AutismKB 2.0

Annotation Details for TFAP4


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Basic Information Top
Gene Symbol:TFAP4 ( AP-4,bHLHc41 )
Gene Full Name: transcription factor AP-4 (activating enhancer binding protein 4)
Band: 16p13.3
Quick LinksEntrez ID:7023; OMIM: 600743; Uniprot ID:TFAP4_HUMAN; ENSEMBL ID: ENSG00000090447; HGNC ID: 11745
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus7933101
GO:0005739IDA-mitochondrion-
GO:0017053ISS-transcriptional repressor complex-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677IDA-DNA binding9931457
GO:0003705IDA-transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding2833704
GO:0003713IDANOTtranscription coactivator activity11171123
GO:0005515IPI-protein binding19505873
GO:0042803IPI-protein homodimerization activity2123466
GO:0042826IPI-histone deacetylase binding16540471
GO:0043565IDA-sequence-specific DNA binding2123466
GO:0044212IDA-transcription regulatory region DNA binding14645924
GO:0046982IMPNOTprotein heterodimerization activity2123466
GO:0070888IDA-E-box binding7933101
GO ID Evidence Qualifier GO_term References
GO:0006366IEA-transcription from RNA polymerase II promoter-
GO:0006461IDA-protein complex assembly19505873
GO:0006978IDA-DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator18818310
GO:0008285IMP-negative regulation of cell proliferation18818310
GO:0043065IDA-positive regulation of apoptotic process18818310
GO:0043392IDA-negative regulation of DNA binding7933101
GO:0043922IDA-negative regulation by host of viral transcription14645924
GO:0043922NAS-negative regulation by host of viral transcription7933101
GO:0043923IDA-positive regulation by host of viral transcription2833704
GO:0045736IDA-negative regulation of cyclin-dependent protein serine/threonine kinase activity18818310
GO:0045892IDA-negative regulation of transcription, DNA-templated9931457
GO:0045892IMP-negative regulation of transcription, DNA-templated18818310
GO:0045893IMP-positive regulation of transcription, DNA-templated12663744
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0071157IMP-negative regulation of cell cycle arrest18818310
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:1901990IDA-regulation of mitotic cell cycle phase transition18818310
GO:2001269IEA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FBXW11TFAP411688719615732 Affinity Capture-MS
FBXW11TFAP411288119615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103239
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-090810-1'