuclear region of cytoplasm17275127
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding18035482
GO:0000979IDA-RNA polymerase II core promoter sequence-specific DNA binding21268089
GO:0000983IDA-transcription factor activity, RNA polymerase II core promoter sequence-specific21268089
GO:0003690IDA-double-stranded DNA binding9630226
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding10973496
GO:0004871IEA-signal transducer activity-
GO:0005164IPI-tumor necrosis factor receptor binding10848577
GO:0005515IPI-protein binding8156998
GO:0019899IPI-enzyme binding22002246
GO:0035257IPI-nuclear hormone receptor binding26504087
GO:0042802IPI-identical protein binding8605877
GO:0042803IDA-protein homodimerization activity9630226
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000122ISS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001937IMP-negative regulation of endothelial cell proliferation16585190
GO:0002053ISS-positive regulation of mesenchymal cell proliferation-
GO:0003340ISS-negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis-
GO:0006351IEA-transcription, DNA-templated-
GO:0006915ISS-apoptotic process-
GO:0007259IDA-JAK-STAT cascade22002246
GO:0008015ISS-blood circulation-
GO:0010742IDA-macrophage derived foam cell differentiation26504087
GO:0016525IMP-negative regulation of angiogenesis16585190
GO:0033209IDA-tumor necrosis factor-mediated signaling pathway10848577
GO:0034097ISS-response to cytokine-
GO:0035456IMP-response to interferon-beta24882218
GO:0035458IMP-cellular response to interferon-beta18035482
GO:0042981TAS-regulation of apoptotic process12108949
GO:0043124IMP-negative regulation of I-kappaB kinase/NF-kappaB signaling10848577
GO:0043434ISS-response to peptide hormone-
GO:0043542IMPNOTendothelial cell migration16585190
GO:0045648IMP-positive regulation of erythrocyte differentiation28283061
GO:0045893IDA-positive regulation of transcription, DNA-templated10973496
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18035482
GO:0046725IMP-negative regulation by virus of viral protein levels in host cell15825084
GO:0048661ISS-positive regulation of smooth muscle cell proliferation-
GO:0051591ISS-response to cAMP-
GO:0051607IEA-defense response to virus-
GO:0060333IDA-interferon-gamma-mediated signaling pathway21268089
GO:0060333ISS-interferon-gamma-mediated signaling pathway-
GO:0060333TAS-interferon-gamma-mediated signaling pathway-
GO:0060334TAS-regulation of interferon-gamma-mediated signaling pathway-
GO:0060337ISS-type I interferon signaling pathway-
GO:0060337TAS-type I interferon signaling pathway-
GO:0060338TAS-regulation of type I interferon-mediated signaling pathway-
GO:0061326IMP-renal tubule development20861313
GO:0072136ISS-metanephric mesenchymal cell proliferation involved in metanephros development-
GO:0072162ISS-metanephric mesenchymal cell differentiation-
GO:0072308ISS-negative regulation of metanephric nephron tubule epithelial cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STAT1ACTN410659620936779 Two-hybrid
STAT1ACTN411264920936779 Two-hybrid
STAT1BCL310707416306601 Affinity Capture-Western
STAT1BCL311264916306601 Affinity Capture-Western
STAT1BRCA110714010792030 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT1BRCA111264910792030 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STAT1CREBBP1077778986769 9037008 15695802 15894584 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
STAT1CREBBP1126498986769 9037008 15695802 15894584 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex
STAT1DCTN110800720936779 Two-hybrid
STAT1DCTN111264920936779 Two-hybrid
STAT1EGFR11264910358079 12070153 Affinity Capture-Western
STAT1EGFR10827610358079 12070153 Affinity Capture-Western
STAT1EP30010834710464260 11923478 12403783 Affinity Capture-Western
STAT1EP30011264910464260 11923478 12403783 Affinity Capture-Western
STAT1FANCC11264910848598 11520787 14499622 Affinity Capture-Western; Two-hybrid
STAT1FANCC10847310848598 11520787 14499622 Affinity Capture-Western; Two-hybrid
STAT1MTOR10875712807916 Affinity Capture-Western
STAT1MTOR11264912807916 Affinity Capture-Western
STAT1GFAP11264920936779 Two-hybrid
STAT1GFAP10893820936779 Two-hybrid
STAT1GTF2I1126499584171 Reconstituted Complex
STAT1GTF2I1092249584171 Reconstituted Complex
STAT1HSF11095309880553 Affinity Capture-Western
STAT1HSF11126499880553 Affinity Capture-Western
STAT1HSP90AB110955820936779 Two-hybrid
