AutismKB 2.0

Annotation Details for ABCC8


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Basic Information Top
Gene Symbol:ABCC8 ( ABC36,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,TNDM2 )
Gene Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Band: 11p15.1
Quick LinksEntrez ID:6833; OMIM: 600509; Uniprot ID:ABCC8_HUMAN; ENSEMBL ID: ENSG00000006071; HGNC ID: 59
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005739IEA-mitochondrion-
GO:0005886TAS-plasma membrane-
GO:0008076IDA-voltage-gated potassium channel complex20610380
GO:0008282IBA-ATP-sensitive potassium channel complex-
GO:0030672IEA-synaptic vesicle membrane-
GO:0042383IBA-sarcolemma-
GO ID Evidence Qualifier GO_term References
GO:0005267IMP-potassium channel activity24814349
GO:0005524IEA-ATP binding-
GO:0008281IEA-sulfonylurea receptor activity-
GO:0015272TAS-ATP-activated inward rectifier potassium channel activity-
GO:0019905IEA-syntaxin binding-
GO:0042626IBA-ATPase activity, coupled to transmembrane movement of substances-
GO:0043225TAS-ATPase-coupled anion transmembrane transporter activity-
GO:0044325IPI-ion channel binding20610380
GO ID Evidence Qualifier GO_term References
GO:0001678IEA-cellular glucose homeostasis-
GO:0006813TAS-potassium ion transport7502040
GO:0007165IEA-signal transduction-
GO:0007565IEA-female pregnancy-
GO:0009268IEA-response to pH-
GO:0010043IEA-response to zinc ion-
GO:0010989IEA-negative regulation of low-density lipoprotein particle clearance-
GO:0032496IEA-response to lipopolysaccharide-
GO:0032868IEA-response to insulin-
GO:0042493IBA-response to drug-
GO:0046676IEA-negative regulation of insulin secretion-
GO:0050796TAS-regulation of insulin secretion-
GO:0055085TAS-transmembrane transport-
GO:0060253IEA-negative regulation of glial cell proliferation-
GO:0061855IEA-negative regulation of neuroblast migration-
GO:0071310IEA-cellular response to organic substance-
GO:0071805IEA-potassium ion transmembrane transport-
GO:0099133IEA-ATP hydrolysis coupled anion transmembrane transport-
GO:1900721IEA-positive regulation of uterine smooth muscle relaxation-
GO:1903818IEA-positive regulation of voltage-gated potassium channel activity-
GO:1904469IEA-positive regulation of tumor necrosis factor secretion-
GO:1905605IEA-positive regulation of maintenance of permeability of blood-brain barrier-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ABCC8KCNJ1111270012941953 Affinity Capture-Western
ABCC8KCNJ1110996912941953 Affinity Capture-Western
RAPGEF4ABCC811625314660679 Affinity Capture-Western
RAPGEF4ABCC811270014660679 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ABCC8rs1048099, rs1799854, rs1799857, rs1799858, rs2074308, rs4148628, rs4148646, rs757110, rs8192690, rs8192694, rs8192695 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1352629
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050517-22'