AutismKB 2.0

Annotation Details for SYT1


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Basic Information Top
Gene Symbol:SYT1 ( DKFZp781D2042,P65,SVP65,SYT )
Gene Full Name: synaptotagmin I
Band: 12q21.2
Quick LinksEntrez ID:6857; OMIM: 185605; Uniprot ID:SYT1_HUMAN; ENSEMBL ID: ENSG00000067715; HGNC ID: 11509
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005794IEA-Golgi apparatus-
GO:0005886IBA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0008021TAS-synaptic vesicle11438518
GO:0030054IEA-cell junction-
GO:0030285IEA-integral component of synaptic vesicle membrane-
GO:0030665TAS-clathrin-coated vesicle membrane-
GO:0030672IBA-synaptic vesicle membrane-
GO:0030672TAS-synaptic vesicle membrane-
GO:0031045IEA-dense core granule-
GO:0031201IEA-SNARE complex-
GO:0042584IEA-chromaffin granule membrane-
GO:0042734IEA-presynaptic membrane-
GO:0043005ISS-neuron projection-
GO:0043195IEA-terminal bouton-
GO:0060076IEA-excitatory synapse-
GO:0060201TAS-clathrin-sculpted acetylcholine transport vesicle membrane-
GO:0060203TAS-clathrin-sculpted glutamate transport vesicle membrane-
GO:0061202TAS-clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane-
GO:0070083TAS-clathrin-sculpted monoamine transport vesicle membrane-
GO ID Evidence Qualifier GO_term References
GO:0000149ISS-SNARE binding-
GO:0001786IEA-phosphatidylserine binding-
GO:0005509IBA-calcium ion binding-
GO:0005515IPI-protein binding11438518
GO:0005516IEA-calmodulin binding-
GO:0005544ISS-calcium-dependent phospholipid binding-
GO:0005544TAS-calcium-dependent phospholipid binding12526776
GO:0005545TAS-1-phosphatidylinositol binding11438518
GO:0005546IBA-phosphatidylinositol-4,5-bisphosphate binding-
GO:0008022IEA-protein C-terminus binding-
GO:0017075ISS-syntaxin-1 binding-
GO:0017075TAS-syntaxin-1 binding11438518
GO:0030276IBA-clathrin binding-
GO:0030348IEA-syntaxin-3 binding-
GO:0042802IEA-identical protein binding-
GO:0046982IEA-protein heterodimerization activity-
GO:0048306IEA-calcium-dependent protein binding-
GO:0050750IDA-low-density lipoprotein particle receptor binding15082773
GO ID Evidence Qualifier GO_term References
GO:0005513TAS-detection of calcium ion11438518
GO:0006906IBA-vesicle fusion-
GO:0007268TAS-chemical synaptic transmission1840599
GO:0007269TAS-neurotransmitter secretion11438518
GO:0007420IEA-brain development-
GO:0014047TAS-glutamate secretion-
GO:0014059IEA-regulation of dopamine secretion-
GO:0017157TAS-regulation of exocytosis11438518
GO:0017158IBA-regulation of calcium ion-dependent exocytosis-
GO:0031340IEA-positive regulation of vesicle fusion-
GO:0045956IEA-positive regulation of calcium ion-dependent exocytosis-
GO:0048278IEA-vesicle docking-
GO:0048488IBA-synaptic vesicle endocytosis-
GO:0048791IBA-calcium ion-regulated exocytosis of neurotransmitter-
GO:0050806ISS-positive regulation of synaptic transmission-
GO:0051260TAS-protein homooligomerization11438518
GO:0051291IEA-protein heterooligomerization-
GO:0051966ISS-regulation of synaptic transmission, glutamatergic-
GO:0061024TAS-membrane organization-
GO:0071277ISS-cellular response to calcium ion-
GO:0098746ISS-fast, calcium ion-dependent exocytosis of neurotransmitter-
GO:1903305ISS-regulation of regulated secretory pathway-
GO:1903861IDA-positive regulation of dendrite extension23999003
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
SYT1CACNA1A1072279303303 Reconstituted Complex
SYT1CACNA1A1127239303303 Reconstituted Complex
SYT1CALM11072528901523 Reconstituted Complex
SYT1CALM11127238901523 Reconstituted Complex
SYT1STX210836810397765 Reconstituted Complex
SYT1STX211272310397765 Reconstituted Complex
SYT1FGF110853711432880 Reconstituted Complex
SYT1FGF111272311432880 Reconstituted Complex
SYT1S100A131121929712836 11432880 Co-purification; Reconstituted Complex
SYT1S100A131127239712836 11432880 Co-purification; Reconstituted Complex
SYT1SNAP2511250010692432 12062043 Reconstituted Complex
SYT1SNAP2511272310692432 12062043 Reconstituted Complex
SYT1STX1A1126769010211 10397765 Reconstituted Complex
SYT1STX1A1127239010211 10397765 Reconstituted Complex
SYT1STX311267810397765 Reconstituted Complex
SYT1STX311272310397765 Reconstituted Complex
SYT1STX411267910397765 Reconstituted Complex
SYT1STX411272310397765 Reconstituted Complex
SYNCRIPSYT111575510734137 Reconstituted Complex
SYNCRIPSYT111272310734137 Reconstituted Complex
STON2SYT112452611381094 11454741 Reconstituted Complex
STON2SYT111272311381094 11454741 Reconstituted Complex
SV2CSYT111663615466855 Affinity Capture-Western
SV2CSYT111272315466855 Affinity Capture-Western
C6orf15SYT111887915466855 Affinity Capture-Western
C6orf15SYT111272315466855 Affinity Capture-Western
SV2BSYT111522815466855 Affinity Capture-Western
SV2BSYT111272315466855 Affinity Capture-Western
SIN3ASYT111743915467731 Reconstituted Complex; Two-hybrid
SIN3ASYT111272315467731 Reconstituted Complex; Two-hybrid
RBM14SYT111570015919756 Reconstituted Complex
RBM14SYT111272315919756 Reconstituted Complex
GOLM1SYT111943216169070 Two-hybrid
GOLM1SYT111272316169070 Two-hybrid
IKBKGSYT111408920098747 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IKBKGSYT111272320098747 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
ZDHHC17SYT119570915603740 HIP14 catalyzes palmitoylation of Synaptotagmin I. This interaction was modeled on a demonstrated interaction between human HIP14 and Synaptotagmin I from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:99667
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040718-165'