AutismKB 2.0

Annotation Details for TFAP2B


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Basic Information Top
Gene Symbol:TFAP2B ( AP-2B,AP2-B,MGC21381 )
Gene Full Name: transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Band: 6p12.3
Quick LinksEntrez ID:7021; OMIM: 601601; Uniprot ID:AP2B_HUMAN; ENSEMBL ID: ENSG00000008196; HGNC ID: 11743
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IC-nucleus12169688
GO:0005634IDA-nucleus20607706
GO:0005654TAS-nucleoplasm-
GO ID Evidence Qualifier GO_term References
GO:0000979IDA-RNA polymerase II core promoter sequence-specific DNA binding7555706
GO:0000981IDA-RNA polymerase II transcription factor activity, sequence-specific DNA binding7555706
GO:0000983ISS-transcription factor activity, RNA polymerase II core promoter sequence-specific-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001105ISS-RNA polymerase II transcription coactivator activity-
GO:0001106ISS-RNA polymerase II transcription corepressor activity-
GO:0001158IDA-enhancer sequence-specific DNA binding16373396
GO:0003677TAS-DNA binding12072434
GO:0003682IEA-chromatin binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding11505339
GO:0003713IDA-transcription coactivator activity7555706
GO:0003714IDA-transcription corepressor activity7559606
GO:0005515IPI-protein binding7555706
GO:0042803IPI-protein homodimerization activity11505339
GO:0043027ISS-cysteine-type endopeptidase inhibitor activity involved in apoptotic process-
GO:0043565IDA-sequence-specific DNA binding11505339
GO:0046982IPI-protein heterodimerization activity11505339
GO:0046983IDA-protein dimerization activity12072434
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter7559606
GO:0000122TAS-negative regulation of transcription from RNA polymerase II promoter-
GO:0001822ISS-kidney development-
GO:0003091ISS-renal water homeostasis-
GO:0006006IMP-glucose metabolic process15940393
GO:0006355IDA-regulation of transcription, DNA-templated12169688
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006915IEA-apoptotic process-
GO:0008284IDA-positive regulation of cell proliferation17525748
GO:0008285IDA-negative regulation of cell proliferation20607706
GO:0010226IEA-response to lithium ion-
GO:0010842IEP-retina layer formation20607706
GO:0010960ISS-magnesium ion homeostasis-
GO:0030510ISS-regulation of BMP signaling pathway-
GO:0035136ISS-forelimb morphogenesis-
GO:0035137ISS-hindlimb morphogenesis-
GO:0035810ISS-positive regulation of urine volume-
GO:0035909ISS-aorta morphogenesis-
GO:0042493IEA-response to drug-
GO:0042593ISS-glucose homeostasis-
GO:0043066IDA-negative regulation of apoptotic process17525748
GO:0043066ISS-negative regulation of apoptotic process-
GO:0043154ISS-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043524IEA-negative regulation of neuron apoptotic process-
GO:0043525IDA-positive regulation of neuron apoptotic process20607706
GO:0043588IEA-skin development-
GO:0045444IEP-fat cell differentiation16373396
GO:0045595IDA-regulation of cell differentiation20607706
GO:0045892IDA-negative regulation of transcription, DNA-templated20607706
GO:0045893IDA-positive regulation of transcription, DNA-templated11505339
GO:0045893IMP-positive regulation of transcription, DNA-templated16373396
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter7555706
GO:0045944TAS-positive regulation of transcription from RNA polymerase II promoter-
GO:0048485ISS-sympathetic nervous system development-
GO:0050796IMP-regulation of insulin secretion15940393
GO:0055062ISS-phosphate ion homeostasis-
GO:0055074ISS-calcium ion homeostasis-
GO:0055075ISS-potassium ion homeostasis-
GO:0055078ISS-sodium ion homeostasis-
GO:0072017ISS-distal tubule development-
GO:0072044ISS-collecting duct development-
GO:0072210IEA-metanephric nephron development-
GO:0097070ISS-ductus arteriosus closure-
GO:0097275ISS-cellular ammonia homeostasis-
GO:0097276ISS-cellular creatinine homeostasis-
GO:0097277ISS-cellular urea homeostasis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
TFAP2BGRB210914212577067 Affinity Capture-MS
TFAP2BGRB211287912577067 Affinity Capture-MS
TFAP2BCITED111057211744733 Reconstituted Complex
TFAP2BCITED111287911744733 Reconstituted Complex
CITED2TFAP2B11564911744733 Reconstituted Complex
CITED2TFAP2B11287911744733 Reconstituted Complex
CITED4TFAP2B11287911744733 Reconstituted Complex
CITED4TFAP2B12787511744733 Reconstituted Complex
SSBP4TFAP2B12800620211142 Two-hybrid
SSBP4TFAP2B11287920211142 Two-hybrid
LZTR1TFAP2B11385220211142 Two-hybrid
LZTR1TFAP2B11287920211142 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
TFAP2BTFAP2B_[CAAA]n, rs1569777, rs2076309, rs760900, rs875712 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104672
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050417-394'