AutismKB 2.0

Annotation Details for STXBP1


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Basic Information Top
Gene Symbol:STXBP1 ( FLJ37475,MUNC18-1,NSEC1,P67,RBSEC1,UNC18 )
Gene Full Name: syntaxin binding protein 1
Band: 9q34.11
Quick LinksEntrez ID:6812; OMIM: 602926; Uniprot ID:STXB1_HUMAN; ENSEMBL ID: ENSG00000136854; HGNC ID: 11444
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005737ISS-cytoplasm-
GO:0005739ISS-mitochondrion-
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane12773094
GO:0005886ISScolocalizes_withplasma membrane-
GO:0031091IDA-platelet alpha granule12773094
GO:0043195IEA-terminal bouton-
GO:0043209IEA-myelin sheath-
GO:0043234ISS-protein complex-
GO:0048787IEA-presynaptic active zone membrane-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0000149ISS-SNARE binding-
GO:0003723IDA-RNA binding22658674
GO:0005515IPI-protein binding25416956
GO:0017075IPI-syntaxin-1 binding12730201
GO:0017075ISS-syntaxin-1 binding-
GO:0019901IEA-protein kinase binding-
GO:0019904IEA-protein domain specific binding-
GO:0019905IPI-syntaxin binding12773094
GO:0042802ISS-identical protein binding-
GO:0047485IEA-protein N-terminus binding-
GO ID Evidence Qualifier GO_term References
GO:0002576IMP-platelet degranulation12773094
GO:0006904ISS-vesicle docking involved in exocytosis-
GO:0007269TAS-neurotransmitter secretion-
GO:0007274IEA-neuromuscular synaptic transmission-
GO:0007412ISS-axon target recognition-
GO:0010807ISS-regulation of synaptic vesicle priming-
GO:0014047TAS-glutamate secretion-
GO:0015031IEA-protein transport-
GO:0016188ISS-synaptic vesicle maturation-
GO:0031333IEA-negative regulation of protein complex assembly-
GO:0031630TAS-regulation of synaptic vesicle fusion to presynaptic active zone membrane15217342
GO:0032229ISS-negative regulation of synaptic transmission, GABAergic-
GO:0035542TAS-regulation of SNARE complex assembly15217342
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045956IEA-positive regulation of calcium ion-dependent exocytosis-
GO:0050821IEA-protein stabilization-
GO:0060292IEA-long term synaptic depression-
GO:0070527IMP-platelet aggregation12773094
GO:0072659IDA-protein localization to plasma membrane17543282
GO:0099525IEA-presynaptic dense core vesicle exocytosis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
STXBP1CDK510745512963086 Affinity Capture-Western
STXBP1CDK511268112963086 Affinity Capture-Western
STXBP1STX21083687768895 12773094 Affinity Capture-Western; Reconstituted Complex
STXBP1STX21126817768895 12773094 Affinity Capture-Western; Reconstituted Complex
STXBP1MAPT11030812963086 Affinity Capture-Western
STXBP1MAPT11268112963086 Affinity Capture-Western
STXBP1STX1A1126767553862 7768895 10449403 12093152 12963086 Affinity Capture-Western; Reconstituted Complex
STXBP1STX1A1126817553862 7768895 10449403 12093152 12963086 Affinity Capture-Western; Reconstituted Complex
STXBP1STX31126787768895 Reconstituted Complex
STXBP1STX31126817768895 Reconstituted Complex
STXBP1STX41126797768895 12773094 Affinity Capture-Western; Reconstituted Complex
STXBP1STX41126817768895 12773094 Affinity Capture-Western; Reconstituted Complex
STX1BSTXBP111268112093152 Reconstituted Complex
STX1BSTXBP112520312093152 Reconstituted Complex
SYTL4STXBP112512012590134 Affinity Capture-Western
SYTL4STXBP111268112590134 Affinity Capture-Western
TUBA4ASTXBP111312812963086 Affinity Capture-Western
TUBA4ASTXBP111268112963086 Affinity Capture-Western
TUBB2ASTXBP111313112963086 Affinity Capture-Western
TUBB2ASTXBP111268112963086 Affinity Capture-Western
HGSSTXBP111268119019082 Reconstituted Complex
HGSSTXBP111459319019082 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:107363
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050626-106'