AutismKB 2.0

Annotation Details for STX4


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Basic Information Top
Gene Symbol:STX4 ( STX4A,p35-2 )
Gene Full Name: syntaxin 4
Band: 16p11.2
Quick LinksEntrez ID:6810; OMIM: 186591; Uniprot ID:STX4_HUMAN; ENSEMBL ID: ENSG00000103496; HGNC ID: 11439
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000322IEA-storage vacuole-
GO:0005615IDA-extracellular space22226963
GO:0005622IDA-intracellular24055037
GO:0005768IDA-endosome20956541
GO:0005773TAS-vacuole16339081
GO:0005802IEA-trans-Golgi network-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane20956541
GO:0005886TAS-plasma membrane-
GO:0008021IBA-synaptic vesicle-
GO:0009986IDA-cell surface15576373
GO:0016020IDA-membrane7690687
GO:0016021IBA-integral component of membrane-
GO:0016323IDA-basolateral plasma membrane16339081
GO:0030027IDA-lamellipodium21720706
GO:0030670TAS-phagocytic vesicle membrane-
GO:0031201IDA-SNARE complex12130530
GO:0035749IEA-myelin sheath adaxonal region-
GO:0036477IDA-somatodendritic compartment20434989
GO:0042581IDA-specific granule18588921
GO:0043197IDA-dendritic spine20434989
GO:0043219IEA-lateral loop-
GO:0045202IDA-synapse20434989
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0000149IBA-SNARE binding-
GO:0005484IBA-SNAP receptor activity-
GO:0005515IPI-protein binding12130530
GO:0016230IMP-sphingomyelin phosphodiesterase activator activity20956541
GO ID Evidence Qualifier GO_term References
GO:0006886IBA-intracellular protein transport-
GO:0006892TAS-post-Golgi vesicle-mediated transport-
GO:0008284IMP-positive regulation of cell proliferation21720706
GO:0017157IMP-regulation of exocytosis20434989
GO:0030335IMP-positive regulation of cell migration15351710
GO:0031629IBA-synaptic vesicle fusion to presynaptic active zone membrane-
GO:0033194IDA-response to hydroperoxide22226963
GO:0035493IEA-SNARE complex assembly-
GO:0035774IDA-positive regulation of insulin secretion involved in cellular response to glucose stimulus24552216
GO:0035774IMP-positive regulation of insulin secretion involved in cellular response to glucose stimulus12855681
GO:0043085IMP-positive regulation of catalytic activity20956541
GO:0043311IMP-positive regulation of eosinophil degranulation16677249
GO:0045785IMP-positive regulation of cell adhesion21720706
GO:0048278IBA-vesicle docking-
GO:0048284IDA-organelle fusion20434989
GO:0050921IMP-positive regulation of chemotaxis21720706
GO:0051024IMP-positive regulation of immunoglobulin secretion24055037
GO:0060291IDA-long-term synaptic potentiation20434989
GO:0090004IMP-positive regulation of establishment of protein localization to plasma membrane15351710
GO:1902041IMP-regulation of extrinsic apoptotic signaling pathway via death domain receptors20956541
GO:1903078IMP-positive regulation of protein localization to plasma membrane20956541
GO:1990668TAS-vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane-
GO:2000010IMP-positive regulation of protein localization to cell surface21720706
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STX4SEPT511267911880646 Affinity Capture-Western
STX4SEPT511141411880646 Affinity Capture-Western
STX4RAB4A11180511063739 Affinity Capture-Western; Reconstituted Complex
STX4RAB4A11267911063739 Affinity Capture-Western; Reconstituted Complex
STX4RAB5A11267911884531 Affinity Capture-Western
STX4RAB5A11180611884531 Affinity Capture-Western
STX4SNAP251126797768895 8663154 9852078 10194441 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STX4SNAP251125007768895 8663154 9852078 10194441 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
STXBP1STX41126797768895 12773094 Affinity Capture-Western; Reconstituted Complex
STXBP1STX41126817768895 12773094 Affinity Capture-Western; Reconstituted Complex
STXBP2STX41126797768895 Reconstituted Complex
STXBP2STX41126827768895 Reconstituted Complex
SNAP23STX41143038663154 9168999 9852078 10713150 10820264 12556468 12651853 12828989 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SNAP23STX41126798663154 9168999 9852078 10713150 10820264 12556468 12651853 12828989 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
VAMP2STX41126798760387 10194441 10820264 12517971 Affinity Capture-Western; Two-hybrid
VAMP2STX41127118760387 10194441 10820264 12517971 Affinity Capture-Western; Two-hybrid
VAMP1STX41126798760387 Two-hybrid
VAMP1STX41127108760387 Two-hybrid
SNAP29STX41147489852078 Reconstituted Complex
SNAP29STX41126799852078 Reconstituted Complex
SYT1STX411267910397765 Reconstituted Complex
SYT1STX411272310397765 Reconstituted Complex
VAMP8STX411267910820264 12130530 Affinity Capture-MS; Affinity Capture-Western
VAMP8STX411422110820264 12130530 Affinity Capture-MS; Affinity Capture-Western
VAMP3STX411474710820264 12130530 12828989 16189514 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
VAMP3STX411267910820264 12130530 12828989 16189514 Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
TXLNASTX412829712558796 Reconstituted Complex
TXLNASTX411267912558796 Reconstituted Complex
VAPBSTX411465012651853 Reconstituted Complex
VAPBSTX411267912651853 Reconstituted Complex
STXBP3STX411267912773094 12832401 Affinity Capture-Western; Two-hybrid
STXBP3STX411268312773094 12832401 Affinity Capture-Western; Two-hybrid
STXBP5STX412641712832401 Reconstituted Complex; Two-hybrid
STXBP5STX411267912832401 Reconstituted Complex; Two-hybrid
VAMP7STX411267912853575 Affinity Capture-Western
VAMP7STX411271212853575 Affinity Capture-Western
TXLNBSTX412795215184072 Reconstituted Complex
TXLNBSTX411267915184072 Reconstituted Complex
NAPASTX411267916189514 Affinity Capture-Western; Two-hybrid
NAPASTX411430516189514 Affinity Capture-Western; Two-hybrid
VAMP4STX411267916189514 Two-hybrid
VAMP4STX411422216189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:893577
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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