AutismKB 2.0

Annotation Details for ADAM17


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Basic Information Top
Gene Symbol:ADAM17 ( ADAM18,CD156B,CSVP,MGC71942,TACE )
Gene Full Name: ADAM metallopeptidase domain 17
Band: 2p25.1
Quick LinksEntrez ID:6868; OMIM: 603639; Uniprot ID:ADA17_HUMAN; ENSEMBL ID: ENSG00000151694; HGNC ID: 195
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm25468996
GO:0005829IDA-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane17786981
GO:0005911IDAcolocalizes_withcell-cell junction14970227
GO:0005925IDAcolocalizes_withfocal adhesion14970227
GO:0009986IDA-cell surface9034190
GO:0015629IDA-actin cytoskeleton17010968
GO:0016020IDA-membrane19946888
GO:0016324IDA-apical plasma membrane16034137
GO:0032587IDAcolocalizes_withruffle membrane14970227
GO:0045121IDA-membrane raft17010968
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ADAM17DLG111273112668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17DLG110808312668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111273110527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAD2L111026010527948 11741929 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17MAPK111273112058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
ADAM17MAPK111158012058067 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
TIMP3ADAM1711273112044879 Reconstituted Complex
TIMP3ADAM1711293412044879 Reconstituted Complex
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADAM17ADAM17_154C/A, rs11684747, rs11689958, rs12474969, rs12692386, rs1524668 Gene overview in AlzGene
Animal Model Top
  • MGI ID: MGI:1096335
  • Data Attributes: MGI curated and HomoloGene calculated