STAT1HSP90AB111264920936779 Two-hybrid
STAT1IFNAR21096779121453 11301323 Reconstituted Complex
STAT1IFNAR21126499121453 11301323 Reconstituted Complex
STAT1IL2RB10977510602027 Reconstituted Complex
STAT1IL2RB11264910602027 Reconstituted Complex
STAT1IRF110986710764778 16512786 Affinity Capture-Western; Reconstituted Complex
STAT1IRF111264910764778 16512786 Affinity Capture-Western; Reconstituted Complex
STAT1JUN10992810490649 Affinity Capture-Western
STAT1JUN11264910490649 Affinity Capture-Western
STAT1KIT1100159355737 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT1KIT1126499355737 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
STAT1KPNA111003412048190 Reconstituted Complex
STAT1KPNA111264912048190 Reconstituted Complex
STAT1LMO211019116189514 Two-hybrid
STAT1LMO211264916189514 Two-hybrid
STAT1MBD111032219074829 Affinity Capture-Western
STAT1MBD111264919074829 Affinity Capture-Western
STAT1MCM51103429843502 11248027 Affinity Capture-Western; Reconstituted Complex
STAT1MCM51126499843502 11248027 Affinity Capture-Western; Reconstituted Complex
STAT1PRKCD11156612807916 Affinity Capture-Western
STAT1PRKCD11264912807916 Affinity Capture-Western
STAT1EIF2AK21126499135145 11278865 Affinity Capture-Western; Reconstituted Complex
STAT1EIF2AK21115969135145 11278865 Affinity Capture-Western; Reconstituted Complex
STAT1PTK211171911278462 Affinity Capture-Western; Reconstituted Complex
STAT1PTK211264911278462 Affinity Capture-Western; Reconstituted Complex
STAT1PTPN211264919171783 Affinity Capture-Western
STAT1PTPN211173719171783 Affinity Capture-Western
STAT1SMARCA411264916195385 Co-localization
STAT1SMARCA411248116195385 Co-localization
STAT1SPTAN111264920936779 Two-hybrid
STAT1SPTAN111258720936779 Two-hybrid
STAT1SPTBN111264920936779 Two-hybrid
STAT1SPTBN111258920936779 Two-hybrid
STAT1SRC1126499344858 10358079 Affinity Capture-Western
STAT1SRC1125929344858 10358079 Affinity Capture-Western
STAT2STAT11126498621447 10446176 12048190 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
STAT2STAT11126508621447 10446176 12048190 Affinity Capture-Western; Co-localization; Co-purification; Reconstituted Complex
STAT1STAT11126498621447 9630226 15284440 Co-crystal Structure; Co-purification; Two-hybrid
IRF9STAT11126498943351 Reconstituted Complex; Two-hybrid
IRF9STAT11156528943351 Reconstituted Complex; Two-hybrid
NMISTAT11145619989503 Reconstituted Complex
NMISTAT11126499989503 Reconstituted Complex
PIAS1STAT111412410805787 Reconstituted Complex; Two-hybrid
PIAS1STAT111264910805787 Reconstituted Complex; Two-hybrid
TNFRSF1ASTAT111298610848577 Affinity Capture-Western
TNFRSF1ASTAT111264910848577 Affinity Capture-Western
TRADDSTAT111425710848577 Affinity Capture-Western; Reconstituted Complex
TRADDSTAT111264910848577 Affinity Capture-Western; Reconstituted Complex
ELP2STAT111264910954736 Reconstituted Complex
ELP2STAT112054110954736 Reconstituted Complex
GNB2L1STAT111264911301323 12960323 Affinity Capture-Western; Reconstituted Complex
GNB2L1STAT111567111301323 12960323 Affinity Capture-Western; Reconstituted Complex
STAT3STAT111264911594781 11722592 12070153 Affinity Capture-Western
STAT3STAT111265111594781 11722592 12070153 Affinity Capture-Western
VDRSTAT111264911909970 Affinity Capture-Western; Reconstituted Complex
VDRSTAT111326411909970 Affinity Capture-Western; Reconstituted Complex
IL27RASTAT111264912734330 Affinity Capture-Western; Reconstituted Complex
IL27RASTAT111485212734330 Affinity Capture-Western; Reconstituted Complex
TYK2STAT111264912960323 Biochemical Activity
TYK2STAT111314812960323 Biochemical Activity
EIF1ADSTAT111264916189514 Two-hybrid
EIF1ADSTAT112401216189514 Two-hybrid
C20orf185STAT111264917353931 Affinity Capture-MS
C20orf185STAT113170417353931 Affinity Capture-MS
TRIM28STAT111264918381204 Affinity Capture-Western
TRIM28STAT111545718381204 Affinity Capture-Western
RNF11STAT111264919131965 Affinity Capture-Western
RNF11STAT111794119131965 Affinity Capture-Western
LZTR1STAT111264920211142 Two-hybrid
LZTR1STAT111385220211142 Two-hybrid
SHANK1STAT111264920936779 Two-hybrid
SHANK1STAT111917120936779 Two-hybrid
CTNNBL1STAT111264921385873 Affinity Capture-MS
CTNNBL1STAT112112321385873 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
STAT2STAT118261515467722 STAT1 interacts with STAT2.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103063
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030616-23'