AutismKB 2.0

Annotation Details for MAP3K7


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP3K7 ( MEKK7,TAK1,TGF1a )
Gene Full Name: mitogen-activated protein kinase kinase kinase 7
Band: 6q15
Quick LinksEntrez ID:6885; OMIM: 602614; Uniprot ID:M3K7_HUMAN; ENSEMBL ID: ENSG00000135341; HGNC ID: 6859
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus21630459
GO:0005671IDA-Ada2/Gcn5/Ada3 transcription activator complex18838386
GO:0005829TAS-cytosol-
GO:0005886IEA-plasma membrane-
GO:0008385IPIcolocalizes_withIkappaB kinase complex10094049
GO:0010008TAS-endosome membrane-
GO ID Evidence Qualifier GO_term References
GO:0000287IEA-magnesium ion binding-
GO:0004672IDA-protein kinase activity10094049
GO:0004674EXP-protein serine/threonine kinase activity10702308
GO:0004674TAS-protein serine/threonine kinase activity-
GO:0004709EXP-MAP kinase kinase kinase activity11460167
GO:0004709IDA-MAP kinase kinase kinase activity11460167
GO:0005515IPI-protein binding10094049
GO:0005524IEA-ATP binding-
GO:0042802IPI-identical protein binding27426733
GO:0097110IDA-scaffold protein binding23776175
GO ID Evidence Qualifier GO_term References
GO:0000186IDA-activation of MAPKK activity8663074
GO:0000187IDA-activation of MAPK activity9079627
GO:0000187TAS-activation of MAPK activity-
GO:0002223TAS-stimulatory C-type lectin receptor signaling pathway-
GO:0002726IMP-positive regulation of T cell cytokine production15125833
GO:0002755TAS-MyD88-dependent toll-like receptor signaling pathway-
GO:0006351IEA-transcription, DNA-templated-
GO:0007179TAS-transforming growth factor beta receptor signaling pathway9466656
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0007249TAS-I-kappaB kinase/NF-kappaB signaling-
GO:0007250IMP-activation of NF-kappaB-inducing kinase activity10094049
GO:0007252IDA-I-kappaB phosphorylation11460167
GO:0007254IDA-JNK cascade9079627
GO:0007254TAS-JNK cascade-
GO:0016239ISS-positive regulation of macroautophagy-
GO:0016579TAS-protein deubiquitination-
GO:0032743IMP-positive regulation of interleukin-2 production15125833
GO:0038095TAS-Fc-epsilon receptor signaling pathway-
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling14982987
GO:0043276ISS-anoikis-
GO:0043507IDA-positive regulation of JUN kinase activity11460167
GO:0043507IMP-positive regulation of JUN kinase activity10094049
GO:0043966IDA-histone H3 acetylation18838386
GO:0050852NAS-T cell receptor signaling pathway15125833
GO:0050852TAS-T cell receptor signaling pathway-
GO:0050870IC-positive regulation of T cell activation15125833
GO:0051092TAS-positive regulation of NF-kappaB transcription factor activity-
GO:0051403IDA-stress-activated MAPK cascade9079627
GO:0070423TAS-nucleotide-binding oligomerization domain containing signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MAP3K7XIAP10682812048196 Affinity Capture-Western
MAP3K7XIAP11274812048196 Affinity Capture-Western
MAP3K7CHUK10756910094049 10187861 Affinity Capture-Western
MAP3K7CHUK11274810094049 10187861 Affinity Capture-Western
MAP3K7CYLD10792018332137 Affinity Capture-Western
MAP3K7CYLD11274818332137 Affinity Capture-Western
MAP3K7IKBKB10976710807933 Affinity Capture-Western
MAP3K7IKBKB11274810807933 Affinity Capture-Western
MAP3K7SMAD611026610748100 11737269 Affinity Capture-Western
