AutismKB 2.0

Annotation Details for TCF4


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Basic Information Top
Gene Symbol:TCF4 ( E2-2,ITF2,MGC149723,MGC149724,PTHS,SEF2,SEF2-1,SEF2-1A,SEF2-1B,bHLHb19 )
Gene Full Name: transcription factor 4
Band: 18q21.2
Quick LinksEntrez ID:6925; OMIM: 602272; Uniprot ID:ITF2_HUMAN; ENSEMBL ID: ENSG00000196628; HGNC ID: 11634
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin21880741
GO:0005634IDA-nucleus1681116
GO:0005667IBA-transcription factor complex-
GO:0005667ISS-transcription factor complex8978694
GO:0032993IDA-protein-DNA complex12651860
GO ID Evidence Qualifier GO_term References
GO:0000978IBA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding12651860
GO:0000978ISS-RNA polymerase II core promoter proximal region sequence-specific DNA binding8978694
GO:0001011ISS-transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting8978694
GO:0001077ISS-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding8978694
GO:0001087ISS-transcription factor activity, TFIIB-class binding8978694
GO:0001093ISS-TFIIB-class transcription factor binding8978694
GO:0003677IDA-DNA binding1681116
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding2105528
GO:0005515IPI-protein binding10903890
GO:0008022IPI-protein C-terminus binding10903890
GO:0042802IPI-identical protein binding10903890
GO:0042803IBA-protein homodimerization activity-
GO:0043425IBA-bHLH transcription factor binding-
GO:0046982IBA-protein heterodimerization activity-
GO:0046982ISS-protein heterodimerization activity-
GO:0046982NAS-protein heterodimerization activity2105528
GO:0070888ISS-E-box binding8978694
GO ID Evidence Qualifier GO_term References
GO:0006352ISS-DNA-templated transcription, initiation8978694
GO:0006367ISS-transcription initiation from RNA polymerase II promoter8978694
GO:0045666IBA-positive regulation of neuron differentiation-
GO:0045666ISS-positive regulation of neuron differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated2105528
GO:0045944IBA-positive regulation of transcription from RNA polymerase II promoter-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter8978694
GO:0065004ISS-protein-DNA complex assembly8978694
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TCF4AR11278712799378 Affinity Capture-Western; Reconstituted Complex
TCF4AR10686212799378 Affinity Capture-Western; Reconstituted Complex
TCF4ASCL111278710903890 Reconstituted Complex; Two-hybrid
TCF4ASCL110692110903890 Reconstituted Complex; Two-hybrid
TCF4CALM111278710757985 Reconstituted Complex
TCF4CALM110725210757985 Reconstituted Complex
TCF4CTBP111278720211142 Two-hybrid
TCF4CTBP110786920211142 Two-hybrid
TCF4CTNNB111278711713475 11713476 12657632 15331612 17412698 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
TCF4CTNNB110788011713475 11713476 12657632 15331612 17412698 Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
TCF4DAXX11278720211142 Two-hybrid
TCF4DAXX10798520211142 Two-hybrid
TCF4ID11127879242638 9584154 Two-hybrid
TCF4ID11096239242638 9584154 Two-hybrid
TCF4ID21127878576241 9242638 9584154 Two-hybrid
TCF4ID21096248576241 9242638 9584154 Two-hybrid
TCF4ID31127878999959 9242638 Reconstituted Complex; Two-hybrid
TCF4ID31096258999959 9242638 Reconstituted Complex; Two-hybrid
TCF4LYL11127879242638 Two-hybrid
TCF4LYL11102449242638 Two-hybrid
TCF4MEN111278719074834 Affinity Capture-Western; Reconstituted Complex
TCF4MEN111038419074834 Affinity Capture-Western; Reconstituted Complex
TCF4MYOD11127878576241 Two-hybrid
TCF4MYOD11107378576241 Two-hybrid
TCF4TAL11127498576241 9242638 16407974 Affinity Capture-MS; Reconstituted Complex; Two-hybrid
TCF4TAL11127878576241 9242638 16407974 Affinity Capture-MS; Reconstituted Complex; Two-hybrid
TCF4TAL21127509242638 Two-hybrid
TCF4TAL21127879242638 Two-hybrid
MSCTCF41146699584154 Two-hybrid
MSCTCF41127879584154 Two-hybrid
HBP1TCF411278711500377 Affinity Capture-Western
HBP1TCF411792711500377 Affinity Capture-Western
RNF138TCF411278716714285 Affinity Capture-Western
RNF138TCF411954516714285 Affinity Capture-Western
UBCTCF411278716714285 Affinity Capture-Western
UBCTCF411316416714285 Affinity Capture-Western
PIAS4TCF411278720211142 Two-hybrid
PIAS4TCF411962420211142 Two-hybrid
ASCL3TCF411278720211142 Two-hybrid
ASCL3TCF412118420211142 Two-hybrid
TCF3TCF411278720211142 Two-hybrid
TCF3TCF411279120211142 Two-hybrid
GTF3C5TCF411473720211142 Two-hybrid
GTF3C5TCF411278720211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TCF4TCF4_CTG18.1, TCF4_CTGn, rs2958182, rs9960767 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:98506
  • Data Attributes: MGI curated and HomoloGene calculated
No data