Gene Symbol:	TERT ( EST2,TCS1,TP2,TRT,hEST2 )
Gene Full Name:	telomerase reverse transcriptase
Band:	5p15.33
Quick Links	Entrez ID:7015; OMIM: 187270; Uniprot ID:TERT_HUMAN; ENSEMBL ID: ENSG00000164362; HGNC ID: 11730
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000333	IDA	-	telomerase catalytic core complex	9398860
GO:0000333	IMP	-	telomerase catalytic core complex	11313459
GO:0000333	IPI	-	telomerase catalytic core complex	19701182
GO:0000781	IC	-	chromosome, telomeric region	12135483
GO:0000783	IC	-	nuclear telomere cap complex	15632080
GO:0000784	IDA	-	nuclear chromosome, telomeric region	25589350
GO:0005634	IDA	-	nucleus	21829167
GO:0005654	IDA	-	nucleoplasm	19567472
GO:0005654	TAS	-	nucleoplasm	-
GO:0005697	IDA	-	telomerase holoenzyme complex	12135483
GO:0005697	IPI	-	telomerase holoenzyme complex	19701182
GO:0005697	TAS	-	telomerase holoenzyme complex	10757788
GO:0005730	IDA	-	nucleolus	22226966
GO:0005730	NAS	-	nucleolus	26194824
GO:0005886	IEA	-	plasma membrane	-
GO:0016605	IDA	colocalizes_with	PML body	19567472
GO:0031379	IPI	-	RNA-directed RNA polymerase complex	19701182
GO:0042645	IDA	-	mitochondrial nucleoid	21937513
GO:1990572	IDA	-	TERT-RMRP complex	19701182

GO ID	Evidence	Qualifier	GO_term	References
GO:0000049	IDA	-	tRNA binding	21937513
GO:0001223	IPI	-	transcription coactivator binding	19571879
GO:0003677	IDA	-	DNA binding	21937513
GO:0003720	IDA	-	telomerase activity	12135483
GO:0003720	IDA	contributes_to	telomerase activity	9398860
GO:0003720	TAS	-	telomerase activity	11927518
GO:0003720	TAS	contributes_to	telomerase activity	23474713
GO:0003721	IDA	-	telomerase RNA reverse transcriptase activity	9398860
GO:0003721	IDA	contributes_to	telomerase RNA reverse transcriptase activity	19701182
GO:0003721	IMP	contributes_to	telomerase RNA reverse transcriptase activity	11313459
GO:0003721	TAS	-	telomerase RNA reverse transcriptase activity	14991929
GO:0003723	IPI	-	RNA binding	19701182
GO:0003964	IDA	-	RNA-directed DNA polymerase activity	21937513
GO:0003964	TAS	-	RNA-directed DNA polymerase activity	25569094
GO:0003968	IDA	contributes_to	RNA-directed 5'-3' RNA polymerase activity	19701182
GO:0005515	IPI	-	protein binding	11701125
GO:0016779	IDA	-	nucleotidyltransferase activity	19701182
GO:0016779	IDA	contributes_to	nucleotidyltransferase activity	19701182
GO:0042162	TAS	-	telomeric DNA binding	9288757
GO:0042803	IDA	-	protein homodimerization activity	11432839
GO:0042803	IPI	-	protein homodimerization activity	23474713
GO:0046872	IEA	-	metal ion binding	-
GO:0051087	IPI	-	chaperone binding	10197982
GO:0070034	IDA	-	telomerase RNA binding	11432839
GO:0070034	IPI	-	telomerase RNA binding	16507993
GO:0098680	IDA	contributes_to	template-free RNA nucleotidyltransferase	19701182

