AutismKB 2.0

Annotation Details for STK4


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Basic Information Top
Gene Symbol:STK4 ( DKFZp686A2068,KRS2,MST1,YSK3 )
Gene Full Name: serine/threonine kinase 4
Band: 20q13.12
Quick LinksEntrez ID:6789; OMIM: 604965; Uniprot ID:STK4_HUMAN; ENSEMBL ID: ENSG00000101109; HGNC ID: 11408
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus17932490
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm17932490
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016604IDA-nuclear body-
GO:0043234IDA-protein complex19962960
GO ID Evidence Qualifier GO_term References
GO:0000287IDA-magnesium ion binding8566796
GO:0004672IGI-protein kinase activity19962960
GO:0004674EXP-protein serine/threonine kinase activity9545236
GO:0004674IDA-protein serine/threonine kinase activity8566796
GO:0004702IBA-signal transducer, downstream of receptor, with serine/threonine kinase activity-
GO:0005515IPI-protein binding14729613
GO:0005524IDA-ATP binding8566796
GO:0008134IPI-transcription factor binding16751106
GO:0042802IPI-identical protein binding8702870
GO:0042803IDA-protein homodimerization activity11805089
GO:0043539TAS-protein serine/threonine kinase activator activity20412773
GO:0046983IDA-protein dimerization activity8702870
GO ID Evidence Qualifier GO_term References
GO:0000902IDA-cell morphogenesis11805089
GO:0001569IEA-branching involved in blood vessel morphogenesis-
GO:0001841IEA-neural tube formation-
GO:0001934IDA-positive regulation of protein phosphorylation19962960
GO:0003157IEA-endocardium development-
GO:0006468IDA-protein phosphorylation8566796
GO:0006915IDA-apoptotic process21212262
GO:0007165TAS-signal transduction7665586
GO:0007417IEA-central nervous system development-
GO:0008285IEA-negative regulation of cell proliferation-
GO:0018105IDA-peptidyl-serine phosphorylation16751106
GO:0023014IEA-signal transduction by protein phosphorylation-
GO:0030216IEA-keratinocyte differentiation-
GO:0032092IDA-positive regulation of protein binding22292086
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19962960
GO:0035329IDA-hippo signaling20412773
GO:0035329TAS-hippo signaling19484742
GO:0035556IDA-intracellular signal transduction8566796
GO:0043065IDA-positive regulation of apoptotic process15109305
GO:0045600IEA-positive regulation of fat cell differentiation-
GO:0046621IEA-negative regulation of organ growth-
GO:0046777IDA-protein autophosphorylation11805089
GO:0050821IDA-protein stabilization19962960
GO:0060215IEA-primitive hemopoiesis-
GO:0060706IEA-cell differentiation involved in embryonic placenta development-
GO:0060800IEA-regulation of cell differentiation involved in embryonic placenta development-
GO:0071902IEA-positive regulation of protein serine/threonine kinase activity-
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway20412773
GO:0097284IEA-hepatocyte apoptotic process-
GO:1902043IEA-positive regulation of extrinsic apoptotic signaling pathway via death domain receptors-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STK4MAP1B11030420562859 Affinity Capture-MS
STK4MAP1B11266520562859 Affinity Capture-MS
STK4PRKRIR11159812384512 Affinity Capture-Western; Reconstituted Complex
STK4PRKRIR11266512384512 Affinity Capture-Western; Reconstituted Complex
STK4STK311266420562859 Affinity Capture-MS
STK4STK311266520562859 Affinity Capture-MS
STK4STK41126658702870 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HIST2H2BESTK411266512757711 Biochemical Activity
HIST2H2BESTK411394512757711 Biochemical Activity
CNKSR1STK411266515075335 Affinity Capture-Western
CNKSR1STK411555015075335 Affinity Capture-Western
C20orf94STK411266519596235 Affinity Capture-MS
C20orf94STK412614719596235 Affinity Capture-MS
RASSF1STK411635620562859 Affinity Capture-MS
RASSF1STK411266520562859 Affinity Capture-MS
TAOK1STK411266520562859 Affinity Capture-MS
TAOK1STK412160720562859 Affinity Capture-MS
SAV1STK412191720562859 Affinity Capture-MS
SAV1STK411266520562859 Affinity Capture-MS
MAP1LC3BSTK411266520562859 Affinity Capture-MS
MAP1LC3BSTK412356520562859 Affinity Capture-MS
RASSF5STK411266520562859 Affinity Capture-MS
RASSF5STK412368920562859 Affinity Capture-MS
RASSF4STK411266520562859 Affinity Capture-MS
RASSF4STK412382020562859 Affinity Capture-MS
MAP1LC3ASTK412413720562859 Affinity Capture-MS
MAP1LC3ASTK411266520562859 Affinity Capture-MS
RASSF2STK411266520562859 Affinity Capture-MS
RASSF2STK411511520562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
STK4D20S119 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1929004
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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