AutismKB 2.0

Annotation Details for TERT


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Basic Information Top
Gene Symbol:TERT ( EST2,TCS1,TP2,TRT,hEST2 )
Gene Full Name: telomerase reverse transcriptase
Band: 5p15.33
Quick LinksEntrez ID:7015; OMIM: 187270; Uniprot ID:TERT_HUMAN; ENSEMBL ID: ENSG00000164362; HGNC ID: 11730
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000333IDA-telomerase catalytic core complex9398860
GO:0000333IMP-telomerase catalytic core complex11313459
GO:0000333IPI-telomerase catalytic core complex19701182
GO:0000781IC-chromosome, telomeric region12135483
GO:0000783IC-nuclear telomere cap complex15632080
GO:0000784IDA-nuclear chromosome, telomeric region25589350
GO:0005634IDA-nucleus21829167
GO:0005654IDA-nucleoplasm19567472
GO:0005654TAS-nucleoplasm-
GO:0005697IDA-telomerase holoenzyme complex12135483
GO:0005697IPI-telomerase holoenzyme complex19701182
GO:0005697TAS-telomerase holoenzyme complex10757788
GO:0005730IDA-nucleolus22226966
GO:0005730NAS-nucleolus26194824
GO:0005886IEA-plasma membrane-
GO:0016605IDAcolocalizes_withPML body19567472
GO:0031379IPI-RNA-directed RNA polymerase complex19701182
GO:0042645IDA-mitochondrial nucleoid21937513
GO:1990572IDA-TERT-RMRP complex19701182
GO ID Evidence Qualifier GO_term References
GO:0000049IDA-tRNA binding21937513
GO:0001223IPI-transcription coactivator binding19571879
GO:0003677IDA-DNA binding21937513
GO:0003720IDA-telomerase activity12135483
GO:0003720IDAcontributes_totelomerase activity9398860
GO:0003720TAS-telomerase activity11927518
GO:0003720TAScontributes_totelomerase activity23474713
GO:0003721IDA-telomerase RNA reverse transcriptase activity9398860
GO:0003721IDAcontributes_totelomerase RNA reverse transcriptase activity19701182
GO:0003721IMPcontributes_totelomerase RNA reverse transcriptase activity11313459
GO:0003721TAS-telomerase RNA reverse transcriptase activity14991929
GO:0003723IPI-RNA binding19701182
GO:0003964IDA-RNA-directed DNA polymerase activity21937513
GO:0003964TAS-RNA-directed DNA polymerase activity25569094
GO:0003968IDAcontributes_toRNA-directed 5'-3' RNA polymerase activity19701182
GO:0005515IPI-protein binding11701125
GO:0016779IDA-nucleotidyltransferase activity19701182
GO:0016779IDAcontributes_tonucleotidyltransferase activity19701182
GO:0042162TAS-telomeric DNA binding9288757
GO:0042803IDA-protein homodimerization activity11432839
GO:0042803IPI-protein homodimerization activity23474713
GO:0046872IEA-metal ion binding-
GO:0051087IPI-chaperone binding10197982
GO:0070034IDA-telomerase RNA binding11432839
GO:0070034IPI-telomerase RNA binding16507993
GO:0098680IDAcontributes_totemplate-free RNA nucleotidyltransferase19701182
GO ID Evidence Qualifier GO_term References
GO:0000723TAS-telomere maintenance12135483
GO:0001172IDA-transcription, RNA-templated19701182
GO:0006278IDA-RNA-dependent DNA biosynthetic process9398860
GO:0007004IDA-telomere maintenance via telomerase9443919
GO:0007004IMP-telomere maintenance via telomerase9454332
GO:0007004NAS-telomere maintenance via telomerase2805070
GO:0007004TAS-telomere maintenance via telomerase-
GO:0007005IDA-mitochondrion organization21937513
GO:0010629IDA-negative regulation of gene expression11927518
GO:0022616IDA-DNA strand elongation16043710
GO:0030177IGI-positive regulation of Wnt signaling pathway19571879
GO:0030422IDA-production of siRNA involved in RNA interference19701182
GO:0031647IDA-regulation of protein stability24415760
GO:0031647IMP-regulation of protein stability26194824
GO:0032092IDA-positive regulation of protein binding24415760
GO:0032774IDA-RNA biosynthetic process19701182
GO:0042635ISS-positive regulation of hair cycle-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0045766IEA-positive regulation of angiogenesis-
GO:0046326IEA-positive regulation of glucose import-
GO:0046686IEA-response to cadmium ion-
