AutismKB 2.0

Annotation Details for TBX3


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Basic Information Top
Gene Symbol:TBX3 ( TBX3-ISO,UMS,XHL )
Gene Full Name: T-box 3
Band: 12q24.21
Quick LinksEntrez ID:6926; OMIM: 601621; Uniprot ID:TBX3_HUMAN; ENSEMBL ID: ENSG00000135111; HGNC ID: 11602
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11689487
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding11689487
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding11689487
GO:0001085ISS-RNA polymerase II transcription factor binding-
GO:0001102ISS-RNA polymerase II activating transcription factor binding-
GO:0005515IPI-protein binding22002537
GO:0043565IDA-sequence-specific DNA binding11689487
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter11689487
GO:0001501IMP-skeletal system development9207801
GO:0001568IEA-blood vessel development-
GO:0001701IEA-in utero embryonic development-
GO:0001947IEA-heart looping-
GO:0003151IEA-outflow tract morphogenesis-
GO:0003167IEA-atrioventricular bundle cell differentiation-
GO:0006351IEA-transcription, DNA-templated-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter9207801
GO:0007569IDA-cell aging11689487
GO:0008284IDA-positive regulation of cell proliferation11689487
GO:0008595IMP-anterior/posterior axis specification, embryo9207801
GO:0009887IDA-animal organ morphogenesis9207801
GO:0010159IEA-specification of animal organ position-
GO:0019827IEA-stem cell population maintenance-
GO:0021761IEA-limbic system development-
GO:0030539IMP-male genitalia development12116211
GO:0030540IMP-female genitalia development12116211
GO:0030857IEA-negative regulation of epithelial cell differentiation-
GO:0030879IMP-mammary gland development12116211
GO:0032275IMP-luteinizing hormone secretion12116211
GO:0035115IMP-embryonic forelimb morphogenesis12116211
GO:0035116IEA-embryonic hindlimb morphogenesis-
GO:0035136IDA-forelimb morphogenesis9207801
GO:0042733IMP-embryonic digit morphogenesis9207801
GO:0043066IDA-negative regulation of apoptotic process12032820
GO:0045662IDA-negative regulation of myoblast differentiation12032820
GO:0045787IDA-positive regulation of cell cycle12032820
GO:0045892IDA-negative regulation of transcription, DNA-templated10468588
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0046884IMP-follicle-stimulating hormone secretion12116211
GO:0048332IMP-mesoderm morphogenesis9207801
GO:0060021IEA-palate development-
GO:0060412IEA-ventricular septum morphogenesis-
GO:0060444IEA-branching involved in mammary gland duct morphogenesis-
GO:0060596IEA-mammary placode formation-
GO:0060923IEA-cardiac muscle cell fate commitment-
GO:0060931IEA-sinoatrial node cell development-
GO:0090398IDA-cellular senescence22002537
GO:2000648IEA-positive regulation of stem cell proliferation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TBX3HDAC111278818245468 Affinity Capture-Western
TBX3HDAC110931518245468 Affinity Capture-Western
TBX3HDAC211278818245468 Affinity Capture-Western
TBX3HDAC210931618245468 Affinity Capture-Western
TBX3TBX311278812005433 Co-crystal Structure
HDAC5TBX311278818245468 Affinity Capture-Western
HDAC5TBX311533118245468 Affinity Capture-Western
HDAC3TBX311278818245468 Affinity Capture-Western
HDAC3TBX311436818245468 Affinity Capture-Western
TOLLIPTBX311278820936779 Two-hybrid
TOLLIPTBX311997820936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98495
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070209-80'