AutismKB 2.0

Annotation Details for TCF3


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Basic Information Top
Gene Symbol:TCF3 ( E2A,ITF1,MGC129647,MGC129648,VDIR,bHLHb21 )
Gene Full Name: transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
Band: 19p13.3
Quick LinksEntrez ID:6929; OMIM: 147141; Uniprot ID:TFE2_HUMAN; ENSEMBL ID: ENSG00000071564; HGNC ID: 11633
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin21828274
GO:0005634IDA-nucleus10775504
GO:0005634NAS-nucleus2493990
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IDA-transcription factor complex10775504
GO:0005737IDA-cytoplasm21828274
GO:0016607IDA-nuclear speck-
GO:0090575IDA-RNA polymerase II transcription factor complex10545951
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding14576336
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding14576336
GO:0003677IDA-DNA binding10958665
GO:0003677NAS-DNA binding2105528
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding2105528
GO:0003700NAS-transcription factor activity, sequence-specific DNA binding2493990
GO:0003713IDA-transcription coactivator activity14752053
GO:0005515IPI-protein binding7568177
GO:0008134IPI-transcription factor binding21828274
GO:0031435IPI-mitogen-activated protein kinase kinase kinase binding19801649
GO:0035326IC-enhancer binding21828274
GO:0042803IDA-protein homodimerization activity10958665
GO:0043425IPI-bHLH transcription factor binding10545951
GO:0046982IDA-protein heterodimerization activity10775504
GO:0046982IPI-protein heterodimerization activity10545951
GO:0046982NAS-protein heterodimerization activity2105528
GO:0070491IPI-repressing transcription factor binding12493738
GO:0070644IDA-vitamin D response element binding17426122
GO:0070888IDA-E-box binding7933101
GO:0070888IDAcontributes_toE-box binding10775504
GO:0070888ISScontributes_toE-box binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter14576336
GO:0002326NAS-B cell lineage commitment12435739
GO:0006351IDA-transcription, DNA-templated10775504
GO:0006355NAS-regulation of transcription, DNA-templated2493990
GO:0030183NAS-B cell differentiation12435739
GO:0033152IDA-immunoglobulin V(D)J recombination16428437
GO:0045666IBA-positive regulation of neuron differentiation-
GO:0045666ISS-positive regulation of neuron differentiation-
GO:0045893IDA-positive regulation of transcription, DNA-templated2105528
GO:0045893ISS-positive regulation of transcription, DNA-templated-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16428437
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity14752053
GO:0051149TAS-positive regulation of muscle cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TCF3CALM111279110757985 Reconstituted Complex
TCF3CALM110725210757985 Reconstituted Complex
TCF3RUNX111279115333839 Affinity Capture-Western
TCF3RUNX110730915333839 Affinity Capture-Western
TCF3RUNX1T111279115333839 Affinity Capture-Western
TCF3RUNX1T110731015333839 Affinity Capture-Western
TCF3CBFA2T311279116407974 Affinity Capture-Western; Reconstituted Complex
TCF3CBFA2T310731116407974 Affinity Capture-Western; Reconstituted Complex
TCF3CREBBP11279112435739 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
TCF3CREBBP10777712435739 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
TCF3DAXX11279119308989 Reconstituted Complex
TCF3DAXX10798519308989 Reconstituted Complex
TCF3ELK31127918918463 Affinity Capture-Western
TCF3ELK31083198918463 Affinity Capture-Western
TCF3EP30011279112435739 15934135 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Phenotypic Enhancement; Two-hybrid
TCF3EP30010834712435739 15934135 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Phenotypic Enhancement; Two-hybrid
TCF3HDAC211279115934135 16252006 Affinity Capture-Western
TCF3HDAC210931615934135 16252006 Affinity Capture-Western
TCF3ID11127919242638 19125693 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3ID11096239242638 19125693 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3ID21127919242638 Two-hybrid
TCF3ID21096249242638 Two-hybrid
TCF3ID31127919242638 9525934 Reconstituted Complex; Two-hybrid
TCF3ID31096259242638 9525934 Reconstituted Complex; Two-hybrid
TCF3LMX1A1127919199284 Reconstituted Complex; Two-hybrid
TCF3LMX1A1101949199284 Reconstituted Complex; Two-hybrid
TCF3LYL11127918628307 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3LYL11102448628307 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3MEN111038419074834 Affinity Capture-Western; Reconstituted Complex
TCF3MEN111279119074834 Affinity Capture-Western; Reconstituted Complex
TCF3MYF51127919242638 Two-hybrid
TCF3MYF51107029242638 Two-hybrid
TCF3MYF61127919242638 Two-hybrid
TCF3MYF61107039242638 Two-hybrid
TCF3MYOD11107379184158 9242638 Reconstituted Complex; Two-hybrid
TCF3MYOD11127919184158 9242638 Reconstituted Complex; Two-hybrid
TCF3MYOG1127911325437 9242638 Two-hybrid
TCF3MYOG1107391325437 9242638 Two-hybrid
TCF3NHLH111087212878195 Two-hybrid
TCF3NHLH111279112878195 Two-hybrid
TCF3PRKACA11155315934135 Biochemical Activity
TCF3PRKACA11279115934135 Biochemical Activity
TCF3SKP211239314592976 Affinity Capture-Western
TCF3SKP211279114592976 Affinity Capture-Western
TCF3SMARCA411279116252006 Affinity Capture-Western; Co-localization
TCF3SMARCA411248116252006 Affinity Capture-Western; Co-localization
TCF3TAL11127498159721 16407974 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3TAL11127918159721 16407974 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
TCF3TCF411278720211142 Two-hybrid
TCF3TCF411279120211142 Two-hybrid
UBE2ITCF311317710497239 Reconstituted Complex; Two-hybrid
UBE2ITCF311279110497239 Reconstituted Complex; Two-hybrid
TWIST1TCF311279110749989 Reconstituted Complex; Two-hybrid
TWIST1TCF311314210749989 Reconstituted Complex; Two-hybrid
MAPKAPK3TCF311361710781029 Affinity Capture-Western; Biochemical Activity; Two-hybrid
MAPKAPK3TCF311279110781029 Affinity Capture-Western; Biochemical Activity; Two-hybrid
HAND2TCF311485011812799 Two-hybrid
HAND2TCF311279111812799 Two-hybrid
KAT2BTCF311279112435739 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
KAT2BTCF311437512435739 Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
TCF3TCF311279112435739 Co-fractionation
SIN3ATCF311743915934135 16252006 Affinity Capture-Western
SIN3ATCF311279115934135 16252006 Affinity Capture-Western
NCOR1TCF311279115934135 16252006 Affinity Capture-Western
NCOR1TCF311497315934135 16252006 Affinity Capture-Western
VDRTCF311279115934135 16252006 Affinity Capture-Western; Co-localization; Reconstituted Complex
VDRTCF311326415934135 16252006 Affinity Capture-Western; Co-localization; Reconstituted Complex
BAZ1BTCF311449716252006 Affinity Capture-Western; Co-localization
BAZ1BTCF311279116252006 Affinity Capture-Western; Co-localization
LDB1TCF311279116407974 Affinity Capture-Western
LDB1TCF311438416407974 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:98510
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-51'