GO ID	Evidence	Qualifier	GO_term	References
GO:0000723	TAS	-	telomere maintenance	12135483
GO:0001172	IDA	-	transcription, RNA-templated	19701182
GO:0006278	IDA	-	RNA-dependent DNA biosynthetic process	9398860
GO:0007004	IDA	-	telomere maintenance via telomerase	9443919
GO:0007004	IMP	-	telomere maintenance via telomerase	9454332
GO:0007004	NAS	-	telomere maintenance via telomerase	2805070
GO:0007004	TAS	-	telomere maintenance via telomerase	-
GO:0007005	IDA	-	mitochondrion organization	21937513
GO:0010629	IDA	-	negative regulation of gene expression	11927518
GO:0022616	IDA	-	DNA strand elongation	16043710
GO:0030177	IGI	-	positive regulation of Wnt signaling pathway	19571879
GO:0030422	IDA	-	production of siRNA involved in RNA interference	19701182
GO:0031647	IDA	-	regulation of protein stability	24415760
GO:0031647	IMP	-	regulation of protein stability	26194824
GO:0032092	IDA	-	positive regulation of protein binding	24415760
GO:0032774	IDA	-	RNA biosynthetic process	19701182
GO:0042635	ISS	-	positive regulation of hair cycle	-
GO:0043524	IEA	-	negative regulation of neuron apoptotic process	-
GO:0045766	IEA	-	positive regulation of angiogenesis	-
GO:0046326	IEA	-	positive regulation of glucose import	-
GO:0046686	IEA	-	response to cadmium ion	-
GO:0051000	IDA	-	positive regulation of nitric-oxide synthase activity	11927518
GO:0060253	IEA	-	negative regulation of glial cell proliferation	-
GO:0070200	IDA	-	establishment of protein localization to telomere	25589350
GO:0071456	IMP	-	cellular response to hypoxia	11313459
GO:0071897	IDA	-	DNA biosynthetic process	9398860
GO:0090399	IMP	-	replicative senescence	9454332
GO:1900087	IEA	-	positive regulation of G1/S transition of mitotic cell cycle	-
GO:1902895	IMP	-	positive regulation of pri-miRNA transcription from RNA polymerase II promoter	25569094
GO:1903620	IEA	-	positive regulation of transdifferentiation	-
GO:1903704	IDA	-	negative regulation of production of siRNA involved in RNA interference	19701182
GO:1904707	IEA	-	positive regulation of vascular smooth muscle cell proliferation	-
GO:1904751	IDA	-	positive regulation of protein localization to nucleolus	24415760
GO:1904754	IEA	-	positive regulation of vascular associated smooth muscle cell migration	-
GO:1904837	TAS	-	beta-catenin-TCF complex assembly	-
GO:2000352	IEA	-	negative regulation of endothelial cell apoptotic process	-
GO:2000648	ISS	-	positive regulation of stem cell proliferation	-
GO:2000773	IDA	-	negative regulation of cellular senescence	11927518
GO:2000773	IMP	-	negative regulation of cellular senescence	11313459
GO:2001240	IMP	-	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	10449030

Gene Symbol	Interactant	Interaction ID	References	Description
TERT	AKT1	112874	15843522	Affinity Capture-Western
TERT	AKT1	106710	15843522	Affinity Capture-Western
TERT	MTOR	108757	15843522	Affinity Capture-Western
TERT	MTOR	112874	15843522	Affinity Capture-Western
TERT	XRCC6	112874	12377759	Affinity Capture-Western; Reconstituted Complex
TERT	XRCC6	108822	12377759	Affinity Capture-Western; Reconstituted Complex
TERT	HSP90AA1	112874	12586360 15843522	Affinity Capture-Western
TERT	HSP90AA1	109552	12586360 15843522	Affinity Capture-Western
TERT	NCL	112874	15371412	Affinity Capture-Western; Reconstituted Complex
TERT	NCL	110771	15371412	Affinity Capture-Western; Reconstituted Complex
TERT	PML	111384	19567472	Affinity Capture-Western
TERT	PML	112874	19567472	Affinity Capture-Western
TERT	RELA	112874	12517770	Affinity Capture-Western
TERT	RELA	111902	12517770	Affinity Capture-Western
TERT	RPS6KB1	112112	15843522	Affinity Capture-Western
TERT	RPS6KB1	112874	15843522	Affinity Capture-Western
TERT	TEP1	112874	11029039	Affinity Capture-Western
TERT	TEP1	112870	11029039	Affinity Capture-Western
YWHAQ	TERT	116168	10835362	Reconstituted Complex; Two-hybrid
YWHAQ	TERT	112874	10835362	Reconstituted Complex; Two-hybrid
YWHAZ	TERT	113366	10835362	Two-hybrid
YWHAZ	TERT	112874	10835362	Two-hybrid
PTGES3	TERT	115952	11274138	Affinity Capture-Western
PTGES3	TERT	112874	11274138	Affinity Capture-Western
PINX1	TERT	112874	11701125	Affinity Capture-Western; Reconstituted Complex
PINX1	TERT	120319	11701125	Affinity Capture-Western; Reconstituted Complex
XRCC5	TERT	113353	12377759	Affinity Capture-Western; Reconstituted Complex
XRCC5	TERT	112874	12377759	Affinity Capture-Western; Reconstituted Complex
SMG6	TERT	116888	12699629	Reconstituted Complex
SMG6	TERT	112874	12699629	Reconstituted Complex
SMG5	TERT	116957	12699629	Reconstituted Complex
SMG5	TERT	112874	12699629	Reconstituted Complex
MCRS1	TERT	115710	15044100	Affinity Capture-Western; Reconstituted Complex
MCRS1	TERT	112874	15044100	Affinity Capture-Western; Reconstituted Complex
MKRN1	TERT	117141	15805468	Affinity Capture-Western
MKRN1	TERT	112874	15805468	Affinity Capture-Western
UBC	TERT	113164	15805468	Affinity Capture-Western
UBC	TERT	112874	15805468	Affinity Capture-Western
NAT10	TERT	112874	18082603	Affinity Capture-Western
NAT10	TERT	120521	18082603	Affinity Capture-Western
MUS81	TERT	112874	19363487	Synthetic Rescue
MUS81	TERT	123170	19363487	Synthetic Rescue

AutismKB 2.0

Annotation Details for TERT