AutismKB 2.0

Annotation Details for STX1A


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Basic Information Top
Gene Symbol:STX1A ( HPC-1,P35-1,STX1,SYN1A )
Gene Full Name: syntaxin 1A (brain)
Band: 7q11.23
Quick LinksEntrez ID:6804; OMIM: 186590; Uniprot ID:STX1A_HUMAN; ENSEMBL ID: ENSG00000106089; HGNC ID: 11433
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12730201
GO:0005886TAS-plasma membrane10099709
GO:0008021IBA-synaptic vesicle-
GO:0008076ISScolocalizes_withvoltage-gated potassium channel complex-
GO:0014069IEA-postsynaptic density-
GO:0016021IBA-integral component of membrane-
GO:0030054IEA-cell junction-
GO:0030141IEA-secretory granule-
GO:0030672IEA-synaptic vesicle membrane-
GO:0031201IDA-SNARE complex12730201
GO:0031201TAS-SNARE complex10099709
GO:0031965IEA-nuclear membrane-
GO:0042641IEA-actomyosin-
GO:0043005IDA-neuron projection12115694
GO:0048787IEA-presynaptic active zone membrane-
GO:0070032IEA-synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-
GO:0070033IEA-synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex-
GO:0070044IEA-synaptobrevin 2-SNAP-25-syntaxin-1a complex-
GO ID Evidence Qualifier GO_term References
GO:0000149IBA-SNARE binding-
GO:0001948IEA-glycoprotein binding-
GO:0005484IBA-SNAP receptor activity-
GO:0005515IPI-protein binding10321247
GO:0017022IBA-myosin binding-
GO:0019855IEA-calcium channel inhibitor activity-
GO:0019869IDA-chloride channel inhibitor activity18570918
GO:0019900IPI-kinase binding12730201
GO:0019904IEA-protein domain specific binding-
GO:0030674IEA-protein binding, bridging-
GO:0032028IEA-myosin head/neck binding-
GO:0043008IEA-ATP-dependent protein binding-
GO:0044325IEA-ion channel binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0047485IEA-protein N-terminus binding-
GO:0048306IEA-calcium-dependent protein binding-
GO ID Evidence Qualifier GO_term References
GO:0001956IEA-positive regulation of neurotransmitter secretion-
GO:0006886IBA-intracellular protein transport-
GO:0007269TAS-neurotransmitter secretion-
GO:0009629IEA-response to gravity-
GO:0010701ISS-positive regulation of norepinephrine secretion-
GO:0010807IEA-regulation of synaptic vesicle priming-
GO:0014047TAS-glutamate secretion-
GO:0016081IEA-synaptic vesicle docking-
GO:0031629IBA-synaptic vesicle fusion to presynaptic active zone membrane-
GO:0032940IDA-secretion by cell12130530
GO:0033605ISS-positive regulation of catecholamine secretion-
GO:0035493IEA-SNARE complex assembly-
GO:0045956ISS-positive regulation of calcium ion-dependent exocytosis-
GO:0048278IBA-vesicle docking-
GO:0050796TAS-regulation of insulin secretion15537656
GO:0065009IEA-regulation of molecular function-
GO:0072657IEA-protein localization to membrane-
GO:2000463IEA-positive regulation of excitatory postsynaptic potential-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STX1AATP6V1B111267612651853 Reconstituted Complex
STX1AATP6V1B110700812651853 Reconstituted Complex
STX1ACDK51126769478941 Reconstituted Complex
STX1ACDK51074559478941 Reconstituted Complex
STX1ACFTR1126769384384 12209004 Affinity Capture-Western; Reconstituted Complex
STX1ACFTR1075069384384 12209004 Affinity Capture-Western; Reconstituted Complex
STX1ATRDMT111267616169070 Two-hybrid
STX1ATRDMT110812416169070 Two-hybrid
STX1ASCNN1A11267614996668 Affinity Capture-Western
STX1ASCNN1A11224114996668 Affinity Capture-Western
STX1ASCNN1B11224214996668 Affinity Capture-Western
STX1ASCNN1B11267614996668 Affinity Capture-Western
STX1ASCNN1G11224414996668 Affinity Capture-Western; Reconstituted Complex
STX1ASCNN1G11267614996668 Affinity Capture-Western; Reconstituted Complex
STX1ASLC6A11126769698305 11017172 11960023 Affinity Capture-Western; Reconstituted Complex
STX1ASLC6A11124209698305 11017172 11960023 Affinity Capture-Western; Reconstituted Complex
