AutismKB 2.0

Annotation Details for ADAM17


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Basic Information Top
Gene Symbol:ADAM17 ( ADAM18,CD156B,CSVP,MGC71942,TACE )
Gene Full Name: ADAM metallopeptidase domain 17
Band: 2p25.1
Quick LinksEntrez ID:6868; OMIM: 603639; Uniprot ID:ADA17_HUMAN; ENSEMBL ID: ENSG00000151694; HGNC ID: 195
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm25468996
GO:0005829IDA-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane17786981
GO:0005911IDAcolocalizes_withcell-cell junction14970227
GO:0005925IDAcolocalizes_withfocal adhesion14970227
GO:0009986IDA-cell surface9034190
GO:0015629IDA-actin cytoskeleton17010968
GO:0016020IDA-membrane19946888
GO:0016324IDA-apical plasma membrane16034137
GO:0032587IDAcolocalizes_withruffle membrane14970227
GO:0045121IDA-membrane raft17010968
GO ID Evidence Qualifier GO_term References
GO:0004222IDA-metalloendopeptidase activity9920899
GO:0004222IMP-metalloendopeptidase activity9034190
GO:0004222TAS-metalloendopeptidase activity-
GO:0005112IDA-Notch binding24226769
GO:0005138IPI-interleukin-6 receptor binding16034137
GO:0005178IPI-integrin binding14970227
GO:0005515IPI-protein binding10527948
GO:0008237IDA-metallopeptidase activity12777399
GO:0008237IMP-metallopeptidase activity12535668
GO:0008237TAS-metallopeptidase activity-
GO:0017124IEA-SH3 domain binding-
GO:0030165IPI-PDZ domain binding12207026
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0001666IDA-response to hypoxia18276953
GO:0001934IMP-positive regulation of protein phosphorylation18625725
GO:0002446IC-neutrophil mediated immunity16034137
GO:0002467ISS-germinal center formation10433800
GO:0002690IC-positive regulation of leukocyte chemotaxis16034137
GO:0006508IDA-proteolysis24227843
GO:0006509IDA-membrane protein ectodomain proteolysis9034190
GO:0006509IMP-membrane protein ectodomain proteolysis9034191
GO:0007155IDA-cell adhesion14970227
GO:0007173IDA-epidermal growth factor receptor signaling pathway12743035
GO:0007219IEA-Notch signaling pathway-
GO:0007220IDA-Notch receptor processing24226769
GO:0008284IMP-positive regulation of cell proliferation18373975
GO:0010820IMP-positive regulation of T cell chemotaxis18373975
GO:0030183ISS-B cell differentiation10433800
GO:0030307IMP-positive regulation of cell growth18373975
GO:0030335IMP-positive regulation of cell migration18373975
GO:0030511ISS-positive regulation of transforming growth factor beta receptor signaling pathway10433800
GO:0030512IMP-negative regulation of transforming growth factor beta receptor signaling pathway21170088
GO:0031293TAS-membrane protein intracellular domain proteolysis-
GO:0031659IDA-positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle18483258
GO:0032496IDA-response to lipopolysaccharide18383040
GO:0032722IMP-positive regulation of chemokine production16034137
GO:0033025ISS-regulation of mast cell apoptotic process10433800
GO:0033077ISS-T cell differentiation in thymus10433800
GO:0033209TAS-tumor necrosis factor-mediated signaling pathway-
GO:0033627IDA-cell adhesion mediated by integrin14970227
GO:0035313IEP-wound healing, spreading of epidermal cells14970227
GO:0035625IMP-epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway17655843
GO:0042493ISS-response to drug10433800
GO:0045741IDA-positive regulation of epidermal growth factor-activated receptor activity18483258
GO:0045741IMP-positive regulation of epidermal growth factor-activated receptor activity17655843
GO:0048536ISS-spleen development10433800
GO:0048870ISS-cell motility10433800
GO:0050830IMP-defense response to Gram-positive bacterium16034137
GO:0051088IDA-PMA-inducible membrane protein ectodomain proteolysis14625290
GO:0051088IMP-PMA-inducible membrane protein ectodomain proteolysis18676862
GO:0051272ISS-positive regulation of cellular component movement10433800
GO:0055099IDA-response to high density lipoprotein particle17786981
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ADAM17DLG111273112668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17DLG110808312668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111273110527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111026010527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAPK111273112058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ADAM17MAPK111158012058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TIMP3ADAM1711273112044879 Reconstituted Complex
TIMP3ADAM1711293412044879 Reconstituted Complex
Gene Symbol Interactant Interaction ID References Description
SH3D19ADAM1718305515280379 An unspecified isoform of ADAM17 binds to Eve-1d.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADAM17ADAM17_154C/A, rs11684747, rs11689958, rs12474969, rs12692386, rs1524668 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1096335
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2862'