Annotation Details for ADAM17
Basic Information Top
Gene Symbol: | ADAM17 ( ADAM18,CD156B,CSVP,MGC71942,TACE ) |
---|---|
Gene Full Name: | ADAM metallopeptidase domain 17 |
Band: | 2p25.1 |
Quick Links | Entrez ID:6868; OMIM: 603639; Uniprot ID:ADA17_HUMAN; ENSEMBL ID: ENSG00000151694; HGNC ID: 195 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0005737 | IDA | - | cytoplasm | 25468996 |
GO:0005829 | IDA | - | cytosol | - |
GO:0005886 | TAS | - | plasma membrane | - |
GO:0005887 | IDA | - | integral component of plasma membrane | 17786981 |
GO:0005911 | IDA | colocalizes_with | cell-cell junction | 14970227 |
GO:0005925 | IDA | colocalizes_with | focal adhesion | 14970227 |
GO:0009986 | IDA | - | cell surface | 9034190 |
GO:0015629 | IDA | - | actin cytoskeleton | 17010968 |
GO:0016020 | IDA | - | membrane | 19946888 |
GO:0016324 | IDA | - | apical plasma membrane | 16034137 |
GO:0032587 | IDA | colocalizes_with | ruffle membrane | 14970227 |
GO:0045121 | IDA | - | membrane raft | 17010968 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0004222 | IDA | - | metalloendopeptidase activity | 9920899 |
GO:0004222 | IMP | - | metalloendopeptidase activity | 9034190 |
GO:0004222 | TAS | - | metalloendopeptidase activity | - |
GO:0005112 | IDA | - | Notch binding | 24226769 |
GO:0005138 | IPI | - | interleukin-6 receptor binding | 16034137 |
GO:0005178 | IPI | - | integrin binding | 14970227 |
GO:0005515 | IPI | - | protein binding | 10527948 |
GO:0008237 | IDA | - | metallopeptidase activity | 12777399 |
GO:0008237 | IMP | - | metallopeptidase activity | 12535668 |
GO:0008237 | TAS | - | metallopeptidase activity | - |
GO:0017124 | IEA | - | SH3 domain binding | - |
GO:0030165 | IPI | - | PDZ domain binding | 12207026 |
GO:0046872 | IEA | - | metal ion binding | - |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0001666 | IDA | - | response to hypoxia | 18276953 |
GO:0001934 | IMP | - | positive regulation of protein phosphorylation | 18625725 |
GO:0002446 | IC | - | neutrophil mediated immunity | 16034137 |
GO:0002467 | ISS | - | germinal center formation | 10433800 |
GO:0002690 | IC | - | positive regulation of leukocyte chemotaxis | 16034137 |
GO:0006508 | IDA | - | proteolysis | 24227843 |
GO:0006509 | IDA | - | membrane protein ectodomain proteolysis | 9034190 |
GO:0006509 | IMP | - | membrane protein ectodomain proteolysis | 9034191 |
GO:0007155 | IDA | - | cell adhesion | 14970227 |
GO:0007173 | IDA | - | epidermal growth factor receptor signaling pathway | 12743035 |
GO:0007219 | IEA | - | Notch signaling pathway | - |
GO:0007220 | IDA | - | Notch receptor processing | 24226769 |
GO:0008284 | IMP | - | positive regulation of cell proliferation | 18373975 |
GO:0010820 | IMP | - | positive regulation of T cell chemotaxis | 18373975 |
GO:0030183 | ISS | - | B cell differentiation | 10433800 |
GO:0030307 | IMP | - | positive regulation of cell growth | 18373975 |
GO:0030335 | IMP | - | positive regulation of cell migration | 18373975 |
GO:0030511 | ISS | - | positive regulation of transforming growth factor beta receptor signaling pathway | 10433800 |
GO:0030512 | IMP | - | negative regulation of transforming growth factor beta receptor signaling pathway | 21170088 |
GO:0031293 | TAS | - | membrane protein intracellular domain proteolysis | - |
GO:0031659 | IDA | - | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 18483258 |
GO:0032496 | IDA | - | response to lipopolysaccharide | 18383040 |
GO:0032722 | IMP | - | positive regulation of chemokine production | 16034137 |
GO:0033025 | ISS | - | regulation of mast cell apoptotic process | 10433800 |
GO:0033077 | ISS | - | T cell differentiation in thymus | 10433800 |
GO:0033209 | TAS | - | tumor necrosis factor-mediated signaling pathway | - |
GO:0033627 | IDA | - | cell adhesion mediated by integrin | 14970227 |
GO:0035313 | IEP | - | wound healing, spreading of epidermal cells | 14970227 |
GO:0035625 | IMP | - | epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 17655843 |
GO:0042493 | ISS | - | response to drug | 10433800 |
GO:0045741 | IDA | - | positive regulation of epidermal growth factor-activated receptor activity | 18483258 |
GO:0045741 | IMP | - | positive regulation of epidermal growth factor-activated receptor activity | 17655843 |
GO:0048536 | ISS | - | spleen development | 10433800 |
GO:0048870 | ISS | - | cell motility | 10433800 |
GO:0050830 | IMP | - | defense response to Gram-positive bacterium | 16034137 |
GO:0051088 | IDA | - | PMA-inducible membrane protein ectodomain proteolysis | 14625290 |
GO:0051088 | IMP | - | PMA-inducible membrane protein ectodomain proteolysis | 18676862 |
GO:0051272 | ISS | - | positive regulation of cellular component movement | 10433800 |
GO:0055099 | IDA | - | response to high density lipoprotein particle | 17786981 |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
ADAM17 | DLG1 | 112731 | 12668732 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
ADAM17 | DLG1 | 108083 | 12668732 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
ADAM17 | MAD2L1 | 112731 | 10527948 11741929 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
ADAM17 | MAD2L1 | 110260 | 10527948 11741929 | Affinity Capture-Western; Reconstituted Complex; Two-hybrid |
ADAM17 | MAPK1 | 112731 | 12058067 | Affinity Capture-Western; Biochemical Activity; Reconstituted Complex |
ADAM17 | MAPK1 | 111580 | 12058067 | Affinity Capture-Western; Biochemical Activity; Reconstituted Complex |
TIMP3 | ADAM17 | 112731 | 12044879 | Reconstituted Complex |
TIMP3 | ADAM17 | 112934 | 12044879 | Reconstituted Complex |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
SH3D19 | ADAM17 | 183055 | 15280379 | An unspecified isoform of ADAM17 binds to Eve-1d. |
No data |
Gene Symbol | Poly Names | Gene overview in AlzGene |
---|---|---|
ADAM17 | ADAM17_154C/A, rs11684747, rs11689958, rs12474969, rs12692386, rs1524668 | Gene overview in AlzGene |
No data |
No data |
- MGI ID: MGI:1096335
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-030131-2862