AutismKB 2.0

Annotation Details for ZEB1


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Basic Information Top
Gene Symbol:ZEB1 ( AREB6,BZP,DELTAEF1,FECD6,MGC133261,NIL2A,TCF8,ZFHEP,ZFHX1A )
Gene Full Name: zinc finger E-box binding homeobox 1
Band: 10p11.22
Quick LinksEntrez ID:6935; OMIM: 189909; Uniprot ID:ZEB1_HUMAN; ENSEMBL ID: ENSG00000148516; HGNC ID: 11642
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20418909
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005667IEA-transcription factor complex-
GO:0005829IDA-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0001227IDA-transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding23765923
GO:0003682IEA-chromatin binding-
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding8138542
GO:0003713TAS-transcription coactivator activity8138542
GO:0003714TAS-transcription corepressor activity8138542
GO:0005515IPI-protein binding20418909
GO:0008134IEA-transcription factor binding-
GO:0008270TAS-zinc ion binding8138542
GO:0070888ISS-E-box binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter23765923
GO:0006351IEA-transcription, DNA-templated-
GO:0006357TAS-regulation of transcription from RNA polymerase II promoter8138542
GO:0006955TAS-immune response1840704
GO:0007389IEA-pattern specification process-
GO:0007417IEA-central nervous system development-
GO:0008283TAS-cell proliferation1840704
GO:0008285IEA-negative regulation of cell proliferation-
GO:0010464IEA-regulation of mesenchymal cell proliferation-
GO:0017015IEA-regulation of transforming growth factor beta receptor signaling pathway-
GO:0033081IEA-regulation of T cell differentiation in thymus-
GO:0045602IMP-negative regulation of endothelial cell differentiation23765923
GO:0045666ISS-positive regulation of neuron differentiation-
GO:0045892IDA-negative regulation of transcription, DNA-templated20418909
GO:0045892IMP-negative regulation of transcription, DNA-templated12937339
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048596IEA-embryonic camera-type eye morphogenesis-
GO:0048704IEA-embryonic skeletal system morphogenesis-
GO:0048752IEA-semicircular canal morphogenesis-
GO:0051150IEA-regulation of smooth muscle cell differentiation-
GO:0051216IEA-cartilage development-
GO:0071230IEA-cellular response to amino acid stimulus-
GO:0090103IEA-cochlea morphogenesis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ZEB1CTBP111279610359772 17967884 Affinity Capture-Western
ZEB1CTBP110786910359772 17967884 Affinity Capture-Western
ZEB1CTBP210787010359772 19754958 Affinity Capture-Western
ZEB1CTBP211279610359772 19754958 Affinity Capture-Western
ZEB1SMAD111026112743038 Affinity Capture-Western
ZEB1SMAD111279612743038 Affinity Capture-Western
ZEB1SMAD211026212743038 Affinity Capture-Western
ZEB1SMAD211279612743038 Affinity Capture-Western
ZEB1SMAD311026312743038 Affinity Capture-Western
ZEB1SMAD311279612743038 Affinity Capture-Western
DRAP1ZEB11127969418848 Two-hybrid
DRAP1ZEB11158389418848 Two-hybrid
KAT5ZEB111279611275565 Two-hybrid
KAT5ZEB111577911275565 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1344313
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010621-1'