AutismKB 2.0

Annotation Details for TCF7L2


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Basic Information Top
Gene Symbol:TCF7L2 ( TCF-4,TCF4 )
Gene Full Name: transcription factor 7-like 2 (T-cell specific, HMG-box)
Band: 10q25.2-q25.3
Quick LinksEntrez ID:6934; OMIM: 602228; Uniprot ID:TF7L2_HUMAN; ENSEMBL ID: ENSG00000148737; HGNC ID: 11641
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000790IDA-nuclear chromatin19443654
GO:0005634IDA-nucleus9065401
GO:0005654IDA-nucleoplasm19168596
GO:0005654TAS-nucleoplasm-
GO:0016605IEA-PML body-
GO:0032993IDA-protein-DNA complex14661054
GO:0070369IDA-beta-catenin-TCF7L2 complex9065401
GO ID Evidence Qualifier GO_term References
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding19443654
GO:0001103IPI-RNA polymerase II repressing transcription factor binding19443654
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding9727977
GO:0005515IPI-protein binding11713475
GO:0008013IDA-beta-catenin binding9065401
GO:0008013IPI-beta-catenin binding12408825
GO:0008134IPI-transcription factor binding16007074
GO:0019901IPI-protein kinase binding16714285
GO:0035257IPI-nuclear hormone receptor binding12799378
GO:0043565IDA-sequence-specific DNA binding14661054
GO:0043565IMP-sequence-specific DNA binding16532032
GO:0044212IDA-transcription regulatory region DNA binding20128911
GO:0045295IPI-gamma-catenin binding14661054
GO:0070016IPI-armadillo repeat domain binding12408825
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter12799378
GO:0001568IMP-blood vessel development15578569
GO:0006351IEA-transcription, DNA-templated-
GO:0006357IDA-regulation of transcription from RNA polymerase II promoter9727977
GO:0007050IMP-cell cycle arrest12408868
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0008283IMP-cell proliferation12408868
GO:0009749ISS-response to glucose19168596
GO:0010909IMP-positive regulation of heparan sulfate proteoglycan biosynthetic process15853773
GO:0031016TAS-pancreas development18216022
GO:0032024IDA-positive regulation of insulin secretion-
GO:0032024IMP-positive regulation of insulin secretion19386626
GO:0032092IDA-positive regulation of protein binding12799378
GO:0032350IDA-regulation of hormone metabolic process15525634
GO:0042593IDA-glucose homeostasis15525634
GO:0043433IDA-negative regulation of sequence-specific DNA binding transcription factor activity12799378
GO:0043570IMP-maintenance of DNA repeat elements18755497
GO:0044334IMP-canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition17072303
GO:0045444IDA-fat cell differentiation10937998
GO:0045892IDA-negative regulation of transcription, DNA-templated12799378
GO:0045892IMP-negative regulation of transcription, DNA-templated16532032
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter9065401
GO:0046827IMP-positive regulation of protein export from nucleus19386626
GO:0048625IDA-myoblast fate commitment10937998
GO:0048660IMP-regulation of smooth muscle cell proliferation17122440
GO:0051897IMP-positive regulation of protein kinase B signaling19386626
GO:0060070IC-canonical Wnt signaling pathway9065401
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway16532032
GO:1904837TAS-beta-catenin-TCF complex assembly-
GO:2000675IDA-negative regulation of type B pancreatic cell apoptotic process-
GO:2001237IDA-negative regulation of extrinsic apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TCF7L2CEBPA11279512861022 Phenotypic Enhancement
TCF7L2CEBPA10747912861022 Phenotypic Enhancement
TCF7L2CTBP111279512711682 Reconstituted Complex
TCF7L2CTBP110786912711682 Reconstituted Complex
TCF7L2CTNNB111279512861022 19304756 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression
TCF7L2CTNNB110788012861022 19304756 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression
TCF7L2EP30010834712861022 Phenotypic Enhancement
TCF7L2EP30011279512861022 Phenotypic Enhancement
TCF7L2NR5A111279512861022 Phenotypic Enhancement
TCF7L2NR5A110879212861022 Phenotypic Enhancement
TCF7L2JUP11279511711551 Reconstituted Complex
TCF7L2JUP10993111711551 Reconstituted Complex
TCF7L2PSEN111279511504726 Affinity Capture-Western
TCF7L2PSEN111164211504726 Affinity Capture-Western
NLKTCF7L211968512556497 Affinity Capture-Western
NLKTCF7L211279512556497 Affinity Capture-Western
DAZAP2TCF7L211279519304756 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DAZAP2TCF7L211514319304756 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
Gene Symbol Interactant Interaction ID References Description
TCF7L2RAC120938115377999 Rac1 interacts with TCF4.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
TCF7L2rs7901695 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1202879
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-991110-8'