MAP3K7SMAD611274810748100 11737269 Affinity Capture-Western
MAP3K7SMAD711026712589052 Affinity Capture-Western
MAP3K7SMAD711274812589052 Affinity Capture-Western
MAP3K7MAP3K511038110921914 Affinity Capture-Western; Two-hybrid
MAP3K7MAP3K511274810921914 Affinity Capture-Western; Two-hybrid
MAP3K7MYD8811274811544529 Phenotypic Suppression
MAP3K7MYD8811070011544529 Phenotypic Suppression
MAP3K7PPM1B11149011104763 Affinity Capture-Western; Reconstituted Complex
MAP3K7PPM1B11274811104763 Affinity Capture-Western; Reconstituted Complex
MAP3K7MAP2K611274810094049 10838074 11460167 14633987 Biochemical Activity
MAP3K7MAP2K611159410094049 10838074 11460167 14633987 Biochemical Activity
MAP3K7MAP3K71127489556573 Reconstituted Complex
TRAF6MAP3K711274810094049 10882101 10921914 11259596 14633987 16543409 18758450 19112497 Affinity Capture-Western
TRAF6MAP3K711304110094049 10882101 10921914 11259596 14633987 16543409 18758450 19112497 Affinity Capture-Western
IKBKAPMAP3K711409010094049 Affinity Capture-Western
IKBKAPMAP3K711274810094049 Affinity Capture-Western
MAP3K14MAP3K711274810094049 Affinity Capture-Western
MAP3K14MAP3K711448710094049 Affinity Capture-Western
TAB1MAP3K711571710094049 10838074 12975377 14670075 Affinity Capture-Western; Phenotypic Enhancement
TAB1MAP3K711274810094049 10838074 12975377 14670075 Affinity Capture-Western; Phenotypic Enhancement
MAP4K1MAP3K711274810224067 Affinity Capture-Western
MAP4K1MAP3K711635410224067 Affinity Capture-Western
MAP4K4MAP3K711483810807933 Affinity Capture-Western
MAP4K4MAP3K711274810807933 Affinity Capture-Western
TAB2MAP3K711674010882101 11259596 14633987 14670075 Affinity Capture-Western; Two-hybrid
TAB2MAP3K711274810882101 11259596 14633987 14670075 Affinity Capture-Western; Two-hybrid
HGSMAP3K711274811397816 Reconstituted Complex
HGSMAP3K711459311397816 Reconstituted Complex
TIRAPMAP3K712532511544529 Phenotypic Suppression
TIRAPMAP3K711274811544529 Phenotypic Suppression
TNFRSF11AMAP3K711274811809792 Affinity Capture-Western
TNFRSF11AMAP3K711432011809792 Affinity Capture-Western
STRADBMAP3K711274812048196 Affinity Capture-Western
STRADBMAP3K712066812048196 Affinity Capture-Western
TAB3MAP3K711274814633987 14670075 Affinity Capture-Western
TAB3MAP3K712921614633987 14670075 Affinity Capture-Western
TRAF2MAP3K711274814633987 Affinity Capture-Western
TRAF2MAP3K711303814633987 Affinity Capture-Western
HIPK2MAP3K711881515082531 Biochemical Activity
HIPK2MAP3K711274815082531 Biochemical Activity
RIPK1MAP3K711274816543241 18570872 Affinity Capture-Western
RIPK1MAP3K711427416543241 18570872 Affinity Capture-Western
SOCS3MAP3K711448816543409 Affinity Capture-Western
SOCS3MAP3K711274816543409 Affinity Capture-Western
PELI3MAP3K711274818326498 Affinity Capture-Western
PELI3MAP3K712890018326498 Affinity Capture-Western
TGFBR1MAP3K711274818758450 Affinity Capture-Western
TGFBR1MAP3K711290418758450 Affinity Capture-Western
COPS5MAP3K711618320936779 Two-hybrid
COPS5MAP3K711274820936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
TAB1MAP3K72083349878061 An unspecified isoform of TAK1 interacts with TAB1. This interaction was modeled on a demonstrated interaction between TAK1 from an unspecified species and human TAB1.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346877
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-041001-135'