AutismKB 2.0

Annotation Details for VAMP2


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Basic Information Top
Gene Symbol:VAMP2 ( FLJ11460,SYB2,VAMP-2 )
Gene Full Name: vesicle-associated membrane protein 2 (synaptobrevin 2)
Band: 17p13.1
Quick LinksEntrez ID:6844; OMIM: 185881; Uniprot ID:VAMP2_HUMAN; ENSEMBL ID: ENSG00000220205; HGNC ID: 12643
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005802ISS-trans-Golgi network-
GO:0005829TAS-cytosol-
GO:0005886ISS-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005887TAS-integral component of plasma membrane1976629
GO:0008021ISS-synaptic vesicle-
GO:0008021TAS-synaptic vesicle10099709
GO:0008076ISScolocalizes_withvoltage-gated potassium channel complex-
GO:0016020IDA-membrane16677249
GO:0030054IEA-cell junction-
GO:0030136IDA-clathrin-coated vesicle19478182
GO:0030141ISS-secretory granule-
GO:0030665TAS-clathrin-coated vesicle membrane-
GO:0030667IDANOTsecretory granule membrane16677249
GO:0030667TAS-secretory granule membrane-
GO:0030672ISS-synaptic vesicle membrane-
GO:0030672TAS-synaptic vesicle membrane-
GO:0031201IDA-SNARE complex12130530
GO:0031201TAS-SNARE complex10099709
GO:0031410ISS-cytoplasmic vesicle-
GO:0031982IDA-vesicle17313651
GO:0042589ISS-zymogen granule membrane-
GO:0043005ISS-neuron projection-
GO:0043231ISS-intracellular membrane-bounded organelle-
GO:0044306ISS-neuron projection terminus-
GO:0045202ISS-synapse-
GO:0048471ISS-perinuclear region of cytoplasm-
GO:0060203TAS-clathrin-sculpted glutamate transport vesicle membrane-
GO:0061202TAS-clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane-
GO:0070032ISS-synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex-
GO:0070033ISS-synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex-
GO:0070044ISS-synaptobrevin 2-SNAP-25-syntaxin-1a complex-
GO:0070062IDA-extracellular exosome23376485
GO:0070083TAS-clathrin-sculpted monoamine transport vesicle membrane-
GO ID Evidence Qualifier GO_term References
GO:0000149ISS-SNARE binding-
GO:0005484IBA-SNAP receptor activity-
GO:0005515IPI-protein binding9920726
GO:0005516ISS-calmodulin binding-
GO:0005543ISS-phospholipid binding-
GO:0017075ISS-syntaxin-1 binding-
GO:0019905IPI-syntaxin binding12855681
GO:0019905ISS-syntaxin binding-
GO:0043621TAS-protein self-association15217342
GO:0048306ISS-calcium-dependent protein binding-
GO ID Evidence Qualifier GO_term References
GO:0006461ISS-protein complex assembly-
GO:0006887TAS-exocytosis10099709
GO:0006892TAS-post-Golgi vesicle-mediated transport-
GO:0006906IBA-vesicle fusion-
GO:0007269TAS-neurotransmitter secretion-
GO:0009749ISS-response to glucose-
GO:0014047TAS-glutamate secretion-
GO:0015031ISS-protein transport-
GO:0016079ISS-synaptic vesicle exocytosis-
GO:0016079TAS-synaptic vesicle exocytosis15217342
GO:0016192ISS-vesicle-mediated transport-
GO:0017156ISS-calcium ion regulated exocytosis-
GO:0017157ISS-regulation of exocytosis-
GO:0032869ISS-cellular response to insulin stimulus-
GO:0043001ISS-Golgi to plasma membrane protein transport-
GO:0043308IMP-eosinophil degranulation16677249
GO:0043312IMPNOTneutrophil degranulation16677249
GO:0043320IMPNOTnatural killer cell degranulation18042464
GO:0060291ISS-long-term synaptic potentiation-
GO:0060627ISS-regulation of vesicle-mediated transport-
GO:0061024TAS-membrane organization-
GO:0061025ISS-membrane fusion-
GO:0070254IMPNOTmucus secretion22144578
GO:0090316ISS-positive regulation of intracellular protein transport-
GO:1902259ISS-regulation of delayed rectifier potassium channel activity-
GO:1903593IMPNOTregulation of histamine secretion by mast cell18253931
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
VAMP2STX210836812828989 Two-hybrid
VAMP2STX211271112828989 Two-hybrid
VAMP2SNAP251125009030619 11524423 11832227 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
VAMP2SNAP251127119030619 11524423 11832227 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
VAMP2STX1A1126767553862 9030619 10100611 10449403 11832227 12093152 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
VAMP2STX1A1127117553862 9030619 10100611 10449403 11832227 12093152 Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybrid
VAMP2STX311267812828989 Two-hybrid
VAMP2STX311271112828989 Two-hybrid
VAMP2STX41126798760387 10194441 10820264 12517971 Affinity Capture-Western; Two-hybrid
VAMP2STX41127118760387 10194441 10820264 12517971 Affinity Capture-Western; Two-hybrid
VAMP2STXBP311268312832401 Reconstituted Complex
VAMP2STXBP311271112832401 Reconstituted Complex
NAPAVAMP21143057622514 Reconstituted Complex
NAPAVAMP21127117622514 Reconstituted Complex
UNC13BVAMP21157598999968 Co-fractionation
UNC13BVAMP21127118999968 Co-fractionation
RABAC1VAMP21158189341137 Reconstituted Complex; Two-hybrid
RABAC1VAMP21127119341137 Reconstituted Complex; Two-hybrid
BCAP31VAMP21154379396746 Reconstituted Complex
BCAP31VAMP21127119396746 Reconstituted Complex
VAPAVAMP21146519657962 Reconstituted Complex
VAPAVAMP21127119657962 Reconstituted Complex
VAPBVAMP21146509920726 Reconstituted Complex
VAPBVAMP21127119920726 Reconstituted Complex
STX11VAMP211422410036234 Reconstituted Complex
STX11VAMP211271110036234 Reconstituted Complex
SNAP23VAMP211430310713150 10820264 12828989 Affinity Capture-Western; Reconstituted Complex
SNAP23VAMP211271110713150 10820264 12828989 Affinity Capture-Western; Reconstituted Complex
CPLX1VAMP211602811832227 Co-crystal Structure
CPLX1VAMP211271111832227 Co-crystal Structure
STX1BVAMP212520312093152 Two-hybrid
STX1BVAMP211271112093152 Two-hybrid
VAMP8VAMP211422112130530 Reconstituted Complex
VAMP8VAMP211271112130530 Reconstituted Complex
VAMP3VAMP211474712130530 Reconstituted Complex
VAMP3VAMP211271112130530 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
VAMP2rs1061032, rs2278637, rs8067606 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1313277
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-8225'