STX1ASLC6A411267612175857 Affinity Capture-Western
STX1ASLC6A411242312175857 Affinity Capture-Western
STX1ASLC6A911267610722844 Affinity Capture-Western
STX1ASLC6A911242710722844 Affinity Capture-Western
STX1ASNAP251126767553862 7768895 7961655 8663154 9852078 10195194 10449403 10954418 11524423 11832227 16169070 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
STX1ASNAP251125007553862 7768895 7961655 8663154 9852078 10195194 10449403 10954418 11524423 11832227 16169070 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
SYPSTX1A1126767553862 Affinity Capture-Western
SYPSTX1A1127217553862 Affinity Capture-Western
VAMP2STX1A1126767553862 9030619 10100611 10449403 11832227 12093152 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
VAMP2STX1A1127117553862 9030619 10100611 10449403 11832227 12093152 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
STXBP1STX1A1126767553862 7768895 10449403 12093152 12963086 Affinity Capture-Western; Reconstituted Complex
STXBP1STX1A1126817553862 7768895 10449403 12093152 12963086 Affinity Capture-Western; Reconstituted Complex
NAPASTX1A1126767553862 7622514 Affinity Capture-Western; Reconstituted Complex
NAPASTX1A1143057553862 7622514 Affinity Capture-Western; Reconstituted Complex
STXBP2STX1A1126767768895 Reconstituted Complex
STXBP2STX1A1126827768895 Reconstituted Complex
SNAP23STX1A1143038663154 9168999 9852078 12651853 12828989 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SNAP23STX1A1126768663154 9168999 9852078 12651853 12828989 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UNC13BSTX1A1157598999968 Co-fractionation; Two-hybrid
UNC13BSTX1A1126768999968 Co-fractionation; Two-hybrid
SYT1STX1A1126769010211 10397765 Reconstituted Complex
SYT1STX1A1127239010211 10397765 Reconstituted Complex
STXBP5STX1A1126769620695 12832401 Reconstituted Complex
STXBP5STX1A1264179620695 12832401 Reconstituted Complex
SNAP29STX1A1147489852078 Reconstituted Complex
SNAP29STX1A1126769852078 Reconstituted Complex
STX1ASTX1A11267610100611 Reconstituted Complex
CPLX2STX1A11602710449403 Affinity Capture-Western
CPLX2STX1A11267610449403 Affinity Capture-Western
CPLX1STX1A11267610449403 11832227 12200427 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
CPLX1STX1A11602810449403 11832227 12200427 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
SLC6A5STX1A11459910722844 Affinity Capture-Western
SLC6A5STX1A11267610722844 Affinity Capture-Western
VAMP8STX1A11422111112705 Affinity Capture-Western; Reconstituted Complex
VAMP8STX1A11267611112705 Affinity Capture-Western; Reconstituted Complex
VAMP1STX1A11267612093152 Two-hybrid
VAMP1STX1A11271012093152 Two-hybrid
SYTL4STX1A12512012101244 12590134 Affinity Capture-Western; Reconstituted Complex
SYTL4STX1A11267612101244 12590134 Affinity Capture-Western; Reconstituted Complex
RNF40STX1A11267612121982 Affinity Capture-Western; Reconstituted Complex
RNF40STX1A11514912121982 Affinity Capture-Western; Reconstituted Complex
TXLNASTX1A12829712558796 Reconstituted Complex
TXLNASTX1A11267612558796 Reconstituted Complex
VAPBSTX1A11465012651853 Reconstituted Complex
VAPBSTX1A11267612651853 Reconstituted Complex
VAMP7STX1A11267612853575 Reconstituted Complex
VAMP7STX1A11271212853575 Reconstituted Complex
TXLNBSTX1A11267615184072 Reconstituted Complex
TXLNBSTX1A12795215184072 Reconstituted Complex
FAM190BSTX1A11996816169070 Two-hybrid
FAM190BSTX1A11267616169070 Two-hybrid
VIMSTX1A11267616169070 Two-hybrid
VIMSTX1A11327216169070 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
STX1AIntron7 SNP, STX1A_intron 7 RFLP, rs1569061, rs2030921, rs2293485, rs3793243, rs4363087, rs6951030, rs867500, rs875342, rs9654749 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109355
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-100802-1'