GO:0051000IDA-positive regulation of nitric-oxide synthase activity11927518
GO:0060253IEA-negative regulation of glial cell proliferation-
GO:0070200IDA-establishment of protein localization to telomere25589350
GO:0071456IMP-cellular response to hypoxia11313459
GO:0071897IDA-DNA biosynthetic process9398860
GO:0090399IMP-replicative senescence9454332
GO:1900087IEA-positive regulation of G1/S transition of mitotic cell cycle-
GO:1902895IMP-positive regulation of pri-miRNA transcription from RNA polymerase II promoter25569094
GO:1903620IEA-positive regulation of transdifferentiation-
GO:1903704IDA-negative regulation of production of siRNA involved in RNA interference19701182
GO:1904707IEA-positive regulation of vascular smooth muscle cell proliferation-
GO:1904751IDA-positive regulation of protein localization to nucleolus24415760
GO:1904754IEA-positive regulation of vascular associated smooth muscle cell migration-
GO:1904837TAS-beta-catenin-TCF complex assembly-
GO:2000352IEA-negative regulation of endothelial cell apoptotic process-
GO:2000648ISS-positive regulation of stem cell proliferation-
GO:2000773IDA-negative regulation of cellular senescence11927518
GO:2000773IMP-negative regulation of cellular senescence11313459
GO:2001240IMP-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10449030
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TERTAKT111287415843522 Affinity Capture-Western
TERTAKT110671015843522 Affinity Capture-Western
TERTMTOR10875715843522 Affinity Capture-Western
TERTMTOR11287415843522 Affinity Capture-Western
TERTXRCC611287412377759 Affinity Capture-Western; Reconstituted Complex
TERTXRCC610882212377759 Affinity Capture-Western; Reconstituted Complex
TERTHSP90AA111287412586360 15843522 Affinity Capture-Western
TERTHSP90AA110955212586360 15843522 Affinity Capture-Western
TERTNCL11287415371412 Affinity Capture-Western; Reconstituted Complex
TERTNCL11077115371412 Affinity Capture-Western; Reconstituted Complex
TERTPML11138419567472 Affinity Capture-Western
TERTPML11287419567472 Affinity Capture-Western
TERTRELA11287412517770 Affinity Capture-Western
TERTRELA11190212517770 Affinity Capture-Western
TERTRPS6KB111211215843522 Affinity Capture-Western
TERTRPS6KB111287415843522 Affinity Capture-Western
TERTTEP111287411029039 Affinity Capture-Western
TERTTEP111287011029039 Affinity Capture-Western
YWHAQTERT11616810835362 Reconstituted Complex; Two-hybrid
YWHAQTERT11287410835362 Reconstituted Complex; Two-hybrid
YWHAZTERT11336610835362 Two-hybrid
YWHAZTERT11287410835362 Two-hybrid
PTGES3TERT11595211274138 Affinity Capture-Western
PTGES3TERT11287411274138 Affinity Capture-Western
PINX1TERT11287411701125 Affinity Capture-Western; Reconstituted Complex
PINX1TERT12031911701125 Affinity Capture-Western; Reconstituted Complex
XRCC5TERT11335312377759 Affinity Capture-Western; Reconstituted Complex
XRCC5TERT11287412377759 Affinity Capture-Western; Reconstituted Complex
SMG6TERT11688812699629 Reconstituted Complex
SMG6TERT11287412699629 Reconstituted Complex
SMG5TERT11695712699629 Reconstituted Complex
SMG5TERT11287412699629 Reconstituted Complex
MCRS1TERT11571015044100 Affinity Capture-Western; Reconstituted Complex
MCRS1TERT11287415044100 Affinity Capture-Western; Reconstituted Complex
MKRN1TERT11714115805468 Affinity Capture-Western
MKRN1TERT11287415805468 Affinity Capture-Western
UBCTERT11316415805468 Affinity Capture-Western
UBCTERT11287415805468 Affinity Capture-Western
NAT10TERT11287418082603 Affinity Capture-Western
NAT10TERT12052118082603 Affinity Capture-Western
MUS81TERT11287419363487 Synthetic Rescue
MUS81TERT12317019363487 Synthetic Rescue
Gene Symbol Interactant Interaction ID References Description
TERTNCL18045515371412 nucleolin interacts with hTERT.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1202709
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080405-1'