AutismKB 2.0

Annotation Details for CDKL5


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:CDKL5 ( ISSX,STK9 )
Gene Full Name: cyclin-dependent kinase-like 5
Band: Xp22.13
Quick LinksEntrez ID:6792; OMIM: 300203; Uniprot ID:CDKL5_HUMAN; ENSEMBL ID: ENSG00000008086; HGNC ID: 11411
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16935860
GO:0005654IDA-nucleoplasm-
GO:0005829IDA-cytosol-
GO:0032587ISScolocalizes_withruffle membrane-
GO:0032839IBA-dendrite cytoplasm-
GO:0032839ISS-dendrite cytoplasm-
GO:0044294ISS-dendritic growth cone-
GO:0045202IEA-synapse-
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity16935860
GO:0004674TAS-protein serine/threonine kinase activity9721213
GO:0004693IBANOTcyclin-dependent protein serine/threonine kinase activity-
GO:0005524IDA-ATP binding16935860
GO:0016301IDA-kinase activity15917271
GO:0048365ISS-Rac GTPase binding-
GO ID Evidence Qualifier GO_term References
GO:0001764ISS-neuron migration-
GO:0006468TAS-protein phosphorylation9721213
GO:0043547ISS-positive regulation of GTPase activity-
GO:0045773IBA-positive regulation of axon extension-
GO:0045773ISS-positive regulation of axon extension-
GO:0046777IDA-protein autophosphorylation16935860
GO:0050773IBA-regulation of dendrite development-
GO:0050773ISS-regulation of dendrite development-
GO:0050775ISS-positive regulation of dendrite morphogenesis-
GO:0060999IEA-positive regulation of dendritic spine development-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CDKL5MECP211266815917271 Affinity Capture-Western; Reconstituted Complex
CDKL5MECP211036815917271 Affinity Capture-Western; Reconstituted Complex
CDKL5MGMT11041116226712 Affinity Capture-MS
CDKL5MGMT11266816226712 Affinity Capture-MS
CDKL5CDKL511266816935860 Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-081022-110'